分类归档 zudao

On November 29th, 2004, Caiqi [2004] No.252.

All provinces, autonomous regions, municipalities directly under the central government, the financial departments (bureaus), the competent commercial departments, the Finance Bureau and the Commerce Bureau of Xinjiang Production and Construction Corps, all foreign business institutions, and all centrally managed enterprises:
　　In order to support and encourage enterprises with comparative advantages to "go global" and expand their foreign contracted projects, according to the budget arrangement of the central government’s foreign aid joint venture project fund in 2004, the commercial loans obtained by Chinese enterprises from domestic banks for the implementation of foreign contracted projects will be subsidized. The relevant matters are hereby notified as follows:
　　I. Conditions for enterprises and projects applying for discount interest.
　　(1) An enterprise applying for discount must meet the following conditions:
　　1 registered in accordance with the law, and has an independent legal personality;
　　2. Qualification for foreign economic cooperation approved by the state;
　　3. There is no malicious default or misappropriation of foreign aid joint venture and cooperation project funds;
　　4. Accept the coordination of financial and commercial departments and our foreign economic and commercial institutions.
　　(two) to apply for discount projects must meet the following conditions:
　　1. Submit the statistical data of the project in accordance with the provisions of the Statistical System of Foreign Economic Cooperation Business;
　　2. The project contract is valid from January 1, 2004 to December 31, 2004, and the contract amount of a single project is not less than 10 million US dollars (or other equivalent currencies);
　　3. The loan contract of the project is valid from January 1, 2004 to December 31, 2004, and the single loan amount is not less than 10 million yuan (or equivalent foreign currency);
　　4. The contracted enterprise and the loan enterprise must be the same enterprise;
　　5. In line with China’s foreign trade and economic policies.
　　Second, the application materials and procedures
　　(1) When applying for discount, an enterprise shall provide the following materials:
　　1. Discount application report;
　　2 "Enterprise Declaration Notes" (Annex 1);
　　3. Basic Information of Foreign Contracted Projects and List of Interest Payment of Bank Loans in 2004 (Annex 2);
　　4. Copy of the business license of the enterprise as a legal person;
　　5. A copy of the commercial part of the project contract (Chinese version or Chinese translation);
　　6. Written opinions of overseas economic and commercial institutions on the implementation of the project, including: contract amount, commencement date, image progress, estimated completion date, etc.;
　　7. A copy of the bank loan contract;
　　8. A copy of the settlement voucher for bank loans, interest payment and loan repayment.
　　(2) application procedures:
　　1. Local enterprises will submit the above materials to the local provincial finance and commerce authorities before February 28, 2005, and the provincial finance and commerce authorities will conduct a preliminary examination of the projects applying for interest discount according to the provisions of this notice, fill in the Summary of Preliminary Examination of Loan Interest Discount for Foreign Contracted Projects (Annex 4), and jointly report to the Ministry of Finance and the Ministry of Commerce before March 31, 2005;
　　2. Enterprises managed by the central government will submit the Summary of Preliminary Examination of Loan Discount for Foreign Contracted Projects (Annex 4) together with relevant application materials to the Ministry of Finance and the Ministry of Commerce respectively before March 31, 2005;
　　3. The Ministry of Finance and the Ministry of Commerce entrust intermediaries to jointly issue discount funds after reviewing the declared projects;
　　4. Within 15 days after the two ministries issued the notice of financial discount funds for foreign contracted project loans of relevant enterprises this year, the Ministry of Commerce will directly allocate the discount funds to the enterprises.
　　Third, the discount standard
　　(a) the annual discount rate is not higher than 2 percentage points;
　　(2) The discount period is calculated according to the calendar month of the actual loan period;
　　(3) The project enjoys discount interest for a maximum of 3 years;
　　(four) interest rate hikes, penalty interest, etc. other than normal loans are not subsidized;
　　(five) each foreign contracted project can only enjoy a loan discount;
　　(6) The discount amount shall be calculated in RMB.
　　Four, foreign business institutions shall issue written opinions for enterprises in accordance with the requirements of item 6 of the first paragraph of Article 2 of this notice (Annex 3).
　　Five, in order to do a good job in financial discount in 2004, improve efficiency, please enterprises in accordance with the provisions of this notice, carefully prepare the discount application materials and bind them in order, according to the project directory.
　　Six, after receiving the discount interest funds, the enterprise will make a reduction of the financial expenses of the current year. No unit may cheat or intercept discount interest funds in any form or for any reason. In violation of the provisions, the Ministry of Finance and the Ministry of Commerce will fully recover the discount funds and cancel their discount eligibility. At the same time, investigate the responsibility of the relevant personnel.
　　Seven, the financial and commercial departments will supervise and inspect the implementation of discount interest funds, to ensure that discount interest funds in place in time, earmarking.
　　Attachment: 1. Description of enterprise declaration
　　　　　2. Basic information of foreign contracted projects and interest payment list of bank loans in 2004.
　　　　　3 in _ _ _ _ _ Economic and Commercial Counsellor’s Office (room) opinion
　　　　　4. Summary table of preliminary examination of loan discount for foreign contracted projects

　　People’s Daily Online, Beijing, January 30 (Reporter Lu Jing) On January 30, the joint prevention and control mechanism of the State Council held a press conference. Han Jinghua, Deputy Director of the Transport Services Department of the Ministry of Transport, attended the conference and answered questions from reporters.

　　This year, the passenger flow in Spring Festival travel rush has increased substantially. How can the Ministry of Transport do a good job in epidemic prevention and control and service? Han Jinghua introduced that there are four specific measures as follows:

　　The first is to formulate and implement epidemic prevention guidelines and refine the prevention and control measures of epidemic situation. According to the requirements of "Class B Management" and the characteristics of passenger flow in Spring Festival travel rush, the epidemic prevention and control guidelines for comprehensive transportation in Spring Festival travel rush and Covid-19 were formulated, and 14 epidemic prevention measures were defined in four aspects: disinfection and ventilation of stations and means of transport, protection of employees, publicity and guidance, and emergency response. Strengthen dispatch and supervision, guide all localities to strictly implement the requirements of the guidelines, disinfect and ventilate the passenger contact areas, facilities, equipment and means of transportation in the station, strengthen the health monitoring and protection of employees, and stop operations as soon as symptoms appear to ensure the safety of transportation and epidemic prevention.

　　The second is to optimize transportation service measures to minimize the risk of infection. Actively provide non-contact services such as online ticket purchase, e-ticket and self-service ticket inspection to reduce unnecessary personnel contact. Strengthen the passenger flow organization of passenger stations, guide the public to queue up in an orderly manner, disperse and wait for passengers, and reduce the concentration of people. Increase the input of transportation capacity during peak hours, operate "point-to-point" chartered cars and increase night buses according to the needs of the masses, strengthen the connection between different modes of transportation, improve the transportation service capacity, and reduce the gathering of people and long waiting. At the same time, some key passenger stations have also prepared necessary epidemic prevention materials such as antipyretics and thermometers to deal with emergencies.

　　The third is to organize supervision and inspection and implement the main responsibility of epidemic prevention and control. In order to implement the epidemic prevention measures of transportation, transportation departments at all levels have carried out various forms of comprehensive and special inspections. Before the Spring Festival, the Ministry of Transport, together with relevant departments, went to 13 provinces to carry out supervision and inspection, and urged transport operators to strictly implement epidemic prevention and control measures such as disinfection and ventilation of passenger stations and vehicles, transportation organization and personnel protection, and resolutely guard against the spread of the epidemic through transportation.

　　The fourth is to strengthen epidemic prevention propaganda and guide the masses to travel rationally at the wrong peak. Make full use of service guarantee windows such as "cars, boats, airplanes, roads, ports and stations" and media channels such as television, radio and internet, strengthen epidemic prevention propaganda, release travel information in time, guide the public to travel rationally and avoid peaks, remind passengers to avoid taking public transport when they are sick, wear masks regularly throughout the trip, actively reduce gathering, and be the first person responsible for their own health.

　　In addition, Han Jinghua stressed that at present, it is at the peak of returning after the holiday, reminding the majority of passengers that in order to be safe and healthy, they should wear masks all the way in the process of entering and leaving the passenger station and taking public transportation, and work together to prevent and control the traffic epidemic.

The little "Luo" whistled and set sail.

Luohe, Henan Province: "Handling Cases+Education" fully protects minors.

In November 2023, students from Luohe Experimental Primary School went to the Comprehensive Protection Center for Minors in the city to participate in the immersive practice of rule of law.

"There are legal provisions and judicial cases in this’ online celebrity Exhibition Hall’, and the prosecutor’s sister also taught us how to deal with bad people and prevent infringement." Recently, students from West Lake School in Luohe City, Henan Province, led by their teachers, came to the exhibition hall of rule of law education in Luohe City Comprehensive Protection Center for Minors and completed a unique study tour of rule of law.

The reporter learned that there are 4 exhibition areas and 16 themes in the exhibition hall of rule of law education in Luohe Comprehensive Protection Center for Minors, which integrates the functions of visiting, teaching, experience and practice by using situational experience and game interaction. With the help of the announcement (admonition) room, information (inquiry) room and psychological counseling room set up in the comprehensive case-handling area of the center, the procuratorate of Luohe City comprehensively carried out procuratorial case handling, psychological counseling, comprehensive assistance and parental education. Since its establishment in December 2019, the center has received more than 7,800 visitors and carried out 52 legal practice activities, which has not only become an important position for the mutual promotion of procuratorial handling and legal education, but also a "punching place" for legal education for minors in online celebrity.

Enhance the effectiveness of rule of law education

"I used to think that loving children is to make him worry-free, so I patronize working to earn money and rarely communicate with children." In June 2023, when accompanying the children to visit the exhibition hall of rule of law education in Luohe Comprehensive Protection Center for Minors, the mother of Ma, a minor involved in the crime, choked.

In July 2022, when handling a suspected theft case of Ma, the prosecutor of the Yancheng District Procuratorate of Luohe City found that Ma’s mother worked outside the home all the year round, and Ma had been living with her grandmother. Ma has been infected with Internet addiction due to the lack of family supervision. If he is not helped to quit Internet addiction, he still has the risk of committing crimes again.

In view of this, the procuratorate and the Women’s Federation jointly provided family education guidance to Ma’s mother, suggesting that she communicate with her children more, strengthen supervision and help Ma quit Internet addiction. After 10 months of investigation and assistance, on May 15, 2023, Ma was decided not to prosecute by the Yancheng District Procuratorate.

"In view of the problems such as the lack of family education and the absence of guardianship reflected in cases involving minors, we have produced courses such as" Talking about family education from the’ long season’ ",focusing on improving parents’ self-literacy, improving improper education methods, strengthening parent-child communication, and building a defense line for family guardianship, and reminding parents with the most real cases." Jun Hu, head of the unchecked department of Luohe City Procuratorate, said.

The reporter learned that Luohe Comprehensive Protection Center for Minors has a theater of rule of law and a mock trial. In view of the rule of law needs of students of different ages, combined with the legal blind spots and key points found in the practice of handling cases, prosecutors have produced more than 40 lecture courseware, scenario scripts and simulation cases on different topics such as preventing school bullying and preventing telecommunication network fraud, and actively fed back the course menu to the school for selection.

Since 2022, the procuratorate of Luohe City has given full play to the various functions of the Luohe Comprehensive Protection Center for Minors, and based on this, it has created the brand of "Yu Jian Future Xiao Luo" for minors’ procuratorial work. Since 2022, the Seventh Procuratorial Department of Luohe City Procuratorate has been awarded the National Advanced Collective for Safeguarding Women’s and Children’s Rights and Interests, the Henan Youth Rights and Interests Post and the National Youth Rights and Interests Post. The center was awarded as an excellent publicity and education base of the rule of law in Henan Province and a demonstration base of family education in Henan Province.

"This kind of case teaching and interactive experience based on procuratorial handling cases has changed the single mode of popularizing law, such as distributing brochures and teaching in class, realized the close combination of rule of law education and high-quality and efficient handling cases, and greatly improved the publicity effect of popularizing law." On August 17, 2023, Ning Yaqiu, deputy to the National People’s Congress and deputy director of the editorial office of Luohe Radio and Television Station in Henan Province, said at the unveiling ceremony of the Henan Provincial Procuratorate’s Comprehensive Protection Center for Minors.

Expand the source of supervision cases

In July 2022, Wang, an obstetrician and gynecologist in a hospital in Wuyang County, found that Xiao Yu (12 years old) was suspected of being sexually assaulted. Wang reported the case to the police at the first time according to the compulsory reporting system for cases against minors. The public security organs quickly launched an investigation, and the Wuyang County Procuratorate intervened in advance to guide the investigation according to law. In the end, the defendant was sentenced to three years in prison by the court.

"When the prosecutor gave us a mandatory report, he particularly emphasized the importance of medical staff fulfilling their mandatory reporting obligations in time, thus reducing the occurrence of re-infringement. Our hospital conscientiously implements the mandatory reporting system and incorporates it into the year-end assessment project of medical staff to jointly protect the healthy growth of minors. " The president of the hospital told the reporter.

"Since June 2022, we have concentrated on preaching the systems of compulsory reporting, prohibition of employment, and on-the-job inquiry to key groups such as front-line teachers and medical staff in Luohe Comprehensive Protection Center for Minors, and received a total of 7 clues about suspected cases of infringement on minors, including 2 criminal cases. The role of promoting and expanding the source of supervision by the rule of law is becoming prominent." Yuan Dong, deputy procurator-general of Luohe City Procuratorate, said.

The rule of law propaganda is not only an effective way to expand the source of supervision cases, but also an important part of minors’ procuratorial work and a keen antenna to participate in social governance. It is reported that Luohe City Procuratorate, in response to the clues about campus surrounding safety and school bullying found and collected in the popularization of law, actively cooperated with education, public security, market supervision and other departments to comprehensively manage the campus surrounding environment through discussion and consultation, procuratorial suggestions, and urging special actions, so as to eliminate all kinds of risks infringing on the legitimate rights and interests of minors in time. Since 2022, Luohe City Procuratorate has issued 12 procuratorial suggestions on the protection of minors according to law, promoted functional departments to carry out special rectification activities 14 times, inspected 428 merchants, ordered 30 businesses to suspend business for rectification, and investigated 9 illegal entertainment venues.

"Minors who commit crimes are the key targets of rule of law education." Yuan Dong said that since 2022, the procuratorial organs in Luohe City have focused on the juvenile delinquents, a special group of rule of law education, and paid attention to giving full play to the important role of targeted rule of law education in helping and saving juvenile delinquents, combining rule of law education with procuratorial admonition, behavior development and help and save, helping 55 juvenile delinquents to turn over a new leaf and reintegrate into society.

Optimize the mode of "handling cases+education"

"Children, please follow me to start this journey of the rule of law in the Winter Olympics and see what problems’ Jian Xiaowei’ encountered in the Winter Olympics and how to use legal weapons to protect himself." On the day of Children’s Day in 2023, more than 20,000 students from Luohe participated in an online live broadcast of the rule of law propaganda. Wang Hao, the prosecutor of the unchecked department of Luohe City Procuratorate, became the "anchor" and interpreted relevant legal knowledge from three aspects: rules and laws, cybercrime and campus violence. The number of praises in the live broadcast was as high as 500,000 times.

Luohe City Procuratorate adheres to the concept that "case handlers can be better lecturers", selects 81 procuratorial police officers with excellent political skills and professional skills in the city’s procuratorial organs to set up a professional propaganda team, and adjusts the content, methods and objects of propaganda at any time according to the changes in the characteristics of crimes involving minors, and promotes the deep integration of case interpretation and campus law popularization. At the same time, the hospital actively absorbs social propaganda talents, such as educators and children’s social workers, and changes "prosecutors speak for themselves" into "everyone speaks together", forming a big pattern of legal education for minors with distinct themes and their respective strengths; Actively unite the Youth League Committee, women’s federations, education, civil affairs and other units, and efficiently integrate Luohe City’s comprehensive protection center for minors, family education guidance stations, youth homes, and practice bases for rule of law education in primary and secondary schools, so as to achieve multi-field cooperation and one-stop service.

According to reports, since February 2023, Luohe City Procuratorate and relevant departments have carried out 13 sessions of "Youth Shaying and Law Walking" rule of law summer camp activities and "Candy Mom" parenting classes and educational lectures, bringing children of migrant workers, left-behind children in rural areas, parents, etc. into the scope of rule of law education, and including mental health education. At the same time, for some minors involved with outstanding psychological problems, The Communist Youth League Committee, educational and professional psychological institutions have carried out collective psychological counseling for 6 times and case intervention for 33 times, striving to achieve pre-prevention, timely intervention and timely punishment, and integrating standardized case handling, accurate publicity and diversified protection.

"The procuratorate of Luohe City will continue to focus on brand creation, optimize the mode of" case handling+education ",comprehensively strengthen the judicial protection of minors, crime prevention, rule of law education, etc., and sound the small number of comprehensive judicial protection for minors, making this" work with temperature "more practical and better, and supporting a blue sky of rule of law for the healthy growth of minors." Du Yongzhao, Party Secretary and Procurator-General of Luohe City Procuratorate, said.

(Our reporter Liu Lixin   Correspondent Huang Xindi)

　　Authors: Li Yongsheng, a special researcher at Socialism with Chinese characteristics Research Center for Theoretical System in Shaanxi Province and a professor at Marxism College of Xi ‘an Jiaotong University.

　　How can science and technology develop when the world is facing unprecedented changes and new challenges in economic globalization? On November 10th, the Supreme Leader of president sent a congratulatory letter to the opening of the first session of the Boao Forum for Asia International Forum on Science, Technology and Innovation, pointing out that in today’s world, a new round of scientific and technological revolution and industrial transformation is in the ascendant, which has brought profound changes to human development and provided a new path for solving and coping with global development problems and challenges. Science and technology should benefit all mankind. This profoundly clarifies the essence, purpose and value of science and technology, and points out the direction and provides follow-up for promoting scientific and technological progress and development.

　　The initial intention of science and technology is to benefit mankind.The development of science and technology has profoundly changed the fate of mankind and reconstructed social life. In today’s era of rapid development of science and technology, the importance of science and technology is more prominent. Tracing back to the history of scientific and technological development, it is not difficult to find that the initial intention of scientific and technological research is to explore the unknown, pursue the truth and benefit mankind. Newton said: "The sea of truth, let all the undiscovered things lie before my eyes and let me explore." Einstein said: "All I have to do is to serve truth and justice with my meager strength, even if I don’t like it." Bacon said: "The real and legitimate goal of science is nothing more than this: to give new discoveries and new strength to human life." Edison said: "My philosophy of life is work. I want to reveal the mystery of nature and benefit mankind." The wise words of these scientists and technical invention experts brilliantly tell the essence, purpose and value of scientific and technological research from different aspects, that is, to benefit mankind, which runs through the development of science and technology, becomes a strong background for the development of science and technology, and supports and promotes the progress and development of science and technology.

　　Only by benefiting mankind can science and technology keep its vitality forever.Science and technology is a social activity loaded with value, and it is not and cannot remain value neutral. Science and technology not only have the function of seeking truth, but also have the function of seeking goodness and beauty. People study science and develop technology for the purpose of improving life, creating a better world, enhancing human well-being and promoting social development. Reflecting on the course of the development of science and technology, those technologies that safeguard human survival, promote human well-being and create a better life often have strong vitality and development vitality, such as information technology, big data, artificial intelligence, life science, new materials, new energy technology, space technology, marine technology, etc., as well as the hybrid rice technology engaged by Chinese scientist Yuan Longping and the science and technology of treating malaria with traditional Chinese medicine engaged by Tu Youyou, which have brought many conveniences and benefits to human life, so they have strong vitality and vitality. On the contrary, those science and technology that are harmful to human dignity, rights and morality and endanger human life, health and survival and development are often despised by human beings and have no future. For example, the technology of human cloning, the technology of making nuclear weapons, and the artificial intelligence technology of making killing machines. Because these science and technology violate human morality, laws and ethics and challenge human rights, dignity and value, they have no market, no development soil and growth conditions, and it is difficult to sustain and achieve sustainable development. Human needs are the fundamental driving force for the development of science and technology, as Engels said: "Once there is a technological need in society, this need will push science forward more than ten universities."Among all kinds of human needs, the pursuit of truth, goodness and beauty is the deepest, most lasting, noblest and most meaningful need. Science and technology that tends to truth, goodness and beauty and benefits mankind will inevitably last forever, keep its vitality forever, and play its own value to the greatest extent.

　　Science and technology benefit mankind and need value navigation and social care.The essence and initial intention of science and technology is to benefit mankind and promote social development. The purpose of scientific and technological development is to care for, care for and promote human beings and promote their free and all-round development. However, in modern times, driven by the interests of capital chasing profits, science and technology have made great strides, resulting in environmental pollution, ecological destruction, accelerated species extinction, and various new types of germs constantly appearing, creating chaos such as nuclear weapons, nuclear leakage and pollution, and global warming, which directly threatened human survival and development. On the one hand, it shows that the development of science and technology is increasingly deviating from its essence and initial intention, which urgently needs human vigilance. On the other hand, it shows that science and technology will not automatically improve and benefit mankind. The healthy and sustainable development of science and technology needs value navigation and social care.

　　Science and technology have instrumental rationality and value rationality, which are dialectical unity. Instrumental rationality solves the problem of means and efficiency, that is, metaphysical problems; Value rationality solves the problem of purpose and meaning, that is, metaphysical problems. Among them, value rationality is more important, it is an organic part of scientific and technological rationality, it is related to the future and destiny of scientific and technological development, and it is the soul and commander of scientific and technological development. If we don’t solve the value rationality of science and technology, that is, the direction of scientific and technological innovation, the development of science and technology will lose its direction, lose itself and go astray, which will eventually affect its development. It can be seen that the development of science and technology is inseparable from the rational navigation of value. The "four orientations" put forward by the Chairman of the Supreme Leader, that is, persisting in facing the world’s scientific and technological frontier, facing the main battlefield of the economy, facing the country’s major needs, and facing people’s lives and health, are the value rationality that guides the development of science and technology, that is, the value navigation that promotes science and technology to benefit mankind, and lights up the way forward for the development of science and technology.

　　The cause of science and technology is not an isolated system, but a subsystem of the social system, which is restricted and influenced by many factors such as politics, economy, morality, law and culture. Therefore, in the complex environment of social differentiation, cultural diversity, different interests and diverse values, we must start from four aspects: system, policy, ethics and cultural environment to protect the initial intention of science and technology, care for the cause of science and technology and guide the development of science and technology from goodness to beauty. From the institutional level, we should integrate the scientific spirit of seeking truth, being pragmatic, rigorous and rational, and the scientific and technological values of caring for human destiny and benefiting mankind into the design of the scientific and technological system, constantly optimize the scientific and technological system, form a compulsory scientific and technological management system and social laws and regulations, restrain, guide and integrate scientific and technological behavior with institutional norms, guide scientific and technological workers to consciously practice their initial intentions in scientific and technological work, and guide scientific and technological behavior into the correct development track. From the policy level, it is necessary to establish a complete set of scientific and technological policy system that embodies the spirit and belief of science and technology, and form an effective operating mechanism to encourage scientific and technological workers to adhere to the belief of exploring truth and being brave in innovation, and to uphold the initial intention and perseverance of benefiting mankind through science and technology. Punish violations of scientific and technological norms, increase the social cost of violators, form a clear policy orientation of punishing evil and promoting good, make scientific and technological innovation follow strict norms, effectively correct scientific and technological misconduct, and ensure its orderly development and full of vitality.

　　Protecting the cause of science and technology depends on both heteronomy and self-discipline. Einstein said that science without conscience is the destruction of the soul, and scientists without social responsibility are moral decay and human sorrow. To this end, it is necessary to strengthen the construction of scientific and technological ethics. Establish and improve the governance system of scientific and technological ethics, improve the academic research mechanism of scientific and technological ethics governance, improve the supervision system of scientific and technological ethics, establish the self-discipline mechanism of scientific and technological personnel, form a scientific, standardized, effective and scientific and technological ethics system, strengthen the moral obligation and social responsibility of scientific and technological workers, and urge them to stress morality, style, ethics and self-cultivation, build a strong spiritual defense line of scientific and technological moral conscience, enhance self-discipline awareness and stick to the moral bottom line.

　　Protecting the development of science and technology cannot be separated from the nourishment of profound culture. Scientific culture is a deep soil that nourishes and irrigates the desire for exploration, curiosity, creativity, imagination and sense of responsibility. Vigorously develop science and culture, use science and culture to cultivate the initial heart and sharpen the mission, so that it is engraved in the souls of scientific and technological workers, melted into the blood, internalized in the heart and externalized in the line, so that science and technology can return to the duty of seeking truth and being pragmatic, pursuing goodness and beauty, creating a clean and upright scientific and technological environment, dispelling spiritual smog, resisting all kinds of temptations, stabilizing the rudder of scientific and technological behavior, and bringing more gospel to people.

　　The road to simplicity, people-oriented science and technology, guarding the initial intention of scientific and technological work, caring for the development of scientific and technological undertakings, carrying out international scientific research and cooperation, and making scientific and technological innovation better benefit mankind are the right path for the development of scientific and technological undertakings.

　 　 　 　 Instead of passing the exam, 17 2013 graduate students entered Hunan University, one of the best universities in Hunan, from six universities.

　　　　　　　　According to the latest ranking of "China Alumni Association Network", Hunan University ranks 34th, and all the six universities rank outside the top 100. The last of the six universities is Jishou University, which ranks 309th, but this university also has the largest number of 2013 graduate students transferred to Hunan University, with 5 students.

　　　　　　　　She Zuochen, director of the Graduate Department of Jishou University, said that the state stipulates that if there are special difficulties, you can transfer to another school, and the special situation of five students must be considered, "people-oriented".

　　　　　　　　The school of Hunan University also explained that the transfer procedures of 17 graduate students were compliant and there were no problems.

　　　　　　　　However, the transfer from ordinary universities to local famous schools and 17 graduate students at once, and the details of the transfer were not announced, which still caused controversy.

　　　　　　　　According to the data provided by the Hunan Provincial Department of Education, there are only 122 graduate students transferred from all universities in Hunan Province in the past decade.

　　　　　　　　Hunan University also realized that it was inappropriate, and made a new regulation after accepting 17 graduate students to transfer to another school, and will no longer accept the transfer applications of non-"985" university graduate students in the future.

Enter a prestigious school through transfer.

　　　　　　　　A netizen broke the news on the Internet that in 2014, Hunan University accepted 17 2013 graduate students from Jishou University, Hunan Agricultural University and other schools for transfer.

　　　　　　　　He said that these students did not go to the retest line of Hunan University in 2013, first entered non-key universities with low scores, then entered Hunan University in the name of further study, and then transferred their student status to Hunan University six months later to complete the whole process of phoenix nirvana.

　　　　　　　　The above-mentioned netizens questioned whether this situation is in line with state regulations and whether it is fair, and called on the Commission for Discipline Inspection to intervene.

　　　　　　　　The survey in The Paper confirmed that 17 graduate students did transfer from six universities in Hunan to Hunan University in early 2014. Among the 17 people, at least half of the students paid tuition fees to "study" at Hunan University before transferring to another school, and obtained credits. Its path is quite close to the description of netizens.

　　　　　　　　The Paper also found that among the 17 graduate students, some were admitted to the original university, but they did not study there.

　　　　　　　　For example, Yang, a graduate student in 2013, transferred from the business administration major of Central South University of Forestry and Technology to the business administration major of Hunan University. However, a 2013 graduate student majoring in business administration at Central South University of Forestry and Technology said that Yang’s name was on the roster at the time of reporting, but he had never seen Yang in his class.

　　　　　　　　The Paper contacted some graduate students who transferred to Hunan University, but they all refused the interview on the grounds of personal information and privacy.

　　　　　　　　The school of Hunan University responded that the transfer of 17 graduate students was carried out in accordance with national regulations and school procedures, and there was no problem.

　　　　　　　　As for the problem that some graduate students "pursue advanced studies" in Hunan University before transferring to another school, the school of Hunan University said that this is a case of mutual recognition of credits, that is, in order to share high-quality educational resources, each school allows students to take courses in the other school, and the school agrees with these credits.

　　　　　　　　Regardless of whether the procedures are in compliance, these 17 students did achieve a big leap in the school level through transfer.

　　　　　　　　According to the ranking of Chinese universities in 2015 selected by "China Alumni Association Network", the six universities where 17 graduate students were originally located were ranked outside the top 100, and Jishou University ranked 309th, far worse than Hunan University ranked 34th.

　　　　　　　　As far as the scores of postgraduate entrance examination are concerned, in 2013, the scores of literature postgraduates independently designated by Hunan University were 370, while the scores of literature postgraduates in six universities were unified "national line", with 350 for A-type candidates and 340 for B-type candidates (A and B are divided according to regions). The scores of literature postgraduate entrance examination in these six schools are 30-40 points different from those in Hunan University.

　　　　　　　　A graduate student in a famous university told The Paper that there are two specialized courses in the postgraduate examination independently proposed by universities, and the specialized courses in Hunan University are definitely much more difficult than those in six universities, so the actual gap is even greater than the difference in scores.

　　　　　　　　In addition, some graduate students were able to return to Changsha, the provincial capital, from Xiangtan and Jishou through transfer.　　

A winding path outside the exam

　　　　　　　　Every year, millions of students sprint for the postgraduate entrance examination, and eventually more than half a million students will be admitted to the corresponding schools according to their respective achievements.

　　　　　　　　However, after the unified postgraduate examination and admission are settled, there is still a winding path for the admitted graduate students to choose another school-transfer.

　　　　　　　　The winding path outside this exam is a "hole" left by the "Regulations on the Management of Students in Ordinary Colleges and Universities" issued by Order No.21 of the Ministry of Education.

　　　　　　　　In 2005, the Ministry of Education promulgated and implemented the "Regulations on the Management of Students in Colleges and Universities", which clearly stated that students should generally complete their studies in the admitted schools. If you are sick or have special difficulties and can’t continue studying in our school, you can apply for transfer.

　　　　　　　　However, there are four situations that clearly prohibit transfer: those who have been enrolled for less than one semester; When enrolling students, it is determined to be oriented and entrusted training; Should drop out of school; Other without justifiable reasons.

　　　　　　　　The "Regulations on the Management of Students in Ordinary Colleges and Universities" also clarifies the procedures for students to transfer to other schools: with the consent of the two schools, the transfer school can report to the local provincial education administrative department to confirm that the transfer reason is justified and can go through the transfer procedures; Inter-provincial transfer scholars shall be transferred from the provincial education administrative department of the transfer place to the provincial education administrative department of the transfer place, and go through the transfer procedures after confirming the transfer conditions.

　　　　　　　　In 2006, the Hunan Provincial Department of Education issued the Notice on Issues Related to Postgraduates’ Transfer, which added two more cases besides the cases in which the Regulations on the Management of Students in Ordinary Colleges and Universities clearly stated that transfer was not allowed: the graduate students were directly transferred to doctoral students; Does not meet the relevant provisions on graduate transfer from school to school.

　　　　　　　　Colleges and universities have also formulated their own "Measures for the Management of Postgraduate Student Status", which has made corresponding provisions on transfer.

　　　　　　　　For example, the Measures for the Management of Postgraduates’ Student Status in Hunan University basically follows the regulations of the Ministry of Education on transfer, but adds a new rule that no transfer is allowed "those who have been enrolled for more than one year".

　　　　　　　　The Measures for the Administration of Postgraduates’ Student Status in Hunan University also refines the examination and approval procedures for transfer. For example, it is stipulated that graduate students should submit a written application, and only after the tutor agrees to receive and transfer to the college (department) and the examination agrees, can they go through the registration formalities after being examined by the graduate school and approved by the principal in charge, and reported to the provincial education administrative department for approval.

　　　　　　　　Tang Zhenming, director of the Propaganda Department of Hunan University Party Committee and spokesperson, explained that after receiving the application, the graduate school will conduct the preliminary examination first, first of all, it must rule out several situations that the Ministry of Education stipulates that it is not allowed to transfer, and then "attend the meeting" after the preliminary examination.

　　　　　　　　"Attending the meeting" refers to taking the transfer application to the meeting of Hunan University Admissions Leading Group for discussion and voting. The enrollment leading groups are all school leaders, including the president, the vice president in charge of graduate students, the secretary of the school discipline inspection commission and the head of the graduate school.

　　　　　　　　Regarding the "cut" left by the Ministry of Education, a number of university graduate students told The Paper that some people have special circumstances and must be considered.

　　　　　　　　Regarding the unfairness caused by the transfer of scholars from ordinary universities to key schools, Vice President Liu of the Graduate School of Central South University of Forestry and Technology said that the transfer needs strict examination, so it will not cause large-scale unfairness.

　　　　　　　　Many university officials also emphasized to The Paper that the transfer of graduate students is only a small probability event, and very few graduate students transfer every year.

　　　　　　　　Even Hunan University, a "big family" of graduate students in Hunan Province, usually transfers in single digits every year, only in 2014, it soared to 17.

Special difficulties or discretionary factors?

　　　　　　　　The Ministry of Education’s Regulations on the Management of Students in Colleges and Universities clearly stipulates that students with "special difficulties" can apply for transfer, but it does not specify what "special difficulties" there are.

　　　　　　　　Colleges and universities also follow the concept of "special difficulties" of the Ministry of Education when formulating the regulations on student status management, and have not refined it.

　　　　　　　　Therefore, in practice, the "special difficulties" put forward by graduate students applying for transfer can be described in various ways.

　　　　　　　　She Zuochen, director of the Graduate Department of Jishou University, did not agree with The Paper to consult the application form of graduate students transferred from this school, saying that the materials had been filed and the administrator had taken a holiday.

　　　　　　　　He orally introduced the reasons why Liu and Luo, 2013 graduate students who transferred from this school to Hunan University, transferred to other schools.

　　　　　　　　Before Liu was admitted to Jishou University as a graduate student, she had studied in Hunan University for two years with master’s degree equivalent, so the school agreed to transfer her. "We consider for the students, after all, Hunan University is higher than our platform"; Luo is because his father who works in Changsha is in poor health and needs to be taken care of.

　　　　　　　　She Zuochen said that many transfer graduate students are the only children of single-parent families, and single parents are still sick. "Don’t think about it."

　　　　　　　　Yang and Xu, graduate students in 2013, transferred from Hunan University of Science and Technology to Hunan University.

　　　　　　　　Yao Jingcheng, deputy dean of the Graduate School of Hunan University of Science and Technology, said that Yang, who was admitted to the fine arts school, was allergic to oil painting, and the school did not have a design major, so she agreed to transfer to the design art school of Hunan University.

　　　　　　　　Since I’m allergic to oil painting, why did I apply for a postgraduate degree in fine arts at Hunan University of Science and Technology? The Paper contacted Yang through Weibo’s private letter, but the other party didn’t reply after asking about transfer and oil painting allergy.

　　　　　　　　The Paper found that Yang majored in online media art design at Hunan University.

　　　　　　　　As for Xu, Yao Jingcheng said that his application for transfer was due to financial difficulties, but did not specify what kind of financial difficulties it was. He only emphasized that Changsha, the provincial capital, had good economic conditions and many opportunities.

　　　　　　　　Three 2013 graduate students from Central South University of Forestry and Technology transferred to Hunan University. The graduate school of this school also rejected The Paper’s request to view the application form for graduate transfer, saying that only specialized departments can view students’ archives.

　　　　　　　　A teacher at the Graduate School of Central South University of Forestry and Technology said that most of the reasons for students’ transfer were because students found that their interests were inconsistent with the training priorities of the school after entering the school. "If you can’t learn, you will either drop out of school or transfer."

　　　　　　　　Tang Zhenming, a spokesman for Hunan University, also pointed out that students have a strong interest in a certain subject of Hunan University, and Hunan University will accept their application for transfer if they find that the other party has potential. He said that graduate students emphasize professional ability more than undergraduates.

　　　　　　　　Another situation is that students are not used to transferring the soil, water, diet and so on from the school.

　　　　　　　　Wang, a 2013 graduate student who transferred from Jishou University to Hunan University, told The Paper that the reason for the transfer was physical reasons, and he didn’t adapt to the mountainous climate in Jishou.

　　　　　　　　The name of Tang Zhen was once transferred from Hunan University to a Hebei graduate student because he couldn’t get used to the spicy Hunan food.

　　　　　　　　In practice, some universities will also consider the children of their own schools for transfer.

　　　　　　　　In short, the "special difficulties" stipulated by the Ministry of Education have evolved into various reasons in practice. Dean Liu of Central South University of Forestry and Technology summarized that any special circumstances can be applied, and then the school will review the reasons for the application.

　　　　　　　　In a sense, the "special difficulties" stipulated by the Ministry of Education have evolved into various discretionary factors in practice.

The opaque transfer process

　　　　　　　　Postgraduates who apply for transfer generally have to go through three levels, transfer out of school, transfer to school and the degree office of the provincial education department. If they transfer from other provinces, they have to go through the examination of the education departments of other provinces.

　　　　　　　　The internal audit process of the school is also very complicated, which generally requires the signature and consent of the tutor, the college, the graduate school and the leader of the competent school. For example, Hunan University also needs an enrollment leading group composed of many famous school leaders to hold a meeting to discuss and vote.

　　　　　　　　After the transfer and transfer to the school are agreed, they will be reported to the Academic Degree Office of the Provincial Department of Education. A staff member of the degree office said that the office is mainly responsible for confirmation and filing. Mainly confirm three contents: whether the universities on both sides agree, whether they are officially admitted students, and whether they are prohibited from transferring to other schools according to the regulations of the Ministry of Education.

　　　　　　　　However, there is no provision for publicity in the complicated and well-designed transfer review procedure.

　　　　　　　　The Paper searched the official website of Hunan University, but found no information related to transfer, and the transfer situation of 17 2013 graduate students was completely unknown.

　　　　　　　　Not only in Hunan University, but also in official website, six universities where 17 graduate students transferred, there is no information about these students’ transfer.

　　　　　　　　The Paper asked many graduate students from Changsha University of Science and Technology, Hunan University of Science and Technology, Central South University of Forestry and Technology, and Jishou University, all of whom said that they had never seen the transfer students notified or publicized by the school.

　　　　　　　　Several graduate students from Jishou University told The Paper that either the number of students was reduced during the class reunion, or they didn’t show up for a long time, and then they found out that some students had transferred to another school after asking each other.

　　　　　　　　In fact, it seems to be a common unspoken rule for all localities to keep the transfer information of graduate students in colleges and universities secret. Searching the keyword "graduate+transfer" casually on the Internet can’t find any public information about transfer students.

　　　　　　　　A staff member of the Academic Degree Office of Hunan Provincial Department of Education said that Decree No.21 of the Ministry of Education did not stipulate publicity.

　　　　　　　　A person from a university explained that because schools are not willing to transfer their graduate students, they will not promote it.

　　　　　　　　However, this kind of internal audit, which is not open to the public, is easy to make people guess. When it comes to transfer, the biggest magic weapon that many people think of is relationship.

　　　　　　　　A graduate student of Changsha University of Science and Technology told The Paper that transfer is "all done behind closed doors, not open and fair" and "mainly depends on your relationship".

　　　　　　　　Although Hunan University claimed that the transfer procedures of 17 graduate students were in compliance after self-examination, the number of transfer students in this session almost doubled than before, and it was not publicized, which eventually triggered online questioning.

　　　　　　　　In January 2014, the Admissions Leading Group of Hunan University held a meeting and decided to accept 17 2013 graduate students to transfer to Hunan University. "The meeting was very heated." In the same month, the group made a new regulation that it would no longer accept the transfer application of master students from non-"985" universities.

　　　　　　　　Tang Zhenming, director of the Propaganda Department of Hunan University Party Committee and spokesperson, said that this is because the school leaders want to ensure the quality of graduate students’ "import".

　　　　　　　　However, when accepting 17 graduate students from non-"985" universities, after a heated discussion, I immediately made a decision not to accept graduate students from non-"985" universities in the future, and the behind-the-scenes motivation made people think more.

　　　　　　　　Even the official of Hunan University does not deny that this decision has the consideration of excluding people from greeting and taking relationships. "I am too lazy to pay attention to you, just set a threshold of’ 985′."

　　　　　　　　As a result of the establishment of the threshold, none of the 2014 graduate students entered Hunan University through transfer.　　

Yuan Huiqin and China Philharmonic Orchestra

Asgen

　　BEIJING, Jan. 23 (Xinhua)-On Jan. 22, the "Dragon and Phoenix Becoming Lucky-Global Chinese New Year Music Festival", jointly sponsored by the National Centre for the Performing Arts and Phoenix Satellite TV, will be officially staged on the 29th day of the Lunar New Year (Jan. 24). The sudden cold wave can’t stop the enthusiasm of artists. In order to provide a rich music feast for Chinese compatriots around the world on the eve of the Spring Festival, members of the China Philharmonic Orchestra rushed to the rehearsal site with their musical instruments in the early morning. The original ecological tenor Gao Baoli, the Peking Opera artist Yuan Huiqin, who is known as "a thousand-faced old Dan", the piano rookie Wang Yujia, who is known as "the female version of Lang Lang in China", and Jiang Kemei, the most outstanding and popular all-rounder of Hu Qin in the contemporary era, and many other musicians on the performance list also arrived. The artists gathered together and rehearsed their carefully selected tracks for this global Chinese music festival.

　　"China melody, Western-style interpretation; The innovative arrangement technique of "traditional art and modern expression" has brought different passions to "top" artists. Although it is only a rehearsal, the artists’ serious input has not diminished at all. After a short run-in, they will interpret the classic songs in a seamless and vivid way. After exploring the details, the artists couldn’t help clapping their hands and encouraging each other.

　　Yuan Huiqin: Music Festival Seeking Artistic Standards

　　On the same day, the longest running-in piece was an excerpt from the Beijing Opera Symphony "The Woman of Yangmen". At this Chinese and Western Spring Music Festival, the Beijing Opera Symphony, which combines tradition and modernity, will undoubtedly be one of the biggest highlights. Although Yuan Huiqin, the singer of "Young Woman", once cooperated with the China Philharmonic Orchestra in a solo concert held in May this year, the symphony orchestra needs to "walk beside" the actors because of the complete lines and dramatic conflicts, as well as the dramatic changes in the singing rhythm of Beijing Opera, which is different from ordinary symphony performances, and each performance will be different according to the actors’ live performance.

　　Talking about the "trueness" between the two sides in the rehearsal of some beats, Yuan Huiqin, who was running between the rehearsal of the Spring Festival Evening and the rehearsal of the music festival, explained: "The global Chinese New Year Music Festival is a platform to spread the charm of China music and Chinese culture to the world. This high-end cultural performance requires very high artistic standards. In addition, the Beijing Opera Symphony is an innovation of the traditional Beijing Opera, which brings challenges to the cooperation between performers and orchestras, so we choose it carefully. There is no such difficulty in the program I will perform in the Spring Festival Evening. First, because the form is traditional Peking Opera, and second, because the Spring Festival Evening focuses on creating a festive atmosphere. "

　　Gao Baoli: The best state is reserved for Chinese people all over the world.

　　At the rehearsal scene, the original ecological singer Gao Baoli and the China Philharmonic Orchestra, who cooperated for the first time, brought a lot of surprises to each other, and the "Shandandan Blooms in Red" in one go was full of charm. "I have been looking forward to working with the Philharmonic Orchestra, hoping to bring innovative auditory enjoyment to the audience through the sublimation of folk music through symphony. In order to participate in the global Chinese New Year Festival and fully show the charm of China folk songs to the world through this platform, I have turned down many commercial performances during this time, and I hope to keep my best state for Chinese compatriots around the world. I am particularly happy that the cooperation with the Philharmonic Orchestra can be so tacit today. " Gao Baoli, who won warm applause from the Philharmonic Orchestra, said seriously.

　　Wang Yujia: Be yourself and don’t be a "female version of Lang Lang"

　　The first movement of Tchaikovsky’s Piano Concerto No.1 in B-flat minor and the fourth movement of the Yellow River are ups and downs, and ten slender fingers are performing classic songs like flowing water. Wang Yujia, a pianist on the piano bench, is totally different from the girl born after 80s who highlighted yellow hair and wore jeans and sneakers. The only similarity is her seriousness when watching other people’s performances under the stage.

　　The members of the Philharmonic Orchestra who rehearsed together could not believe that Wang Yujia had never played "Yellow River" in public. Wang Yujia, who was born in 1987 and went to the United States to study piano at the age of 14, is now famous in the European and American music circles. Wang Yujia, who just learned that the fourth movement of Yellow River would be performed at the music festival two weeks ago and returned to China for the Spring Festival for the first time in 14 years, said: "The Yellow River is a classic song representing China. I am very happy that the Global Chinese Music Festival will allow me to play this song for the audience of the motherland during the Spring Festival. Although it is the first time to cooperate with the Philharmonic Orchestra, it is not strange at all. There is a feeling of going home. On the day of the ceremony, I hope that I can present the magnificent momentum of the fourth movement, so that the global audience does not feel that a girl is playing. " After a song, sweating Wang Yujia spontaneously took off her sweater in public. Before doing this action, she did not forget to consult the consent of others present with her eyes.

　　Talking about the title of "China female version of Lang Lang" given to her by the domestic media, frank Wang Yujia said: "Lang Lang is a young pianist who is internationally renowned. I am very happy and grateful to them for calling me that. This is my affirmation. I am honored, but I still want to be myself and be the only Wang Yujia rather than being a replica of others."

　　Jiang Kemei: The spread of music in China should be gradual.

　　Jiang Kemei, a well-known Huqin performer who has cooperated with China Philharmonic Orchestra for many times, performed "Deep Night", which can be described as a combination of rigidity and softness, graceful and graceful atmosphere. The perfect cooperation between the two sides shows the oriental charm of Chinese folk music incisively and vividly. Jiang Kemei was deeply touched by the holding of the Chinese New Year Concert around the world: "In recent years, the foreign exchange of China music has been very frequent. It is of great significance for our China music to go further to the world to hold the Chinese New Year Festival for the whole world on such a special day as the Spring Festival."

　　Jiang Kemei, who has been invited to participate in large-scale international performances such as Cannes International Film Festival and Prague Spring Music Festival, and has cooperated with many internationally renowned orchestras and conductors, said that China’s music has a high international recognition at present: "I was once invited to perform two classic tracks, Deep Night and Horse Racing, with the world-famous Ottawa Symphony Orchestra, because it was the first time to perform oriental folk music together, and the conductor of the Ottawa Symphony Orchestra was very nervous. However, after a period of running-in, the performance was very successful, and the audience repeatedly asked to return. The perfect combination of erhu and violin brought a refreshing feeling to the audience and a great surprise to the conductor. After the performance, he patted me on the shoulder and told me that he would come to China to learn about China music. " Jiang Kemei also said that it is a very clever way to spread oriental music by combining Chinese and Western music in the global Chinese New Year Concert. From the combination of Chinese and Western music to the original flavor, the gradual infiltration and dissemination will give foreign audiences a process from understanding to acceptance to appreciation, which is an effective way for China music to go global.

　　Asgen: High-pitched Challenge to C 《 Qinghai-Tibet Plateau 》

　　Composer Zhang Qianyi once said: "Asgen’s temperament is very suitable for fresh, pure and distant songs." Each other is born from the heart, and the song is like a person. As simple and mellow as her singing, Asgen is reminiscent of the air with fragrant flowers and plants brewing on the plateau.

　　Asgen, who was still performing in Sichuan in the morning, flew back to Beijing at noon and rushed directly to the rehearsal hall of China Philharmonic Orchestra to participate in the rehearsal of "Dragon and Phoenix Becoming Lucky-Global Chinese Music Festival 2009". Despite some airsickness symptoms, as soon as the music started, Asgen was as excited as a different person.

　　On the stage of the global Chinese music festival, Asgen was the first Tibetan singer to sing. Therefore, Asgen chose the song "Qinghai-Tibet Plateau". The Qinghai-Tibet Plateau, which was created in 1997, combines the popular singing style with the Tibetan folk singing style, and the passionate and infectious melody sings the amorous and verve of the Qinghai-Tibet Plateau. This time, Asgen’s version of "Qinghai-Tibet Plateau" raised the music to C, and the singing was even more like the sound of nature.

　　"The first time I cooperated with the Philharmonic Orchestra, the difficulty of the songs also increased, so the pressure was also great. Although I have been singing on the stage for so many years, I still feel nervous when I think that Chinese in the world is watching me sing. " The first audition went well, but Asgen asked to sing again, and asked Xu Peidong, the artistic director of the Chinese Music Festival, the conductor of the orchestra and even the staff who stopped to listen on the sidelines to help her make suggestions and adjust the most perfect singing effect.

　　Xue Wei: China music should show off its skills to the world.

　　"The success of a musician is closely related to national strength and national prosperity. I have played abroad for so many years, and I have witnessed and experienced many changes. China has made great progress in these years, and the achievements of China music are obvious to all. Now China music can and should proudly show our achievements to the world. " Xue Wei, one of the most outstanding contemporary violin masters, the China musician who has won the highest and most prizes in international violin competitions so far, and the violinist who set the record for the youngest professor in royal academy of music 20 years ago, said so.

　　Perhaps it is to express this idea that Xue Wei suggested that the track of "Dragon and Phoenix Becoming Auspicious-Global Chinese Music Festival 2009" be selected as "Sunshine Shining in Tashkurgan". The Sunshine in Tashkurgan, which has a strong ethnic flavor, applies Tajik music materials and absorbs the playing techniques of China folk instruments, and is known as one of the most representative gorgeous and dazzling works of Chinese violin music.

　　Accompanying Xue Wei to complete this performance is the violin "Stradivari" made in 1751. "As a performer, every performance will try to attach some new content and new breakthroughs. Without new elements, there will be no new source of enthusiasm. I look forward to new breakthroughs on the stage of the National Centre for the Performing Arts. " In the cooperation with China Philharmonic Orchestra, Xue Wei and "Stradivari", the old partners, are full of passion, and the second degree and the decoration of semitone, the imitation of the four-tone chord of Dongbula and the unrestrained cadenza are outstanding.

Editor: Yan Bin

The Central Committee of the Communist Party of China’s Proposal on Formulating the Thirteenth Five-year Plan for National Economic and Social Development (hereinafter referred to as the "Proposal") adopted by the Fifth Plenary Session of the 18th CPC Central Committee puts forward that "improving the quality, efficiency and competitiveness of agriculture". China is a big agricultural country, and China’s agriculture is a big country agriculture. During the Thirteenth Five-Year Plan period, only by accelerating the development of modern agriculture and striving to improve the agricultural competitiveness of China’s big countries can we provide a solid foundation and strong guarantee for the transformation and upgrading of economic development and the building of a well-off society in an all-round way. Accelerating the development of modern agriculture and striving to improve agricultural competitiveness are also the needs to cope with the profound changes in the domestic and international environment for agricultural development. Domestically, economic development has entered a new normal, showing three characteristics: speed change, structural optimization and power conversion, which requires the simultaneous development of new industrialization, informationization, urbanization and agricultural modernization. In the simultaneous development of the four modernizations, agriculture is still a short board, and it is urgent to speed up the transformation of agricultural development mode and the adjustment of agricultural structure. From an international perspective, developed countries and regions are paying more and more attention to improving agricultural competitiveness, gradually eliminating direct subsidies to agriculture by adjusting laws and policies, and instead increasing support for agricultural business entities in the market field, so as to improve their competitiveness and promote the process of agricultural marketization. Facing the changes in the development environment at home and abroad, and implementing the spirit of the Fifth Plenary Session of the 18th CPC Central Committee, we should fill in the shortcomings of agriculture as soon as possible and strive to improve the agricultural competitiveness of China’s big countries.

Change the concept of agricultural development and pay more attention to the transformation of mode and structure.

The "Proposal" pointed out that to achieve the development goals during the "Thirteenth Five-Year Plan" period, solve development problems and cultivate development advantages, we must firmly establish the development concept of innovation, coordination, green, openness and sharing. The concept of development is the forerunner of development action. To develop modern agriculture and improve agricultural competitiveness under the new economic normal, we must firmly establish and implement the new development concept, and pay more attention to changing modes and adjusting structure.

The reason why we should pay more attention to changing the mode and adjusting the structure is because although agriculture is a traditional industry, its versatility is becoming increasingly obvious with the development of agriculture and economy and society. Modern agriculture should not only give play to traditional production functions and ensure food supply, but also give play to ecological and environmental protection, sightseeing and leisure, cultural inheritance and other functions to promote sustainable development. Only by establishing a new development concept and paying more attention to changing the mode and adjusting the structure can we accelerate the formation of a modern agricultural industrial chain pattern from field to table, form a modern agricultural industrial system with the integration of primary, secondary and tertiary industries, better lead the transformation of agricultural development mode and promote the improvement of agricultural development quality and efficiency. Therefore, we should speed up the transformation of extensive management methods that rely on resource consumption, strengthen the drive of agricultural scientific and technological innovation, and take the road of agricultural modernization with high output efficiency, product safety, resource conservation and environmental friendliness. On the basis of stabilizing grain production, we should scientifically determine the self-sufficiency level of major agricultural products, rationally arrange the development priorities of agricultural industries, give full play to the comparative advantages of various regions, industries and business models, promote the integration and interaction of primary, secondary and tertiary industries, and realize the transformation of agricultural production from production-oriented to consumption-oriented

Improve the innovation and extension system of modern agricultural science and technology and vigorously apply advanced science and technology.

The "Proposal" proposes to improve the modern agricultural science and technology innovation promotion system. At present, advanced science and technology plays an increasingly important supporting role in improving the comprehensive agricultural production capacity and overall competitiveness. In 2014, the contribution rate of agricultural science and technology progress in China has reached 56%. In the past, we put more emphasis on agricultural science and technology, such as improved varieties and good methods. Today, we propose to improve the innovation and extension system of modern agricultural science and technology and vigorously apply advanced technology, and its breadth and depth far exceed the cognitive scope of the past.

As far as biotechnology is concerned, it includes not only the traditional optimization of agricultural and livestock varieties, but also the modern biotechnology represented by transgenic technology. We should intensify technological research and development and industrialization, achieve the target requirements of high yield, high quality, high efficiency, ecology and safety, and effectively guarantee national food security and food safety. As far as equipment technology is concerned, it used to be more understood as a production tool to replace labor, but today it has become the basic production factor for developing modern agriculture, and the improvement of equipment technology level can greatly improve production efficiency and output benefit. Among them, special attention should be paid to the application of modern information technology. Modern information technologies such as agricultural Internet of Things, e-commerce, big data, cloud computing and global positioning system are playing an increasingly important leading and supporting role in agricultural production, processing and circulation. Especially the booming e-commerce will have a revolutionary impact on the circulation of agricultural products. Accordingly, to improve the modern agricultural science and technology innovation extension system, we need to think and plan from the strategic height that science and technology are the primary productive forces and important production factors, accelerate the establishment of modern agricultural science and technology innovation system, scientific and technological achievements transformation system, extension and application system, and accelerate the agricultural mechanization and informatization.

Constructing modern agricultural industrial system and optimizing the combination of resource elements

The "Proposal" pointed out that efforts should be made to build a modern agricultural industrial system. The main difference between modern agricultural industrial system and traditional agricultural industrial system is that the former focuses on forming a new factor combination mode through intensive investment and in-depth development of modern production factors such as financial capital, science and technology, organization and management, and promoting the steady improvement of total factor productivity and comprehensive quality of agricultural industry.

The role of modern agricultural industrial system in promoting agricultural competitiveness is mainly manifested in four aspects: specialization, scale, intensification and integration. First of all, specialized division of labor to improve labor productivity. According to the market demand and their own endowment, agricultural business entities focus on a certain field, variety or link that they are best at and most suitable for, and carry out specialized production and business activities, which can effectively improve labor production efficiency and business benefits. Secondly, large-scale production improves the land output rate. On the one hand, the moderate scale operation of land is convenient for arranging and utilizing land in pieces and improving the scale efficiency of agricultural production. On the other hand, connecting scattered land management entities through socialized services can transcend the boundaries between plots and families, promote the centralized investment of modern production factors such as capital, science and technology, management and equipment, and greatly form the spillover effect of scale management. Third, intensive management improves the efficiency of resource combination through the scientific, accurate, reduced and efficient utilization of various resource elements. Fourth, integrated development improves agricultural total factor productivity. In the development of modern agriculture, the absence of any factor of production will form a "short board effect". Only by building a modern agricultural industrial system, vigorously optimizing the combination of various production factors, and striving to realize the integrated development of production, processing, logistics and marketing, can agricultural competitiveness be effectively improved.

Change the mode of agricultural management and cultivate new agricultural management subjects

Agricultural management mode mainly includes two aspects: agricultural production mode and service mode, which is an important symbol of agricultural competitiveness of big countries. From the perspective of agricultural production mode, many new management modes, such as farm management, cooperative management and enterprise management, which are based on household contract management, have greatly promoted the commercialization, scale, intensification, specialization and organization of agricultural production. All kinds of new business entities have different functional orientation and comparative advantages, and have broad adaptability and development space. The interests of the main members of farm management are highly consistent, and the cost of labor supervision is low, which occupies a leading position in the production of breeding industry; Cooperative business entities organize scattered farmers, improve market bargaining position, reduce production and transaction costs, and have economies of scale in the integration and development of primary, secondary and tertiary industries, which is conducive to increasing farmers’ income; Enterprise management subjects have advanced technology and equipment, strong financing and anti-risk ability, and have obvious advantages in deep processing of agricultural products, logistics and distribution, carrying out innovative agricultural production and management activities, and improving agricultural added value.

From the perspective of agricultural service mode, various public welfare and business service organizations have flourished, and the professional, serialized and multi-level service models have been continuously innovated, initially forming an agricultural socialized service system led by government public service agencies and widely participated by multiple service subjects. In particular, some business service organizations provide services for farmers in the aspects of seed and fertilizer supply, agricultural machinery operation, production management, product sales, etc. by means of full trusteeship and semi-trusteeship, which neither changes the farmers’ contract relationship, but also ensures that the land is planted with people and the land can be planted well, showing great vitality in practice. It can be said that the agricultural management mode of "diversified business entities+whole-process socialized service" is an important path choice for China’s agricultural modernization and an important institutional innovation to adapt to China’s national conditions with a large population and a small population.

Cultivate new professional farmers and improve the quality of agricultural practitioners

The "Proposal" proposes to cultivate new professional farmers. This is an urgent need and an important support to solve the practical problem of "who will plant the land" and "how to plant the land well", improve the quality of agricultural practitioners and enhance the competitiveness of agriculture. The problem of "who will plant the land" is rooted in the weak competitiveness and low comparative income of agriculture, which is not unrelated to the non-professionalism of farmers. From the current practice and development trend, traditional farmers have lived in rural areas for generations, specializing in agricultural production, and are the basic groups that produce new professional farmers; After market experience, returning migrant workers have certain capital, technology and marketing capabilities, and are the core strength of new professional farmers; Rural junior and senior high school graduates have received systematic basic education and have strong ability to absorb and apply new knowledge and technology, which is the basic reserve of new professional farmers; The new farmers who master modern agricultural technology, have the concept of ecological agriculture and Internet thinking are the emerging groups of new professional farmers. Through targeted and classified vocational education and training, they can master their professional skills and improve their professional quality, become professional rural practical talents and management talents, and become new agricultural production subjects and service subjects to meet the requirements of modern agricultural development.

Grasp the national conditions in depth and give play to the comparative advantages of agriculture.

Compared with the United States, Canada, Australia and other countries with abundant agricultural resources, China’s total agricultural resources are insufficient and per capita resources are scarce. However, from the perspective of comparative advantage, there are many types of agricultural resources in China and other relative advantages, which have the conditions to improve agricultural competitiveness by giving full play to comparative advantages.

Generally speaking, China’s agricultural comparative advantages are mainly manifested in three aspects: First, comparative resource advantages. China has a vast territory, rich landforms, diverse climate, various types of agricultural resources and obvious characteristics of species diversity. For example, China’s higher plant species account for 10% of the world’s total, and mammal species account for 13%, both of which rank among the top in the world. We should make full use of this unique advantage of agricultural comparative resources. The second is comparative industrial advantages. The variety of agricultural resources in China determines the diversity of agricultural industrial structure in various places. All localities should base themselves on comparative advantages, develop different industries selectively and emphatically, and promote the formation of a modern agricultural industrial pattern with appropriate division of labor, reasonable layout and balanced total output throughout the country. The third is comparative competitive advantage. Compared with the United States, Canada and other countries, China is relatively competitive in non-resource products such as gardening and animal husbandry. Compared with Japan and South Korea, China is absolutely competitive in grain production. Giving full play to the comparative advantage of agriculture is to transform resource advantage into industrial advantage and industrial advantage into competitive advantage as soon as possible, and strive to improve the agricultural competitiveness of China’s big countries. (Zhang Hongyu)

Original title of this article: "Does the construction in the middle of the night bring dust rolling? These problems that plague citizens’ lives have been dealt with! 》

Dear friends,

The weekly [Echo] is coming again!

The mixer truck raises dust and the construction noise at night is loud?

Lack of road control, there are great security risks?

The school gate will be flooded whenever it rains, making it difficult to pass?

……

This week’s [Echo]

Continue to solve your problems!

reply

(No.39, 2018)

???

01

User message content

Longxi Mountain, Gaoyao Country Garden, rushed to work day and night, and 2 tons of cars were forbidden to pass through this section. The mixer still shuttled through Cologne Street at 2 or 3 in the morning, raising a lot of dust, and did not sprinkle water on the road to reduce dust, which had a great impact on the life and travel of nearby residents. The dust was rolling during the day and the noise was constant at night. I hope the relevant departments would pay attention to it.

Gaoyao district Committee office

answer

After verification, netizens reported that the situation was true. The construction unit has implemented water spraying and dust removal, but the frequency is not enough, and the dust removal effect is not ideal.

On October 26th, a joint working group was formed by the departments of housing, construction, environmental protection, transportation and traffic police in our district. The person in charge of the Longxi Mountain construction project in Country Garden and the person in charge of the construction unit were interviewed, and the situation reflected by the netizens’ messages was reported to the person in charge. The project construction party was required to strictly abide by various rules and regulations to carry out construction and production according to law, reasonably arrange the construction time, and limit the impact of environmental pollution problems such as dust and noise on the surrounding residents to the greatest extent. It is strictly forbidden to overload and carry vehicles. That night, traffic, traffic police and other departments set up cards around "Country Garden Longxi Mountain" to enforce the law, and rectified the traffic violations of dump trucks, and the rectification action received certain results.

On October 27th, the working group formed a rectification plan on relevant issues as follows:

First, it is forbidden for the construction unit to carry out construction at night (from 22:00 pm to 6:00 am the next day), and the District Housing and Construction Bureau is responsible for supervision. If the construction at night is found, it will be ordered to stop work immediately for rectification.

Second, because the traffic of trucks over 2 tons is restricted in Cologne Street, construction vehicles must bypass the construction site through other roads to avoid dust and noise disturbing people, and the traffic police and transportation departments are responsible for supervision; The District Traffic Police Brigade carries out technical maintenance and upgrade of monitoring equipment in Cologne Street, and the District Transportation Bureau urges the owner to install weighing equipment at the cargo loading site and assign special personnel to manage it.

Third, the construction unit is required to increase the frequency of sprinkling water to reduce the dust on the road section, and the district environmental protection bureau is responsible for supervision.

In the next step, housing, construction, environmental protection, transportation and other departments will establish a linkage mechanism, strengthen joint law enforcement, conduct night inspections, and severely punish violations found. The traffic police department will implement the service system and increase the patrol monitoring of this section by setting up cards and taking irregular measures.

02

User message content

1. On the Hengda Haoting section of Dinghu 321 National Road, even if you can enter the auxiliary road after turning around from west to east, there is no municipal road that can turn into Hengda Haoting. Every day, many people from Duanzhou to Dinghu turn around here and then take the path next to the gas station to enter Hengda Haoting Road. Because it is not a municipal road, the road surface is not maintained and there is no safety control, which has great security risks. It is recommended to improve it!

2. Since the construction of National Highway 321, Xinyuan No.1 Street in Dinghu District has been flooded in every heavy rain, especially when typhoons such as Tiange and Mangosteen arrive, and even the flooding depth is more than 1 meter. The surrounding residents have repeatedly reported their problems to the petition offices and sub-district offices, but they have not received any reply or rectification.

Dinghu district Committee office

answer

(I) About the problem of netizens reflecting the section of Evergrande Haoting.

It is understood that the path that enters Taihe gas station after the U-turn of Hengda Haoting section of National Highway 321 is not a municipal road, but is owned by the gas station. The person in charge of the commercial gas station has no intention to maintain the path at present. Next, our district will strengthen the safety supervision around this section in conjunction with the traffic police department to ensure the travel safety of surrounding residents.

(2) About netizens reflecting the flooding problem in Xinyuan Street.

It is understood that due to the influence of Typhoon Mangosteen No.22 this year, from September 16 to 18, heavy rain continued to fall in our area, with local heavy rain, and the maximum rainfall recorded at Kengkou was 269 mm. Xinyuan First Street was one of the areas where flooding occurred.

During Typhoon Mangosteen, the rainfall lasted for a long time and was heavy, which greatly exceeded the design capacity of urban sewers and drainage standards, making it difficult to drain the rainwater on the pavement in a short time, and flooding occurred in many places in the area to varying degrees. Xinyuan 1st Street mentioned in the letter must be flooded in heavy rain after the construction of National Highway 321. The reason is that the elevation of the road surface has been improved after the urbanization of National Highway 321, which makes Xinyuan 1st Street relatively low-lying and prone to flooding.

In view of this situation, our district will speed up the construction progress of Xinshengtian Canal, complete the project construction as soon as possible under the premise of ensuring the quality, and strive to put it into use as soon as possible, so as to reduce the drainage pressure of urban sewers and reduce the flooding problem during the torrential rain in the district. In addition, the water department of our district has organized the construction team to comprehensively clear the municipal sewers of Xinyuan First Street and surrounding roads to ensure the smooth drainage of sewers in this area. In the next step, our district will refer to the vertical of surrounding roads and other factors, and appropriately adjust the ground elevation of Xinyuan Street to minimize the problem of road surface water accumulation.

03

User message content

1. The road at the gate of xinhua primary school will be flooded whenever it rains, and the water depth is more than 20 centimeters. Primary school students cannot pass after school, so parents need to carry it. I hope the relevant departments will go to the field to investigate and study solutions.

2. Two fans on the Blue Sky Water Gathering Building of Duanzhou Shanghai City Phase II roared for 24 hours. Standing on the balcony, I felt my ears tingle. I didn’t even dare to open the doors and windows at home. I couldn’t sleep when I opened the windows. I have reported to various departments that no one has handled them many times. Blue Sky Shuihui is a clubhouse, which is opened so close to the community. It is not legal at all. A few days ago, I heard the voice of singing K in the middle of the night.

Duanzhou district government office

answer

(1) About the problem that netizens report that the road at the entrance of xinhua primary school will be flooded when it rains.

According to the field investigation, xinhua primary school is located on the land on the east side of Xinghu Avenue and the north side of Donghu Road, which is lower than the municipal roads. The road at the entrance of xinhua primary school belongs to the village road, and drainage pipes and wells have not been built around it. The urban drainage network management center regularly cleans and maintains the municipal drainage pipelines of Xinghu Avenue and Donghu Road to keep the pipelines unblocked. However, due to the lack of supporting drainage facilities and municipal drainage pipelines around xinhua primary school, and the fact that it is located in a low-lying area, rainwater cannot be drained when it rains, so it is easy to form flooding in rainy days. Our district has urged Huanggang Sub-district Office to organize Fenggang West Village to do its best to do the pumping and drainage work of this section in rainy days, and dredge the drainage channels to reduce the impact of stagnant water.

As the north side of xinhua primary school is reserved land for the expansion of Honghu Lake, it will be built by the Municipal Construction Bureau. The next step in this area will be drainage planning and construction together with Honghu Lake, which is transferred to the east. After the drainage network in this area is improved, the flooding problem of the road at the entrance of xinhua primary school can be completely solved.

(B) About the problem that netizens reported that the noise of Shanghai Blue Sky Water Club Phase II disturbed people.

Upon investigation, the name of the place mentioned in the complaint is Duanzhou Blue Sky Holiday Leisure Center (hereinafter referred to as "Blue Sky Shuihui Club") registered in the administrative department for industry and commerce. Duanzhou Sub-bureau of City Comprehensive Law Enforcement Bureau received a report on the disturbance caused by the fan noise of Blue Sky Shuihui Club in early June. After repeated urging by law enforcement officers on June 8, July 11, July 17 and August 6, the club moved two fans on the roof that were originally close to residential buildings to the direction of the road, and connected the extended air ducts of the fans to the sound isolation box, which significantly reduced the noise.

According to the situation reflected by netizens, Duanzhou Branch of the Municipal Comprehensive Law Enforcement Bureau and the District Cultural and Sports Bureau sent law enforcement officers to the scene for mediation. On-site inspection found that in order to reduce noise and avoid noise spread, the club also closed the kitchen window. On the morning of October 10th, law enforcement officers contacted the relevant complainants by telephone to inform them of the handling situation and will monitor the noise of Blue Sky Holiday Leisure Center together with the municipal environmental monitoring station. The complainant expressed satisfaction and understanding of our work.

In the next step, our district will urge Duanzhou Branch of the Municipal Comprehensive Law Enforcement Bureau and the Municipal Environmental Monitoring Station to monitor the noise of the clubhouse as soon as possible, and follow up according to the monitoring report.

04

User message content

The industrial zone on the west side of Xiangang Toll Station often uses night time to secretly discharge harmful waste gas and smoke, which causes people living nearby to have difficulty breathing and seriously affects their health! We have repeatedly complained ineffectively, and now we question whether there is a problem with the efforts of the functional departments to implement the national environmental protection policy.

Gaoyao district government

answer

Recently, the environmental protection bureau of our district has received two complaints about the waste gas pollution in the industrial zone on the west side of the Xian Gang toll station, which the district environmental protection bureau attaches great importance to. Since the beginning of this year, in response to the problem of waste gas pollution in Xiangang Industrial Zone, the District Environmental Protection Bureau has repeatedly conducted surprise inspections with the People’s Government of Xiangang Town on enterprises in the industrial zone, and filed investigations on 14 enterprises with environmental violations, which severely cracked down on environmental violations of enterprises in the region. At the same time, since the creation of our district, the government of Xiangang Town has established a grid system, strengthened supervision and inspection of enterprises in the industrial zone, and required relevant enterprises to implement the environmental management system.

After receiving complaints from the masses, on the evening of October 10, 2018, the law enforcement officers of the District Environmental Protection Bureau, together with the staff of Gaoyao District Environmental Protection Monitoring Station and third-party testing institutions, went to the complaint area to conduct supervision and inspection, and sampled and monitored the ambient air at the northeast side (near the exit of the toll station), south side (in the junior middle school) and west side of the complaint area, and will focus on tracking and inspecting the enterprises near the relevant area according to the results of the ambient air monitoring report.

At the same time, the enterprises involved in waste gas emission and producing at night (Zhaoqing Gaoyao Hongzhan Hardware Plastic Co., Ltd., Chongqing Gaoyao Jinyi Aluminum Co., Ltd., Zhaoqing Gaoyao Zhaoxing Industry and Trade Co., Ltd., etc.) were monitored for waste gas. During the inspection, law enforcement officers found that the exhaust gas collection in the drawing and granulating workshop of Hongzhan Hardware & Plastic Co., Ltd. in Gaoyao District of Zhaoqing City was not perfect and the workshop was irritating, so they immediately asked the company to stop production and rectify. The next day, the district environmental protection bureau issued a notice to the company to stop production and rectify, requiring the company to resume production after the rectification is completed and reported to the bureau for inspection.

In the next step, the District Environmental Protection Bureau will continue to strengthen the supervision and inspection of gas-related enterprises in the industrial zone on the west side of the Xiaogang toll station, and intensify inspections. Once suspected environmental violations are found, they will be seriously investigated and dealt with according to law. At the same time, the district environmental protection monitoring station and third-party testing institutions are required to increase the frequency of spot checks and monitoring of gas-related enterprises near the complaint area, and investigate the enterprises suspected of exceeding the standard discharge according to law.

That’s all for this issue.

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Zhaoqing fafa editorial department

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Editor-in-Chief Tang Qianyu

Editor Zeng Shanjie

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The incidence of malignant tumor is increasing year by year, which has become a common problem faced by human beings. Traditional treatment methods such as surgery, traditional chemotherapy and radiotherapy have always played a leading role in cancer treatment, but the effects of these treatments are limited. In particular, it is difficult for advanced patients to benefit from these treatments for a long time, nor can they fundamentally solve or change their quality of life. Therefore, researchers are increasingly focusing on the field of immunotherapy. Immunotherapy has brought new opportunities and hopes for the treatment of tumors, among which Immunocheckpoint inhibitors, therapeutic antibodies, tumor vaccines, immunomodulators, adoptive cell therapy, etc. Significantly improved the prognosis of cancer patients, and some patients with advanced cancer obtained long-term survival. In the past two years, many cellular immunotherapy have emerged and developed rapidly, which undoubtedly set off a wave of cancer treatment. So, is cell therapy reliable in treating cancer? In fact, immunotherapy has a history of more than 100 years, and it has only gradually entered the public’s field of vision in the last two years, and it has been absolutely recognized by the world oncology community. 　　

　　

A milestone in the history of cancer immunotherapy In 2013, Science magazine ranked the top ten scientific breakthroughs of the year, and immunotherapy topped the list. In recent years, immunotherapy is one of the hot spots in the research field of tumor treatment at home and abroad, and a large number of clinical studies have shown exciting results. Among them, Cellular immunotherapy uses the self-protection and killing ability of human immune system to achieve anti-tumor effect. Cells with immune function in patients are cultured and proliferated in vitro, and they are given the ability to attack tumor cells by technical means, and then they are imported into patients to realize their own anti-cancer. This therapyAgainst immune cells, not cancer cells.It is not as harmful to the patient’s health as surgery, radiotherapy and chemotherapy. Patients with early cancer can be treated directly, especially with the attack on residual cancer cells after surgery. Judging from the rapid development in scientific research and clinic in recent years, cellular immunotherapy is expected to become the fourth pillar of anticancer therapy in terms of accuracy, effectiveness and safety. Next, the small series of Cancer-free Home gives a general introduction and inventory of a variety of popular and emerging cellular immunotherapy in the biomedical industry, hoping to give cancer friends a general understanding of the general development process of this cancer treatment field.　

0one　　CAR-T cell therapy

CAR-T therapy is chimeric antigen receptor T cell immunotherapy, which is a new precise targeted therapy for treating tumors. T cells are activated by genetic engineering technology, and the positioning navigation device CAR (tumor chimeric antigen receptor) is installed to transform the ordinary "warrior" of T cells into "super warrior" CAR-T cells, Specially identify tumor cells in vivo and kill tumor cells efficiently. So as to achieve the purpose of treating malignant tumors. At present, with 2021, Aquilencel injection, Regioscel injection. It was approved for listing in China, in 2022.Cedarchiorense was approved for listing by FDA.CAR-T therapy is expected to enter the blowout period. Indeed, CAR-T technology has shown good curative effect in many hematological tumors, such as leukemia, lymphoma and multiple myeloma, and more than half of hematologic cancer patients who are on the verge of despair and have no cure have achieved good curative effect. 　

CAR-T cell therapy has been listed at home and abroad at present.

Although the clinical effect of CAR-T therapy on solid tumors is not satisfactory, and it has even been sung down by some people, in recent years, CAR-T therapy has made outstanding progress in the fields of gastric cancer, liver cancer and pancreatic cancer. Scholars at home and abroad have made various modifications to CAR-T, and constantly found new targets for the treatment of various solid tumors. 　 　

Clinical study on CAR-T therapy is out of the loop.

0one Gastric cancer and pancreatic cancer As the first CAR-T cell targeting Claudin18.2 in the world, CT041 emerged as early as the ASCO annual meeting in 2019. At that time, the total objective remission rate was 33.3%, which already surprised the world. Now the more remarkable curative effect is undoubtedly the icing on the cake! This clinical data shows a good treatment prospect for digestive system tumors!

Domestic CAR-T therapy CT041 first appeared in ESMO

Developed by Keji Pharmaceutical at the annual meeting of the European Society of Oncology (ESMO) in 2021.Targeting Claudin18.2(CLDN18.2)Autologous CAR-T candidate productsCT041Showing its presenceDigestive system tumorThe outstanding curative effect can be described as brilliant!

The research data is particularly eye-catching!

1.　All patients’The objective remission rate was 48.6%, and the disease control rate was 73%.All patients with gastric cancerThe total objective remission rate was 57.1%.

2.　Patients with gastric cancer who failed to receive at least 2 lines of treatment in the past:The objective remission rate was 61.1%, and the disease control rate was 83.3%.

3. And the overall tolerance is good!

As of March 3, 2022,CT041 became the first and only CAR-T cell candidate product in the world for the treatment of solid tumors, which entered the confirmatory phase II clinical trial.This is a milestone for CAR-T to conquer the solid tumor field. Congratulations!

In addition, there are many CAR-T cell therapies targeting CLDN18.2.0 2 liver cancer At present, the clinical trial targets of CAR-T in the treatment of liver cancer are mainlyGPC3 (phosphatidylinositol proteoglycan 3). The breakthrough research results completed by Professor Zhai Bo, director of the Department of Tumor Interventions, Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine, were published in the international authoritative journal Clinical Cancer Research on May 5, 2020. By July 24th, 2019, 13 patients had received CAR-GPC3 T cells with a median value of 19.9×108. All the patients are GPC3 positive, and they have received surgical treatment, local treatment or systemic treatment, and they all carry hepatitis B virus (HBV). Two patients achieved partial remission (PR). The 6-month, 1-year and 3-year survival rates of all patients were 50.3%, 42.0% and 10.5% respectively, and the median survival time (OS) was 278 days (39.7 weeks). At the ASCO annual meeting in 2021, Chinese medical researchers published the latest clinical research data of CAR-T drug targeting GPC3 (Ori-CAR-001) in the treatment of recurrent/refractory hepatocellular carcinoma for the first time. As of March 10, 2021, a total of 11 recurrent subjects who received cell infusion were included.All the subjects had advanced hepatocellular carcinoma, and none of them were effective after chemotherapy, TACE (transcatheter arterial chemoembolization) and targeted therapy.Of the 9 evaluable subjects,4 cases achieved partial remission (PR), 3 cases achieved disease stability (SD) and 2 cases developed disease progression (PD).The objective remission rate was 44%, and the disease control rate reached 78%..　

02　　Treatment of tumor infiltrating lymphocytes (TIL)

TILs therapy, simply speaking, is to separate and purify the lymphocytes in the tumor tissue after surgery, select the lymphocytes that can specifically resist cancer, and then amplify and activate them and reinfusion them. This kind of therapy has a history of more than 30 years, and it was first used for malignant melanoma. In recent years, it has given good data in many solid tumors such as cervical cancer and lung cancer.

This therapy is equivalent to pulling back veterans with combat experience directly from the battlefield. After a round of "political review" and "big competition" in professional ability, the spies and traitors are eliminated as far as possible, leaving the ones with the strongest fighting capacity, providing supplies, and then sending them back to the battlefield to continue fighting. Looking at the whole industry, the voice of "innovative therapy based on Tiles cells LN-144 (Lifelecel) is expected to be approved in 2022" is particularly loud. Tiles therapy, as an "ancient" cell therapy, is expected to usher in the first approved product this year, and its great potential in treating solid tumors can not be underestimated, with strong strength and relatively "out of the circle". TILs domain key node event 　 　 In 1982 　

Steven A.Rosenberg and others discovered for the first time that TILs can inhibit the metastasis of melanoma cells in patients.

　 1988 　

The earliest attempt of TILs in clinical treatment: TILs therapy for metastatic melanoma achieved an objective remission rate of 60%.

　 In 2011 　

Steven A.Rosenberg and others published a phase II clinical research data in Clinical Cancer Research: the objective remission rate (ORR) and complete remission rate (CR) of patients with melanoma treated by TILs were 56% and 24% respectively.

　 In 2012 　

Melinda Bachini, a patient with advanced intrahepatic cholangiocarcinoma, is called the first patient to achieve complete remission (CR) after TILs therapy.

　 2019 　

At the ASCO meeting, the clinical results of innovative therapies LN-145 and LN-144(Lifileucel) based on TILS cells in the treatment of cervical cancer and melanoma have attracted wide attention in the medical field.FDA awarded LN-145 breakthrough therapy recognition.

　 In 2021 　

Phase I clinical results of TILs cell therapy at AACR meeting: among 12 evaluable patients.Non-small cell lung cancer patientsMedium,TIL therapy can achieve a total remission rate of 25%, among whichTwo patients achieved lasting complete remission.

　 In 2021 　

At the annual meeting of tumor immunotherapy association (SITC), the clinical research results of LN-145 in the treatment of metastatic non-small cell lung cancer (mNSCLC) showed that in 28 cases,In patients with recurrent/refractory mNSCLC,After LN-145 monotherapy,The overall remission rate (ORR) was 21.4%(1 case of CR and 5 cases of PR, including 2 cases of PD-L1 negative tumors), 12 cases were stable, and the disease control rate (DCR) was 64.3%.

03　　TCR-T therapy

CAR-T cells and TCR-T cells belong to T cells modified by genetic engineering technology.Compared with CAR-T therapy, TCR-T therapy has unique advantages in the field of solid tumor treatment. TCR-T cell therapy can identify tumor-specific antigens from cell membrane surface or intracellular sources, and has entered clinical application from the initial basic immune research, showing initial efficacy in solid tumors, and has become the most likely T cell immunotherapy to make a breakthrough in the field of solid tumors!　

1、 TCR-T cell therapy in China has been approved for clinical use and has become a potential new therapy for HBV-related hepatocellular carcinoma!

At present, in addition to the global TCR-T in full swing in the research and development and clinical verification stage, China is also constantly breaking through innovation.

On December 22nd, 2021, CDE (Drug Evaluation Center) official website was able to inquire about the clinical application of "SCG101 Autologous T Cell Injection", which is a TCR-T cell therapy for specific hepatitis B virus (HBV) epitopes and a potential new therapy for HBV-related hepatocellular carcinoma (HCC).

▲ Image source: CDE official website

2、 Advanced liver cancer ushered in a new dawn! TCR-T therapy makes cancer patients completely relieved.

As early as 2020 International Hepatology Conference (ILC), ADP-A2AFP, a new TCR-T therapy for liver cancer based on T cells, caused quite a stir, and also made a new breakthrough in the new therapy for liver cancer.

Among the included patients,One patient showed a complete remission (CR) in cancer progression, and the AFP of the other participants also decreased to varying degrees.This means that the experiment has made progress, and it also shows that this therapy is effective for the treatment of advanced liver cancer.

　 　 　 　 　 　 　

All the 9 patients involved had undergone surgery and conventional radiotherapy and chemotherapy, but failed or became intolerant. Among the 4 patients who received the highest dose of treatment,One patient achieved complete remission, and CT scan showed that all the lesions in the patient disappeared, and it has lasted for more than half a year without any recurrence!

The best response of other patients (cohort 1, cohort 2) is stable. 1 patient in queue 2After one month of treatment, the volume of the primary lesion did not decrease, but the volume of mediastinal lymph node metastasis decreased obviously!　 　 　 　

Therefore, TCR-T therapy targeting AFP (alpha-fetoprotein) can kill tumor cells expressing AFP. Based on the positive results of this study, researchers are expected to expand the maximum dose to 5 billion cells, and we look forward to the publication of updated data of this study!

04　　CAR-NK therapy

In recent two years, in addition to CAR-T therapy, another new cancer cell therapy- Natural killer (NK) cell therapy It has also gradually attracted attention. The researchers said, NK cell As a cell anticancer therapy, it has more potential, and it may be safer, cheaper and faster. CAR-NK is to add a chimeric antibody to NK cells by genetic engineering that can recognize tumor cells and activate NK cells to kill tumor cells at the same time.　

one 　 The first "spot" CAR-NK clinical trial in China was approved by the Food and Drug Administration. On November 11, 2021, National Medical Products Administration Drug Evaluation Center passed an independent research and development in China. Mesothelin (MSLN) chimeric antigen receptor NK cells (CAR-NK) injection for the treatment of advanced epithelial ovarian cancer. Application for clinical trial of CAR-NK injection. According to the cancer-free home, This product is the first "spot" CAR-NK product of foreign origin in China. This also marks a new milestone in the research of immune cell drugs in the treatment of solid tumors in China!　

2　　The 1-year survival rate doubled, and the curative effect of CAR-NK therapy in solid tumor increased sharply.

Recently, the journal Clinical Oncology Research published a phase II clinical trial for lung cancer. Heat shock protein 70(Hsp70) is highly expressed in about 70% of middle and advanced lung cancer. NK cells are activated by Hsp70 in vitro, which is equivalent to making NK cells meet their future enemies in vitro, "making enemies" first, and then returning them to patients, so that NK cells can formally fight with cancer cells in vivo. This method of stimulating NK cells with antigen peptides in vitro and giving them certain specificity is a hot topic in recent years.

A total of 16 patients with stage III non-small cell lung cancer were enrolled in this clinical trial. One group received traditional chemotherapy combined with radiotherapy and chemotherapy, and the other group received chemotherapy combined with Hsp70 pre-stimulated NK cell reinfusion.

The results show that:The one-year survival rate can be doubled from 33% to 67% by Hsp70 pre-stimulated NK cell reinfusion therapy combined with traditional radiotherapy and chemotherapy, and the preliminary results are encouraging.

Next, Xiaobian shows a typical successful case in combination therapy, as shown in the figure:After 1~2 months of treatment, the lung tumor completely disappeared and the curative effect has been maintained for 18 months.

　 　　

In addition to the above-mentioned clinical studies at home and abroad, CAR-NK cells also have a good effect on glioblastoma and neuroblastoma, specifically recognizing and killing breast cancer cells with high efficiency, and have a remarkable effect on multiple myeloma.

05　　Dendritic cell vaccine

Cancer vaccine is a form of immunotherapy, which can prevent cancer from developing or kill existing tumors by stimulating or restoring the human immune system. Dendritic cell (DC) vaccine is a new biological therapy for malignant tumor in recent years, which has been paid more and more attention and recognized by oncologists. As an important member of the human immune defense system, Dendritic cells have the strongest antigen presenting function and are known as "sentinels" of the immune system. It is named because its cells extend outward with many dendritic protrusions. It mainly uses modern high-tech biotechnology to collect the peripheral blood of tumor patients, induce and cultivate a large number of dendritic cells in a short time in vitro, and equip them with immune cells that patients do not have, so as to accurately "target" and kill cancer cells. Not only that, It can also induce immune memory in patients, so that patients can obtain long-term anti-cancer effect.

DCVAC/LuCa is a dendritic cell vaccine developed by the United States for patients with non-small cell lung cancer.In a study on the first-line treatment of advanced lung cancer announced at the ASCO conference in 2019, DCVAC/LuCa vaccine combined with chemotherapy groupThe objective remission rate is 45%,The median overall survival time was 15.5 months, and the median progression-free survival time was 6.74 months.Reduce the risk of death by 46%!

In the Phase II clinical study of the latest novel dendritic cell vaccine DCVAC/LuCa (lung cancer dendritic cell vaccine) combined with standard carboplatin/pemetrexed in the treatment of advanced non-squamous cell (nsq) non-small cell lung cancer in 2022,The 1-year survival rate was 72.73% and the 2-year survival rate was 52.57%.By the time the data was published, the median overall survival time had not been reached. The median progression-free survival time was 8.0 months, and the objective remission rate was 31.82%.

　 Prostate cancer-Provenge vaccine 　

Provenge is the first vaccine approved for treatment in the United States, which initiated a new era of cancer immunotherapy.This is an autologous cell immunotherapy, which was approved by FDA on April 29, 2010 to treat asymptomatic or mild mCRPC. This approval marks the success of 20 years of unremitting efforts.In the United States, Provenge is the only FDA-approved immunotherapy for prostate cancer made from patients’ own immune cells.

　 Ovarian cancer-dcvac/ovca vaccine 　

At the 50th annual meeting of the Society of Gynecological Oncology (SGO) in 2019, the final result of SOV02, a phase II clinical trial, was announced: DCVAC/OvCa, an immunotherapy based on dendritic cells, was added to standard carboplatin and gemcitabine schemes for patients with recurrent, platinum-sensitive and epithelial ovarian cancer.It can prolong the overall survival (OS) of patients with advanced recurrent ovarian cancer by more than one year.andDCVAC/OvCa reduced the death risk of second-line treatment of ovarian cancer by 62%. The overall survival (OS) increased significantly by 13.4 months. The median progression-free survival rate (mPFS) increased by 1.8 months. The global phase III study will be launched soon.

Melanoma-TLPLDC vaccine

The subgroup analysis results of the phase IIb clinical trial of TLPLDC vaccine in the treatment of melanoma were published at the ASCO-SITC Clinical Immunooncology Conference in 2020.

In that population analysis follow the clinical research protocol (PT), compared with the comfort unit,The 24-month disease-free survival rate in TLPLDC treatment group was significantly improved (62.9% vs 34.8%), indicating that the relative risk of disease recurrence was reduced by nearly 50%.

In the population analysis of Intentional Treatment (ITT),There was no significant improvement in 24-month disease-free survival between TLPLDC treatment group and placebo group (38.5%)　vs　27%），But in this analysis,The improvement trend of 24-month overall survival rate (OS) was stronger (86.4% vs 75.1%)..

　 Kidney Cancer-Ilixadencel Vaccine 　

Ilixadencel is an allogeneic dendritic cell (DC) vaccine. Research shows that,Ilixadencel combined with targeted anticancer drug sunitinib(Sotan, common name: sunitinib)First-line treatment of newly diagnosed advanced metastatic renal cell carcinoma（mRCC）Compared with patients treated with sunitinib alone, the total remission rate is doubled, the complete remission rate is higher and the remission is more lasting!

　 Glioblastoma-AV-GBM-1 vaccine 　 On June 8, 2021, well-known foreign biomedical companies announced the release of phase II clinical trial data of their personalized cancer vaccine AV-GBM-1. The research shows that this new vaccine has great potential for prolonging the overall survival of newly diagnosed glioblastoma patients in the medium term. The median progression-free survival time of patients was 10.4 months, which was about 50% higher than the median progression-free survival time of 6.9 months in the landmark STUPP study, and established a nursing standard for newly diagnosed glioblastoma patients. 　 　 Non-small cell lung cancer-tedopi vaccine 　

On April 1st, 2020, a new anti-cancer vaccine, TEDPI, achieved positive results in the phase III clinical trial of non-small cell lung cancer. After the immune checkpoint inhibitor (PD-1) was resistant or failed, all patients in the group used TEDPI vaccine in the second or third line, and the overall survival rate for one year reached 46%, far exceeding the preset 25%!

A 54-year-old patient with advanced lung cancer has rapidly shrunk (from 39mm to 23mm) after five injections of the new lung cancer vaccine. At the time of reporting, his survival time has exceeded 20.6 months, and he is still being followed up.

06　　CIK cell therapy

　 CIK cells, that is, Cytokine-Induced Killer (CIK), are a new type of immunocompetent cells, which have strong proliferative ability and cytotoxicity, and have certain immune characteristics. Because this cell expresses both CD3 and CD56 membrane protein molecules, it is also called NK cell (natural killer cell)-like T lymphocyte, which has both the strong anti-tumor activity of T lymphocyte and the non-MHC-limited anti-tumor advantage of NK cell. If NK cells are the "first line of defense" to protect human health, then CIK cells are undoubtedly the "precision missiles" to kill tumor cells. Especially for patients after surgery or radiotherapy and chemotherapy, it can eliminate residual tiny metastatic lesions, prevent cancer cells from spreading and recurring, and improve immunity. Therefore, CIK cells are considered as the first choice for a new generation of adoptive cellular immunotherapy for tumors. Research progress of representative CIK cell therapy 　 　　

nasal pharyngeal cancer 　

Among 137 patients with nasopharyngeal carcinoma treated by CIK, 50% of them improved their survival time by 6-9 months, and among 137 patients treated by CIK, 50% of them delayed their tumor progression by 6-7 months.

　 liver cancer 　

Among the 819 patients with liver cancer treated by CIK, 50% of them improved their survival time by 13~25 months, and among the 819 patients treated by CIK, 50% of them delayed their tumor progression by 4~7 months.

　 ovarian cancer 　

Among 72 patients with ovarian cancer treated by CIK, 50% of them have improved their survival time by 24 months. Among 72 cases of ovarian cancer treated by CIK, 50% of ovarian cancer patients delayed their tumor progression by 14.5 months.

　

carcinoma of colon

Among 126 patients with colon cancer treated by CIK, 50% of them have a longer survival time of 30 months. Among 126 patients with colon cancer treated by CIK, 50% of them delayed their tumor progression by 14.5 months.

　 breast cancer 　

The probability that the survival time of 150 breast cancer patients treated with CIK can reach 5 years is increased to 85.7%; The probability of keeping breast cancer from recurring in 150 breast cancer patients treated with CIK within 5 years increased to 72.3%.

　 Solid tumor 　

Of the 31 patients treated with PD-1 antibody combined with DC-CIK, 2 patients’ tumors completely subsided and 5 patients’ tumors partially subsided. Of the above 7 patients, 6 patients’ effects can be maintained for 5 months. The tumors of the other 13 patients remained stable.

　 renal carcinoma 　

Among 43 patients with advanced renal cell carcinoma treated by CIK, 50% of them can delay the tumor progression to 14.7 months.

07　　CAR-M therapy　

In recent years, the study of macrophages has also been paid attention to by the industry. How to activate the anti-tumor activity of these macrophages is the direction that immunologists have been working hard. CD47, an immune checkpoint on macrophages, has become a very promising hot target in the field of tumor immunotherapy.

In a recent study published in Nature Biotechnology, researchers from perelman Medical College of the University of Pennsylvania and other research institutions may have an alternative to T cell therapy to overcome these challenges. Their research shows that genetic modification of macrophages (an immune cell that devours intruders in vivo) may be the key to developing effective cell therapy for solid tumors. They were able to confirm these genetically modified expressions. The macrophages of CAR (CAR-M) can kill tumors in human samples and mouse models in the laboratory and prolong their life.　 　

　　

CAR-M therapy is centered on macrophages, which devour invading cells instead of destroying them like T cells. T cells are more like Space Invaders games, while macrophages are more like Pac-Man games. Another major difference between macrophages and T cells is that they are the first responders of the body to virus infection. Historically, this poses a challenge in trying to genetically modify them to attack cancer, because macrophages are not easily transfected by standard viral vectors used in gene therapy and cell therapy.

In this experiment, the research team used genetic engineering technology to transform macrophages. They not only expressed CAR targeting HER2 antigen, but also were activated and differentiated into M1 macrophage types that promoted inflammation. In this way,These CAR-M cells can not only target tumor cells, but also change the microenvironment near tumors by secreting pro-inflammatory cytokines. They can also present tumor antigens to T cells and activate T cells’ immune response to tumors, which can be described as "killing three birds with one stone".

On March 18th, 2021, Carisma Company of the United States announced the completion of the first drug delivery to the subjects of CAR-M therapy (CT-0508) targeting Her2, marking a new era of CAR-M transformation therapy for solid tumors. In a word, taking macrophages as effector cells transformed by CAR is expected to reverse the tumor inhibitory microenvironment, so as to break through the obstacles of immune cell therapy in solid tumors.　

08　　CTL (cytotoxic T lymphocyte) therapy

What cell therapy can be used as an adjuvant therapy for the majority of patients with inoperable advanced cancer? In recent years, researchers have been developing new immunotherapy schemes for these patients, including CTL(cytotoxic T lymphocytes) technology. This technology mainly uses protein, which is unique to cancer cells and has no or low content in normal cells, as bait to select the truly anticancer lymphocytes in peripheral blood, and then further improve and amplify them in vitro, and then return them to patients. MTCA-CTL immunotherapy is a new generation of biological immunotherapy model introduced in China. While ensuring the expansion of non-MHC-restricted killer NK-T cells, directional expansion of HC-restricted CD8＋+specific CTL cells can make its proportion in cell products reach 60% ~ 70%. The combined effect of this killer cell makes the efficiency of killing tumor cells higher. 　

At present, the multi-target compound antigen peptide biological immunotherapy technology, which is undergoing the second phase of clinical trials in the Cancer Hospital of China Academy of Medical Sciences, is the fifth and brand-new generation of cellular immunotherapy technology, which can optimize the activation method of DC (dendritic cells) to enhance the killing effect of immune cells on tumor cells. At present, it has achieved good clinical results and I believe it will really benefit cancer patients.

【Mainly suitable for solid tumors.】Head and neck tumor, esophageal cancer, lung cancer, gastric cancer, breast cancer, liver cancer, membranous adenocarcinoma, colorectal cancer, ovarian cancer, uterine cancer, coma cancer, prostate cancer, malignant melanoma, sarcoma and partial malignant lymphoma.

If economic conditions permit and you want to consult MTCA-CTL therapy, you can contact.Cancer-free Home Medical Department (400-626-9916), a detailed assessment of the condition.

09　　CAR-NKT therapy

　 Natural killer T cells (NKT) are a group of special T cell subsets that express both T cell receptors (TCR) and NK cell receptors on the cell surface, and can produce a large number of cytokines. Such as IL-4 and INFγ. These cells can not only directly dissolve and kill tumor cells, but also play an anti-tumor role through indirect ways (secreted cytokines, activated immune cells, etc.). Recently, a phase I clinical trial jointly conducted by Baylor Medical College in Houston and Texas Children’s Hospital is evaluating a new treatment for children with recurrent neuroblastoma –CAR-NKT cell therapy is expected to break through this bottleneck. Phase I trial, code-named GINAKIT2, used CAR-NKT cells for the first time to treat recurrent neuroblastoma. Eleven children (1~21 years old, with an average age of 7 years old) were all recurrent/refractory high-risk neuroblastoma, with extensive metastasis and no better treatment plan in clinic. The results are very encouraging: Of the 11 advanced patients, The condition of 4 patients was stable, 2 patients achieved partial remission (tumor was obviously reduced), and one of them had complete remission (CR) after receiving the second CAR-NKT cell infusion. In safety, CAR-NKT is safer than CAR-T therapy. No dose-limiting toxicity was observed in the first 28 days after infusion.　

10　　Compound immune cell therapy

This technology will alsoSix kinds of cells, such as γδT cells, NK cells, NKT cells, killer T cells, dendritic cells and helper T cells.Activate, multiply 10 million to 20 million cells to 2 billion to 5 billion cells, and then inject them into patients. Cultivating such important immune cells at the same time greatly improves the therapeutic effect compared with single treatment.

Except for some leukemia and malignant lymphoma,It can be used for the treatment of most cancers, and has a good effect in refractory cancer types and advanced cancers. Besides,Compound immune cells also play a great role in improving immunity and strengthening the body.

Xiaobian has something to say

In recent years, due to the development of medical level, new cancer treatment methods have appeared one after another, among which cellular immunotherapy is in full swing, which brings new hope to cancer patients. According to the latest statistics, compared with patients with advanced lung cancer, gastric cancer and liver cancer who only receive surgery, radiotherapy and chemotherapy, adjuvant cellular immunotherapy can prolong the survival time of patients and significantly improve the data effect. In fact, tumor treatment is actually a complex "project", and it is difficult to achieve good results by relying solely on a certain treatment method. Tumor treatment needs the cooperation of various treatment methods to achieve the final victory in the fight against cancer.　

Hinako Sakurai starred in the Japanese TV series Bathing Girl.

People’s Daily Online, Tokyo, July 1st According to the report of Japanese channel comprehensive Japanese fashion entertainment website Modelpress, the Japanese drama "Bathing Girl" will be broadcast on July 15th in the Japanese drama Paravi column of Tokyo TV Station, which will be broadcast at 12: 58 every Wednesday night, starring actress Hinako Sakurai.

The drama tells the story of a female white-collar worker who loves to take a bath at home, Hayashi Nobuyoko, challenging all kinds of bathing methods, looking for "what is the best bathing method" and showing a bathing-centered lifestyle.

Now, influenced by the COVID-19 epidemic, the whole country advocates a new way of life, and the time for people to stay in their own homes is bound to increase. This drama is a series that can be operated in such a home time, with the theme of enjoying a bath. The play is adapted from the comic book of the same name of Shan Hao, which was serialized in the Weekly Big-comics Spirits from 2015 to 2016, and published three volumes of singles. It is a new comic book with the theme of bathing experience.

Sakurai plays the hero, Hayashi Nobuyoko. This is the first time Sakurai has appeared and starred in a TV series of Tokyo TV. Sakurai, who has read the original work, said: "I feel the same way about the comic book, and there are new discoveries. This work expands the possibility of taking a bath and is very interesting. Now because of the COVID-19 epidemic, everyone is looking for a reasonable way to use home time. I think this work is undoubtedly a very meaningful work. "

Screenwriters are Yosuke Masachi, who has been in charge of many late-night TV dramas of Tokyo TV, such as Renting People Who Do Nothing, Death Camp, and Yukori Nakamura, who has written TV dramas such as Metropolitan Police Department Search for a Section Chief and Nepenthes Dream. Directed by Jun’ichi Ishikawa, his main works include TV series Legal High, FRAGILE, movies April Fool’s Day, Love Swing and so on.

The play will premiere exclusively on the video website "Paravi". (Compile: Xue Yixiang Proofreading: Chen Jianjun) (Source:Modelpress)

(Copyright statement: This article is the content of the Japanese entertainment fashion website Modelpress exclusively authorized by People’s Daily Japan Channel. It is forbidden for any organization to use the content and pictures of the article in any form, including but not limited to reprinting and adaptation. )