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Ministry of Transport: Four measures to prevent and control the epidemic situation in Spring Festival travel rush and provide services.

  People’s Daily Online, Beijing, January 30 (Reporter Lu Jing) On January 30, the joint prevention and control mechanism of the State Council held a press conference. Han Jinghua, Deputy Director of the Transport Services Department of the Ministry of Transport, attended the conference and answered questions from reporters.

  This year, the passenger flow in Spring Festival travel rush has increased substantially. How can the Ministry of Transport do a good job in epidemic prevention and control and service? Han Jinghua introduced that there are four specific measures as follows:

  The first is to formulate and implement epidemic prevention guidelines and refine the prevention and control measures of epidemic situation. According to the requirements of "Class B Management" and the characteristics of passenger flow in Spring Festival travel rush, the epidemic prevention and control guidelines for comprehensive transportation in Spring Festival travel rush and Covid-19 were formulated, and 14 epidemic prevention measures were defined in four aspects: disinfection and ventilation of stations and means of transport, protection of employees, publicity and guidance, and emergency response. Strengthen dispatch and supervision, guide all localities to strictly implement the requirements of the guidelines, disinfect and ventilate the passenger contact areas, facilities, equipment and means of transportation in the station, strengthen the health monitoring and protection of employees, and stop operations as soon as symptoms appear to ensure the safety of transportation and epidemic prevention.

  The second is to optimize transportation service measures to minimize the risk of infection. Actively provide non-contact services such as online ticket purchase, e-ticket and self-service ticket inspection to reduce unnecessary personnel contact. Strengthen the passenger flow organization of passenger stations, guide the public to queue up in an orderly manner, disperse and wait for passengers, and reduce the concentration of people. Increase the input of transportation capacity during peak hours, operate "point-to-point" chartered cars and increase night buses according to the needs of the masses, strengthen the connection between different modes of transportation, improve the transportation service capacity, and reduce the gathering of people and long waiting. At the same time, some key passenger stations have also prepared necessary epidemic prevention materials such as antipyretics and thermometers to deal with emergencies.

  The third is to organize supervision and inspection and implement the main responsibility of epidemic prevention and control. In order to implement the epidemic prevention measures of transportation, transportation departments at all levels have carried out various forms of comprehensive and special inspections. Before the Spring Festival, the Ministry of Transport, together with relevant departments, went to 13 provinces to carry out supervision and inspection, and urged transport operators to strictly implement epidemic prevention and control measures such as disinfection and ventilation of passenger stations and vehicles, transportation organization and personnel protection, and resolutely guard against the spread of the epidemic through transportation.

  The fourth is to strengthen epidemic prevention propaganda and guide the masses to travel rationally at the wrong peak. Make full use of service guarantee windows such as "cars, boats, airplanes, roads, ports and stations" and media channels such as television, radio and internet, strengthen epidemic prevention propaganda, release travel information in time, guide the public to travel rationally and avoid peaks, remind passengers to avoid taking public transport when they are sick, wear masks regularly throughout the trip, actively reduce gathering, and be the first person responsible for their own health.

  In addition, Han Jinghua stressed that at present, it is at the peak of returning after the holiday, reminding the majority of passengers that in order to be safe and healthy, they should wear masks all the way in the process of entering and leaving the passenger station and taking public transportation, and work together to prevent and control the traffic epidemic.

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It is the right way for science and technology to benefit mankind.

  Authors: Li Yongsheng, a special researcher at Socialism with Chinese characteristics Research Center for Theoretical System in Shaanxi Province and a professor at Marxism College of Xi ‘an Jiaotong University.

  How can science and technology develop when the world is facing unprecedented changes and new challenges in economic globalization? On November 10th, the Supreme Leader of president sent a congratulatory letter to the opening of the first session of the Boao Forum for Asia International Forum on Science, Technology and Innovation, pointing out that in today’s world, a new round of scientific and technological revolution and industrial transformation is in the ascendant, which has brought profound changes to human development and provided a new path for solving and coping with global development problems and challenges. Science and technology should benefit all mankind. This profoundly clarifies the essence, purpose and value of science and technology, and points out the direction and provides follow-up for promoting scientific and technological progress and development.

  The initial intention of science and technology is to benefit mankind.The development of science and technology has profoundly changed the fate of mankind and reconstructed social life. In today’s era of rapid development of science and technology, the importance of science and technology is more prominent. Tracing back to the history of scientific and technological development, it is not difficult to find that the initial intention of scientific and technological research is to explore the unknown, pursue the truth and benefit mankind. Newton said: "The sea of truth, let all the undiscovered things lie before my eyes and let me explore." Einstein said: "All I have to do is to serve truth and justice with my meager strength, even if I don’t like it." Bacon said: "The real and legitimate goal of science is nothing more than this: to give new discoveries and new strength to human life." Edison said: "My philosophy of life is work. I want to reveal the mystery of nature and benefit mankind." The wise words of these scientists and technical invention experts brilliantly tell the essence, purpose and value of scientific and technological research from different aspects, that is, to benefit mankind, which runs through the development of science and technology, becomes a strong background for the development of science and technology, and supports and promotes the progress and development of science and technology.

  Only by benefiting mankind can science and technology keep its vitality forever.Science and technology is a social activity loaded with value, and it is not and cannot remain value neutral. Science and technology not only have the function of seeking truth, but also have the function of seeking goodness and beauty. People study science and develop technology for the purpose of improving life, creating a better world, enhancing human well-being and promoting social development. Reflecting on the course of the development of science and technology, those technologies that safeguard human survival, promote human well-being and create a better life often have strong vitality and development vitality, such as information technology, big data, artificial intelligence, life science, new materials, new energy technology, space technology, marine technology, etc., as well as the hybrid rice technology engaged by Chinese scientist Yuan Longping and the science and technology of treating malaria with traditional Chinese medicine engaged by Tu Youyou, which have brought many conveniences and benefits to human life, so they have strong vitality and vitality. On the contrary, those science and technology that are harmful to human dignity, rights and morality and endanger human life, health and survival and development are often despised by human beings and have no future. For example, the technology of human cloning, the technology of making nuclear weapons, and the artificial intelligence technology of making killing machines. Because these science and technology violate human morality, laws and ethics and challenge human rights, dignity and value, they have no market, no development soil and growth conditions, and it is difficult to sustain and achieve sustainable development. Human needs are the fundamental driving force for the development of science and technology, as Engels said: "Once there is a technological need in society, this need will push science forward more than ten universities."Among all kinds of human needs, the pursuit of truth, goodness and beauty is the deepest, most lasting, noblest and most meaningful need. Science and technology that tends to truth, goodness and beauty and benefits mankind will inevitably last forever, keep its vitality forever, and play its own value to the greatest extent.

  Science and technology benefit mankind and need value navigation and social care.The essence and initial intention of science and technology is to benefit mankind and promote social development. The purpose of scientific and technological development is to care for, care for and promote human beings and promote their free and all-round development. However, in modern times, driven by the interests of capital chasing profits, science and technology have made great strides, resulting in environmental pollution, ecological destruction, accelerated species extinction, and various new types of germs constantly appearing, creating chaos such as nuclear weapons, nuclear leakage and pollution, and global warming, which directly threatened human survival and development. On the one hand, it shows that the development of science and technology is increasingly deviating from its essence and initial intention, which urgently needs human vigilance. On the other hand, it shows that science and technology will not automatically improve and benefit mankind. The healthy and sustainable development of science and technology needs value navigation and social care.

  Science and technology have instrumental rationality and value rationality, which are dialectical unity. Instrumental rationality solves the problem of means and efficiency, that is, metaphysical problems; Value rationality solves the problem of purpose and meaning, that is, metaphysical problems. Among them, value rationality is more important, it is an organic part of scientific and technological rationality, it is related to the future and destiny of scientific and technological development, and it is the soul and commander of scientific and technological development. If we don’t solve the value rationality of science and technology, that is, the direction of scientific and technological innovation, the development of science and technology will lose its direction, lose itself and go astray, which will eventually affect its development. It can be seen that the development of science and technology is inseparable from the rational navigation of value. The "four orientations" put forward by the Chairman of the Supreme Leader, that is, persisting in facing the world’s scientific and technological frontier, facing the main battlefield of the economy, facing the country’s major needs, and facing people’s lives and health, are the value rationality that guides the development of science and technology, that is, the value navigation that promotes science and technology to benefit mankind, and lights up the way forward for the development of science and technology.

  The cause of science and technology is not an isolated system, but a subsystem of the social system, which is restricted and influenced by many factors such as politics, economy, morality, law and culture. Therefore, in the complex environment of social differentiation, cultural diversity, different interests and diverse values, we must start from four aspects: system, policy, ethics and cultural environment to protect the initial intention of science and technology, care for the cause of science and technology and guide the development of science and technology from goodness to beauty. From the institutional level, we should integrate the scientific spirit of seeking truth, being pragmatic, rigorous and rational, and the scientific and technological values of caring for human destiny and benefiting mankind into the design of the scientific and technological system, constantly optimize the scientific and technological system, form a compulsory scientific and technological management system and social laws and regulations, restrain, guide and integrate scientific and technological behavior with institutional norms, guide scientific and technological workers to consciously practice their initial intentions in scientific and technological work, and guide scientific and technological behavior into the correct development track. From the policy level, it is necessary to establish a complete set of scientific and technological policy system that embodies the spirit and belief of science and technology, and form an effective operating mechanism to encourage scientific and technological workers to adhere to the belief of exploring truth and being brave in innovation, and to uphold the initial intention and perseverance of benefiting mankind through science and technology. Punish violations of scientific and technological norms, increase the social cost of violators, form a clear policy orientation of punishing evil and promoting good, make scientific and technological innovation follow strict norms, effectively correct scientific and technological misconduct, and ensure its orderly development and full of vitality.

  Protecting the cause of science and technology depends on both heteronomy and self-discipline. Einstein said that science without conscience is the destruction of the soul, and scientists without social responsibility are moral decay and human sorrow. To this end, it is necessary to strengthen the construction of scientific and technological ethics. Establish and improve the governance system of scientific and technological ethics, improve the academic research mechanism of scientific and technological ethics governance, improve the supervision system of scientific and technological ethics, establish the self-discipline mechanism of scientific and technological personnel, form a scientific, standardized, effective and scientific and technological ethics system, strengthen the moral obligation and social responsibility of scientific and technological workers, and urge them to stress morality, style, ethics and self-cultivation, build a strong spiritual defense line of scientific and technological moral conscience, enhance self-discipline awareness and stick to the moral bottom line.

  Protecting the development of science and technology cannot be separated from the nourishment of profound culture. Scientific culture is a deep soil that nourishes and irrigates the desire for exploration, curiosity, creativity, imagination and sense of responsibility. Vigorously develop science and culture, use science and culture to cultivate the initial heart and sharpen the mission, so that it is engraved in the souls of scientific and technological workers, melted into the blood, internalized in the heart and externalized in the line, so that science and technology can return to the duty of seeking truth and being pragmatic, pursuing goodness and beauty, creating a clean and upright scientific and technological environment, dispelling spiritual smog, resisting all kinds of temptations, stabilizing the rudder of scientific and technological behavior, and bringing more gospel to people.

  The road to simplicity, people-oriented science and technology, guarding the initial intention of scientific and technological work, caring for the development of scientific and technological undertakings, carrying out international scientific research and cooperation, and making scientific and technological innovation better benefit mankind are the right path for the development of scientific and technological undertakings.

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Hunan University accepted the transfer of 17 graduate students from other universities, and the transfer process was accused of black-box operation.

Five graduate students from Jishou University transferred to Hunan University. The Paper reporter Li Yunfang        

        Instead of passing the exam, 17 2013 graduate students entered Hunan University, one of the best universities in Hunan, from six universities.

        According to the latest ranking of "China Alumni Association Network", Hunan University ranks 34th, and all the six universities rank outside the top 100. The last of the six universities is Jishou University, which ranks 309th, but this university also has the largest number of 2013 graduate students transferred to Hunan University, with 5 students.

        She Zuochen, director of the Graduate Department of Jishou University, said that the state stipulates that if there are special difficulties, you can transfer to another school, and the special situation of five students must be considered, "people-oriented".

        The school of Hunan University also explained that the transfer procedures of 17 graduate students were compliant and there were no problems.

        However, the transfer from ordinary universities to local famous schools and 17 graduate students at once, and the details of the transfer were not announced, which still caused controversy.

        According to the data provided by the Hunan Provincial Department of Education, there are only 122 graduate students transferred from all universities in Hunan Province in the past decade.

        Hunan University also realized that it was inappropriate, and made a new regulation after accepting 17 graduate students to transfer to another school, and will no longer accept the transfer applications of non-"985" university graduate students in the future.

Enter a prestigious school through transfer.

        A netizen broke the news on the Internet that in 2014, Hunan University accepted 17 2013 graduate students from Jishou University, Hunan Agricultural University and other schools for transfer.

        He said that these students did not go to the retest line of Hunan University in 2013, first entered non-key universities with low scores, then entered Hunan University in the name of further study, and then transferred their student status to Hunan University six months later to complete the whole process of phoenix nirvana.

        The above-mentioned netizens questioned whether this situation is in line with state regulations and whether it is fair, and called on the Commission for Discipline Inspection to intervene.

        The survey in The Paper confirmed that 17 graduate students did transfer from six universities in Hunan to Hunan University in early 2014. Among the 17 people, at least half of the students paid tuition fees to "study" at Hunan University before transferring to another school, and obtained credits. Its path is quite close to the description of netizens.

        The Paper also found that among the 17 graduate students, some were admitted to the original university, but they did not study there.

        For example, Yang, a graduate student in 2013, transferred from the business administration major of Central South University of Forestry and Technology to the business administration major of Hunan University. However, a 2013 graduate student majoring in business administration at Central South University of Forestry and Technology said that Yang’s name was on the roster at the time of reporting, but he had never seen Yang in his class.

        The Paper contacted some graduate students who transferred to Hunan University, but they all refused the interview on the grounds of personal information and privacy.

        The school of Hunan University responded that the transfer of 17 graduate students was carried out in accordance with national regulations and school procedures, and there was no problem.

        As for the problem that some graduate students "pursue advanced studies" in Hunan University before transferring to another school, the school of Hunan University said that this is a case of mutual recognition of credits, that is, in order to share high-quality educational resources, each school allows students to take courses in the other school, and the school agrees with these credits.

        Regardless of whether the procedures are in compliance, these 17 students did achieve a big leap in the school level through transfer.

        According to the ranking of Chinese universities in 2015 selected by "China Alumni Association Network", the six universities where 17 graduate students were originally located were ranked outside the top 100, and Jishou University ranked 309th, far worse than Hunan University ranked 34th.

        As far as the scores of postgraduate entrance examination are concerned, in 2013, the scores of literature postgraduates independently designated by Hunan University were 370, while the scores of literature postgraduates in six universities were unified "national line", with 350 for A-type candidates and 340 for B-type candidates (A and B are divided according to regions). The scores of literature postgraduate entrance examination in these six schools are 30-40 points different from those in Hunan University.

        A graduate student in a famous university told The Paper that there are two specialized courses in the postgraduate examination independently proposed by universities, and the specialized courses in Hunan University are definitely much more difficult than those in six universities, so the actual gap is even greater than the difference in scores.

        In addition, some graduate students were able to return to Changsha, the provincial capital, from Xiangtan and Jishou through transfer.  

A winding path outside the exam

        Every year, millions of students sprint for the postgraduate entrance examination, and eventually more than half a million students will be admitted to the corresponding schools according to their respective achievements.

        However, after the unified postgraduate examination and admission are settled, there is still a winding path for the admitted graduate students to choose another school-transfer.

        The winding path outside this exam is a "hole" left by the "Regulations on the Management of Students in Ordinary Colleges and Universities" issued by Order No.21 of the Ministry of Education.

        In 2005, the Ministry of Education promulgated and implemented the "Regulations on the Management of Students in Colleges and Universities", which clearly stated that students should generally complete their studies in the admitted schools. If you are sick or have special difficulties and can’t continue studying in our school, you can apply for transfer.

        However, there are four situations that clearly prohibit transfer: those who have been enrolled for less than one semester; When enrolling students, it is determined to be oriented and entrusted training; Should drop out of school; Other without justifiable reasons.

        The "Regulations on the Management of Students in Ordinary Colleges and Universities" also clarifies the procedures for students to transfer to other schools: with the consent of the two schools, the transfer school can report to the local provincial education administrative department to confirm that the transfer reason is justified and can go through the transfer procedures; Inter-provincial transfer scholars shall be transferred from the provincial education administrative department of the transfer place to the provincial education administrative department of the transfer place, and go through the transfer procedures after confirming the transfer conditions.

        In 2006, the Hunan Provincial Department of Education issued the Notice on Issues Related to Postgraduates’ Transfer, which added two more cases besides the cases in which the Regulations on the Management of Students in Ordinary Colleges and Universities clearly stated that transfer was not allowed: the graduate students were directly transferred to doctoral students; Does not meet the relevant provisions on graduate transfer from school to school.

        Colleges and universities have also formulated their own "Measures for the Management of Postgraduate Student Status", which has made corresponding provisions on transfer.

        For example, the Measures for the Management of Postgraduates’ Student Status in Hunan University basically follows the regulations of the Ministry of Education on transfer, but adds a new rule that no transfer is allowed "those who have been enrolled for more than one year".

        The Measures for the Administration of Postgraduates’ Student Status in Hunan University also refines the examination and approval procedures for transfer. For example, it is stipulated that graduate students should submit a written application, and only after the tutor agrees to receive and transfer to the college (department) and the examination agrees, can they go through the registration formalities after being examined by the graduate school and approved by the principal in charge, and reported to the provincial education administrative department for approval.

        Tang Zhenming, director of the Propaganda Department of Hunan University Party Committee and spokesperson, explained that after receiving the application, the graduate school will conduct the preliminary examination first, first of all, it must rule out several situations that the Ministry of Education stipulates that it is not allowed to transfer, and then "attend the meeting" after the preliminary examination.

        "Attending the meeting" refers to taking the transfer application to the meeting of Hunan University Admissions Leading Group for discussion and voting. The enrollment leading groups are all school leaders, including the president, the vice president in charge of graduate students, the secretary of the school discipline inspection commission and the head of the graduate school.

        Regarding the "cut" left by the Ministry of Education, a number of university graduate students told The Paper that some people have special circumstances and must be considered.

        Regarding the unfairness caused by the transfer of scholars from ordinary universities to key schools, Vice President Liu of the Graduate School of Central South University of Forestry and Technology said that the transfer needs strict examination, so it will not cause large-scale unfairness.

        Many university officials also emphasized to The Paper that the transfer of graduate students is only a small probability event, and very few graduate students transfer every year.

        Even Hunan University, a "big family" of graduate students in Hunan Province, usually transfers in single digits every year, only in 2014, it soared to 17.

Special difficulties or discretionary factors?

        The Ministry of Education’s Regulations on the Management of Students in Colleges and Universities clearly stipulates that students with "special difficulties" can apply for transfer, but it does not specify what "special difficulties" there are.

        Colleges and universities also follow the concept of "special difficulties" of the Ministry of Education when formulating the regulations on student status management, and have not refined it.

        Therefore, in practice, the "special difficulties" put forward by graduate students applying for transfer can be described in various ways.

        She Zuochen, director of the Graduate Department of Jishou University, did not agree with The Paper to consult the application form of graduate students transferred from this school, saying that the materials had been filed and the administrator had taken a holiday.

        He orally introduced the reasons why Liu and Luo, 2013 graduate students who transferred from this school to Hunan University, transferred to other schools.

        Before Liu was admitted to Jishou University as a graduate student, she had studied in Hunan University for two years with master’s degree equivalent, so the school agreed to transfer her. "We consider for the students, after all, Hunan University is higher than our platform"; Luo is because his father who works in Changsha is in poor health and needs to be taken care of.

        She Zuochen said that many transfer graduate students are the only children of single-parent families, and single parents are still sick. "Don’t think about it."

        Yang and Xu, graduate students in 2013, transferred from Hunan University of Science and Technology to Hunan University.

        Yao Jingcheng, deputy dean of the Graduate School of Hunan University of Science and Technology, said that Yang, who was admitted to the fine arts school, was allergic to oil painting, and the school did not have a design major, so she agreed to transfer to the design art school of Hunan University.

        Since I’m allergic to oil painting, why did I apply for a postgraduate degree in fine arts at Hunan University of Science and Technology? The Paper contacted Yang through Weibo’s private letter, but the other party didn’t reply after asking about transfer and oil painting allergy.

        The Paper found that Yang majored in online media art design at Hunan University.

        As for Xu, Yao Jingcheng said that his application for transfer was due to financial difficulties, but did not specify what kind of financial difficulties it was. He only emphasized that Changsha, the provincial capital, had good economic conditions and many opportunities.

        Three 2013 graduate students from Central South University of Forestry and Technology transferred to Hunan University. The graduate school of this school also rejected The Paper’s request to view the application form for graduate transfer, saying that only specialized departments can view students’ archives.

        A teacher at the Graduate School of Central South University of Forestry and Technology said that most of the reasons for students’ transfer were because students found that their interests were inconsistent with the training priorities of the school after entering the school. "If you can’t learn, you will either drop out of school or transfer."

        Tang Zhenming, a spokesman for Hunan University, also pointed out that students have a strong interest in a certain subject of Hunan University, and Hunan University will accept their application for transfer if they find that the other party has potential. He said that graduate students emphasize professional ability more than undergraduates.

        Another situation is that students are not used to transferring the soil, water, diet and so on from the school.

        Wang, a 2013 graduate student who transferred from Jishou University to Hunan University, told The Paper that the reason for the transfer was physical reasons, and he didn’t adapt to the mountainous climate in Jishou.

        The name of Tang Zhen was once transferred from Hunan University to a Hebei graduate student because he couldn’t get used to the spicy Hunan food.

        In practice, some universities will also consider the children of their own schools for transfer.

        In short, the "special difficulties" stipulated by the Ministry of Education have evolved into various reasons in practice. Dean Liu of Central South University of Forestry and Technology summarized that any special circumstances can be applied, and then the school will review the reasons for the application.

        In a sense, the "special difficulties" stipulated by the Ministry of Education have evolved into various discretionary factors in practice.

The opaque transfer process

        Postgraduates who apply for transfer generally have to go through three levels, transfer out of school, transfer to school and the degree office of the provincial education department. If they transfer from other provinces, they have to go through the examination of the education departments of other provinces.

        The internal audit process of the school is also very complicated, which generally requires the signature and consent of the tutor, the college, the graduate school and the leader of the competent school. For example, Hunan University also needs an enrollment leading group composed of many famous school leaders to hold a meeting to discuss and vote.

        After the transfer and transfer to the school are agreed, they will be reported to the Academic Degree Office of the Provincial Department of Education. A staff member of the degree office said that the office is mainly responsible for confirmation and filing. Mainly confirm three contents: whether the universities on both sides agree, whether they are officially admitted students, and whether they are prohibited from transferring to other schools according to the regulations of the Ministry of Education.

        However, there is no provision for publicity in the complicated and well-designed transfer review procedure.

        The Paper searched the official website of Hunan University, but found no information related to transfer, and the transfer situation of 17 2013 graduate students was completely unknown.

        Not only in Hunan University, but also in official website, six universities where 17 graduate students transferred, there is no information about these students’ transfer.

        The Paper asked many graduate students from Changsha University of Science and Technology, Hunan University of Science and Technology, Central South University of Forestry and Technology, and Jishou University, all of whom said that they had never seen the transfer students notified or publicized by the school.

        Several graduate students from Jishou University told The Paper that either the number of students was reduced during the class reunion, or they didn’t show up for a long time, and then they found out that some students had transferred to another school after asking each other.

        In fact, it seems to be a common unspoken rule for all localities to keep the transfer information of graduate students in colleges and universities secret. Searching the keyword "graduate+transfer" casually on the Internet can’t find any public information about transfer students.

        A staff member of the Academic Degree Office of Hunan Provincial Department of Education said that Decree No.21 of the Ministry of Education did not stipulate publicity.

        A person from a university explained that because schools are not willing to transfer their graduate students, they will not promote it.

        However, this kind of internal audit, which is not open to the public, is easy to make people guess. When it comes to transfer, the biggest magic weapon that many people think of is relationship.

        A graduate student of Changsha University of Science and Technology told The Paper that transfer is "all done behind closed doors, not open and fair" and "mainly depends on your relationship".

        Although Hunan University claimed that the transfer procedures of 17 graduate students were in compliance after self-examination, the number of transfer students in this session almost doubled than before, and it was not publicized, which eventually triggered online questioning.

        In January 2014, the Admissions Leading Group of Hunan University held a meeting and decided to accept 17 2013 graduate students to transfer to Hunan University. "The meeting was very heated." In the same month, the group made a new regulation that it would no longer accept the transfer application of master students from non-"985" universities.

        Tang Zhenming, director of the Propaganda Department of Hunan University Party Committee and spokesperson, said that this is because the school leaders want to ensure the quality of graduate students’ "import".

        However, when accepting 17 graduate students from non-"985" universities, after a heated discussion, I immediately made a decision not to accept graduate students from non-"985" universities in the future, and the behind-the-scenes motivation made people think more.

        Even the official of Hunan University does not deny that this decision has the consideration of excluding people from greeting and taking relationships. "I am too lazy to pay attention to you, just set a threshold of’ 985′."

        As a result of the establishment of the threshold, none of the 2014 graduate students entered Hunan University through transfer.  

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How do multiple factors affect apparel enterprises to go against the trend in a difficult situation?

  Reading tips

  Clothing is a sunrise industry that never ends. However, due to the epidemic situation and other factors, the operating efficiency of enterprises is not optimistic. In the predicament, enterprises seize the opportunity of internet plus’s transformation, and promote the rise of "new national fashion clothing" with flow efficiency. The "going out of the circle" of all kinds of characteristic clothing will promote new scenes, new trends and new vitality of consumption and bring new growth momentum to the industry.

  "Food, clothing, housing and transportation", in the shopping list of ordinary people, "clothing" is the first consumption hotspot, and the clothing industry has also become a hot "track" for many cities to compete for layout and pursuit. Recently, Zhiyi Technology, which was established only four years ago, has completed three rounds of financing of nearly 100 million US dollars.

  According to the data of Tianyancha, up to now, there are more than 21 million garment enterprises in China, including 5.235 million newly registered enterprises in 2021, with a growth rate of 39.2%. However, the operating efficiency is not optimistic. Statistics show that from January to May 2022, the total retail sales of clothing, shoes, hats and knitted textiles in China reached 509.3 billion yuan, down 8.1% year-on-year. In May, the total retail sales of clothing, shoes, hats and textiles in a single month was 95.8 billion yuan, down 16.2% year-on-year.

  "Chongqing School" clothing is speeding up the race.

  Clothing is a sunrise industry that never ends. However, the garment industry generally faces the dilemma of scattered production bases and weak brand appeal. The completion of China Textile Clothing City in Chongqing, which is positioned as a "global fashion runway and a new city of clothing industry", has made more than 3,000 garment manufacturing enterprises end the long-term days of renting factories to fight guerrillas. Together with Shangmeng Chongqing Fashion Industrial Park, it has formed a textile clothing industrial base with an annual output value of nearly 100 billion yuan in Banan District of Chongqing, becoming the largest "Fashion Silicon Valley" in the west, integrating clothing creative research and development, production, logistics and commerce.

  "I have invested 100 million yuan in the textile and garment city, which is only a factory building." Mr. Tong, the well-known chairman of a fur garment in Haining, Zhejiang Province, told reporters on July 3 that compared with the coastal areas, the cost of making garments in Chongqing can be reduced by at least about 10%.

  The data shows that there are 169,000 garment enterprises in Chongqing. "Chongqing people are cheerful and inclusive, and it is easier to accept advanced fashion information. Developing the fashion industry has very good software and hardware. " Liang Mingyu, a master of fashion design and a professor of design at the School of Textile and Apparel, Southwest University, said.

  According to him, there are 16 colleges and universities in Chongqing that offer fashion design majors, and the ranks of young fashion designers are also growing year by year, but a large part of them have flowed to other places. The next step is to consider how to retain people.

  The reporter learned from the Talent Training Center of China Textile Clothing City in Chongqing that in recent years, Chongqing garment enterprises have set aside an annual income of nearly one million yuan to seek talents and attract design and management executives. "With the linkage between enterprises and the government, once the brand highland is formed, talents will flow from coastal areas and other places to Chongqing." Chen Mao, general manager of Chongqing Shangxian Human Resources Consulting Co., Ltd. believes.

  "The textile industry is located in the surrounding districts and counties, and the main city focuses on fashion clothing design, research and development and processing." The person in charge of the Consumer Goods Industry Department of Chongqing Economic and Information Committee said that according to the plan of the municipal government, in the future, Chongqing textile clothing will form five major industrial sectors: the main city (Banan), Fuling, the reservoir area, western Chongqing and southeastern Chongqing. Taking the urban fashion clothing industry chain as the leader, each plate has different characteristics, which drives the dislocation development of the whole industry chain from textile to clothing.

  Tang Juncai, head of Shangmeng Chongqing Fashion Industrial Park, told reporters that the industrial park has been committed to integrating domestic and international clothing industry resources and realizing the global allocation of industry resources. At present, the service platform of "Top Grade in Korea" has attracted hundreds of Korean fabric enterprises and excellent fashion designer brands to join.

  Promoting the Rise of "New National Fashion Clothing" with Flow Efficiency

  At present, the "Z generation" represented by the post-90s and post-00s shows a new trend of paying for interest, face value and fashion in clothing consumption.

  This year’s "618", online clothing stores once again felt a burst of madness, while some old casual clothes were experiencing the wave of "shrinking" offline.

  According to the data report of "2022 Tik Tok 618 Good Things Festival" released by Tik Tok E-commerce, with the help of scene construction and topic marketing, Tik Tok E-commerce clothing industry has expanded marketing channels for merchants through diversified gameplay, achieving a breakthrough in promotion and sales. During the "618" Good Things Festival in Tik Tok, GMV in the clothing, shoes and bags industry broke 2,467 million brand merchants, and GMV broke 2,625 million commodities, and the peak number of new customers in the industry increased by 57% from the previous month.

  The reporter found that from Li Ning, Anta, Xtep and other sports brands to the national trend of art and fashion brought by Jiannong and Mark Huafei, an era that belongs to the light of domestic products of clothing is coming.

  According to the financial reports of relevant companies, in 2021, the annual revenue of domestic sportswear brand Li Ning Sports exceeded 20 billion yuan, an increase of 56.1%; The annual revenue of Anta Sports is nearly 50 billion yuan, an increase of 38.9%; Xtep’s annual revenue is 10.013 billion yuan, which is also the first time that it has exceeded the 10 billion mark.

  As an original brand in China, Beijing Jiannong Sporting Goods Co., Ltd., founded in 1994, has been rooted in the clothing industry for 28 years. According to reports, the company has served more than 400,000 government agencies, enterprises, institutions and social organizations, participated in the service of major events such as the 2008 Beijing Olympic Games, and established service centers in more than 300 cities across the country, including Chongqing.

  "We always take promoting China culture and adhering to original design as the foundation, and regard China’s excellent traditional culture as the guiding culture of enterprises, brands and products." Wang Yuming, the founder and chief designer of Jiannong, told reporters a few days ago that "under the epidemic, enterprises have encountered many difficulties, but with this cultural confidence, I believe the difficulties are temporary." With an eye to the future, Jiannong will continue to deepen the field of clothing group buying, and at present, it is carrying out product innovation, combining with intelligent data management and integrating with Internet systematic tools, and striving to make China culture present in people’s field of vision in a vivid form.

  As one of the representative brands of new national fashion, Mark Huafei has always believed in "born for the tide" since its establishment 20 years ago. According to the data of Pinduoduo, among the people who buy Mark Huafei, the post-90s generation accounts for more than 48%, mainly in first-and second-tier cities.

  "Responding to consumer demand with the personality pursuit of integrated culture and catching up with the market rhythm with a broad and efficient e-commerce platform are the only secrets to win the game." Chen Yun, general manager of Mark Huafei’s e-commerce, said that the company’s co-branded clothing with the images of the myth of mountains and seas, China’s auspicious beast and sheep statue, and "timely rain" Song Jiang as the main elements has been sought after by young consumers.

  "The tuyere has been changing, but the market will always lack quality suppliers." Zhang Tianxiang, deputy general manager of Sijiqing Network Company, said in an interview that if you are bent on the R&D and production of offline products, there will naturally be high-quality online channels and Taobao shops who will look for them to place orders, brand and get goods.

  Characteristic clothing may promote the revival of the industry.

  At present, the overall operation of China’s clothing retail industry is steady and slowing down, and it has entered an important period of accelerating the transformation and upgrading of industrial structure. Grasping the transformation opportunity of "internet plus" will bring new growth impetus to the industry. At present, China’s clothing retail industry market has good prospects mainly in sportswear, children’s wear market, high-end women’s wear market and elderly clothing market.

  Zhang Tianxiang told reporters that the Sijiqing clothing market, with women’s wear accounting for more than 90%, has become the rising place of Hangzhou clothing industry. Nowadays, under the "transportation" and gestation of the Four Seasons, the women’s wear industry in Hangzhou is rapidly "out of the circle".

  Wang Weiwei, managing partner of Huaying Capital, pointed out that there are no small opportunities for investment in specific groups and scenes, such as the modern design of traditional cheongsam and the recent hot outdoor brands.

  Forward-looking Industry Research Institute’s "Analysis Report on Market Prospect and Investment Strategy Planning of China Clothing Retail Industry from 2018 to 2023" shows that with the full opening of the birth policy, China’s children’s wear market will maintain a relatively fast growth rate, and it is estimated that by 2023, the children’s wear market will reach 282 billion yuan, with a compound annual growth rate of 10%. In the future, with the economic development and the rapid rise of second, third and fourth tier cities, a broader potential market for high-end women’s wear will be developed, and the market potential of high-end women’s wear is huge.

  "China has become the country with the largest number of elderly people in the world. It is estimated that by 2023, the number of elderly people will further increase, and the elderly clothing market as a blue ocean needs to be further developed. " Mo Yuanming, a researcher at the chongqing technology and business university Chengdu-Chongqing Shuangcheng Economic Circle Collaborative Development Center and the founder of Yuanzhi Smart Library, said that the "going out of the circle" of all kinds of characteristic clothing will promote new consumption scenes, new trends and new vitality, and help to form a newer and more fashionable urban "fireworks atmosphere".

通过admin

China People’s Insurance Company notified the inspection and rectification, and 156 rectification tasks were basically completed.

  People’s Daily Online, Beijing, April 25 (Xinhua) The website of the Supervision Department of the Central Commission for Discipline Inspection today released the Circular of the CPC China PICC Group Committee on Inspection and Rectification. The circular pointed out that in the past two months, the Party Committee of China PICC Group, in the spirit of nailing nails, made every effort to implement various rectification measures item by item against the feedback from the central inspection, and achieved obvious phased results. Up to now, 156 rectification tasks have been basically completed, 195 new rules and regulations have been revised, and 128 people have been held accountable.

  The following is the original text of the notification:

  According to the unified deployment of the central government, from October 30 to December 29, 2015, the 11th Inspection Team of the Central Government conducted a special inspection on China People’s Insurance Group Co., Ltd. (hereinafter referred to as PICC China). On February 1st, 2016, the 11th Inspection Team of the Central Committee gave feedback to the Party Committee of PICC China. According to the relevant provisions of the "Regulations on Patrol Work in the Communist Party of China (CPC)", the patrol rectification situation is now announced.

  First, unify our thinking, strictly follow the facts, and take patrol rectification as a major political task.

  The Party Committee of the Group regards inspection and rectification as an important opportunity to promote the party building and reform and development of the whole group, deeply reflect on problems, condense consensus on rectification, refine rectification measures, strengthen organizational leadership, and solidly promote inspection and rectification work.

  (A) unite ideological consensus and strengthen organizational leadership.

  On February 2, the Group held an enlarged meeting of the Party Committee to thoroughly study and understand the spirit of the important speech delivered by the Supreme Leader General Secretary when he listened to the report on the third round of special inspections in 2015 on January 28, and carefully studied the feedback from the inspections. Everyone agreed that the special inspections conducted by the 11th Inspection Team of the Central Committee on PICC China were accurate, insightful and thorough, which was a comprehensive physical examination of the Party Committee’s management of the party. Through study and discussion, the comrades of the Party Committee formed a "three-point consensus": First, as a strict political patrol, the problems pointed out by the Central Leading Group for Inspection Work are, in the final analysis, that the Party Committee of the Group does not have a deep understanding of the comprehensive and strict management of the Party, and that it is lax in managing the Party, taking the main responsibility and fulfilling the "one post and two responsibilities" is not in place. The rectification work must work hard to give play to the leading core role of the Party Committee of the Group. Second, China PICC Group is a financial enterprise under the central management. It should have high standards and strict requirements in comprehensively and strictly administering the Party, have a sense of "keeping pace", focus on strengthening political awareness, overall awareness and sense of responsibility, and unconditionally rectify the problems pointed out by the inspection without emphasizing objectivity. Third, the key to strictly administering the party in an all-round way is to be strict, and the core is to be governed. The rectification work should dare to expose shortcomings and expose ugliness, dare to dig deep and examine them carefully, and dare to be real and hard. Starting with the rectification of the problems pointed out by the patrol, we will push forward the rectification work of the "2016 Comprehensive Rectification Year", give full play to the positive energy of the patrol work, and promote reform and innovation through patrol rectification.Promote the sustainable and healthy development of the Group.

  The Party Committee of the Group decided to take the inspection and rectification work as a concentrated practice to fulfill "one post and two responsibilities". The Party Committee is the leading organization for inspection and rectification work, and each Party Committee member is mainly responsible for the rectification work in the field in charge. A patrol and rectification coordination group was set up, with Party Secretary Wu Yan as the team leader and Discipline Inspection Commission Secretary Zhuang Chaoying as the deputy team leader, and all subsidiaries also set up corresponding institutions as required. Comrade Wu Yan, secretary of the Party Committee, took the lead in setting an example. He interviewed 45 members of the Party Committee, the head of the headquarters department and the members of the subsidiary party Committee, and talked about how to implement "one post and two responsibilities", enhance party constitution’s awareness, and do a good job in inspection and rectification. Members of the Party Committee earnestly performed "one post and two responsibilities", took their seats accordingly, and held several special meetings of the departments in charge to specifically study the rectification work in the areas in charge. During the inspection and inspection and rectification, the Group held three special democratic life meetings of Party committees, 13 party committees, 10 disciplinary committees and 6 inspection and rectification coordination promotion meetings to study and deploy inspection and rectification work and ensure the orderly progress of inspection and rectification.

  (B) adhere to the problem-oriented and strict process control.

  The Party Committee of the Group detailed and decomposed 30 rectification tasks of the Group headquarters and 126 rectification tasks of eight subsidiaries one by one according to the feedback, forming a "three lists" of problems, tasks and responsibilities. On February 4th, the Party Committee of the Group issued the "Rectification Plan for Feedback from the Party Committee of China People’s Insurance Group on Special Inspection by the 11th Inspection Team of the Central Committee". The Commission for Discipline Inspection of the Group divided and deployed 208 letters and visits handed over by the Central Leading Group for Inspection Work to subsidiaries according to the management authority of cadres, and led by three Party committee members to form three verification teams, which went to the headquarters of relevant subsidiaries to carry out verification work. On March 11th, the Party Committee of the Group issued the Notice on Doing a Good Job in Inspection and Rectification Work again, demanding to thoroughly understand the spirit of inspection feedback and further strengthen the accountability and correction of inspection and rectification work. The patrol rectification coordination group holds regular meetings every week to coordinate and promote various rectification work. The Commission for Discipline Inspection of the Group keeps a close eye on every specific issue and goes all out to do a good job in taking the lead, supervising and coordinating, and checking and handling cases. The Office of the Coordination Group for Inspection and Rectification will follow up and implement the specific problems item by item, compile six issues of Special Inspection and Rectification work briefing, and issue it to the whole system to supervise and guide the inspection and rectification work. For some common problems in the disposal of over-standard vehicles and the verification of letters and visits, the Group defined the standards in a unified way, defined the disposal methods, and put them into practice from the headquarters to the branches, thus ensuring the unified and standardized rectification measures of the whole system and promoting the solid and strict inspection and rectification.

  (3) Pay attention to the analogy and promote both the symptoms and the root causes.

  The patrol rectification work is not only in the right place, but also pays attention to the rectification of problems pointed out by feedback; We also pay attention to digging deep into the root causes and rectifying the crux of the problem. Efforts have been made to grasp the "five combinations": First, the headquarters rectification is combined with the overall promotion of the system. The focus of rectification is on the headquarters of the Group and its subsidiaries, and some specific problems also involve the branches of the system. The Party Committee of the Group has made unified arrangements for the rectification work, linked up and down, and treated both the symptoms and the root causes, forming an overall effect. The second is the combination of highlighting key points and comprehensive rectification. The Party Committee of the Group has designated 2016 as the "year of comprehensive rectification", and comprehensively rectified the problems found by the central inspection, national audit and the "four winds" rectification deployed by the Central Commission for Discipline Inspection. The patrol rectification has established 6 key sectors and 3 key areas. For six key sectors, such as party building and organization personnel, discipline inspection and supervision, "three majors and one big", investment decision-making, agricultural insurance, and "four winds", the work plan was refined respectively to promote systematic rectification; In view of the inspection, it was pointed out that the specific problems involved three key subsidiaries, and supervision and guidance were strengthened. At the same time, the patrol rectification was combined with the audit rectification and the rectification of the "four winds" problem, and a joint coordination meeting was held to make unified arrangements and supervise the rectification. All the 128 rectification tasks pointed out by the national audit were completed, and the "four winds" problem was rectified.Looking back "to complete the self-examination. Drive comprehensive rectification with patrol rectification, and consolidate the results of patrol rectification with comprehensive rectification. The third is to adhere to the combination of correcting specific problems and establishing rules and regulations. While doing a good job in the implementation of 156 inspection and rectification tasks, the Group and the party committees of its subsidiaries formulated 195 revised rules and regulations around party building, "three majors and one big one", selection and employment, and accountability. Fourth, adhere to the combination of case warning education and typical positive propaganda. The Group has successively forwarded three batches of 38 typical cases issued by the Central Commission for Discipline Inspection, made the first batch of centralized notification on 24 typical cases investigated and dealt with by this system that violated the spirit of the eight central regulations and organizational discipline, and made the second batch of centralized notification on 8 typical cases investigated and dealt with recently. At the same time, pay attention to the leading role of positive models, and set up two models: the Party Committee of PICC P&C Zhejiang Branch strengthens the main responsibility and the Disciplinary Committee of Hunan Branch strengthens the supervision responsibility, which provides a benchmark for the implementation and rectification of the "two responsibility" in the whole system. Fifth, adhere to the combination of surface rectification and extension and deepening. In accordance with the principle that everything is settled and everything is echoed, while completing the "specified tasks" of patrol rectification, we should pay attention to forcing reform through rectification, intensify the integration construction of the Group, promote product, service and management innovation, and promote the extension and deepening of patrol rectification.

  Second, focus on the problem, treat both the symptoms and the root causes, and do our best to rectify the feedback from the central inspection.

  In the past two months, in the spirit of nailing, the Party Committee of China PICC Group has made every effort to implement various rectification measures by comparing the feedback from the central inspection item by item, and achieved obvious phased results. Up to now, 156 rectification tasks have been basically completed, 195 new rules and regulations have been revised, and 128 people have been held accountable.

  (a) on strengthening the core role of the Party Committee, the implementation of the main responsibility of the rectification.

  The Party Committee of PICC Group insists on the rectification work, first of all, we must grasp the core essence of managing the party and the party, shoulder the "hard task" of managing the party and the party, and strive to strengthen the core role of the party Committee’s leadership.

  1. Strictly implement the main responsibility. In view of the problem that the core role of party Committee leadership is not fully played, the party Committee of the group strengthens the implementation of "one post and two responsibilities", compacts the responsibilities at different levels, and strictly pursues the responsibility for the ineffective party building work. First, the party Committee team itself improves its ideological understanding. The Party Committee of the Group focused on the requirements of the central government’s political inspection, made every effort to do a good job in rectification, and the members of the team took their seats to inspect the rectification issues, and held three special democratic life meetings to carry out criticism and self-criticism. The members of the Party Committee insist on putting themselves in, putting their work responsibilities in, and taking the initiative to take responsibility. Second, for the first time, the party Committee of the subsidiary was seriously accountable. On March 24th, the Party Committee of the Group held an enlarged meeting to listen to the review of the party committees of subsidiaries with more problems in the patrol feedback. Three insurance subsidiaries, PICC P&C Insurance, PICC Health Insurance and PICC Life Insurance, deeply reflected on the outstanding problems pointed out by the patrol feedback, such as lax compliance with political discipline, lack of "three majors and one big" system, weakening of grass-roots party organizations, and irregular decision-making procedures for major investments, and made an analysis and inspection. The Party Committee of the Group approved the whole system, educating and alerting party organizations at all levels and leading cadres in party member to truly shoulder the responsibility of managing the party and the party. The third is to carry out the review of party building. The Group has formulated the "Implementation Measures for the Evaluation and Assessment of Party Committee Secretaries of Group Companies Grasping Grassroots Party Building Work", which links the assessment results with the comprehensive assessment and evaluation of party committees and party secretaries, and emphasizes the responsibility of "the first responsible person".Every year, the members of the Party Committee team should report to the Party Committee at the corresponding level on the work of grasping business and party building, and bask in the report card of "one post and two responsibilities". The Party Committee of the Group organized a debriefing evaluation on the work of Party secretaries of eight subsidiaries and executive deputy secretaries of government party committees at the grass-roots level, and listened to the debriefing of party construction of subsidiaries. The Party Committee of the Group organized a debriefing evaluation on the work of the secretary of the Party branch (general party branch) of the headquarters department of the Group. The evaluation results were included in the year-end performance appraisal. The fourth is to sign the responsibility certificate step by step. In accordance with the spirit of the Group’s Guiding Opinions on Implementing the Main Responsibility of Building a Clean and Honest Party Style, the content of the responsibility of strictly administering the Party was enriched and improved. The Party Committee Secretary of the Group and the Party Committee Secretaries of eight subsidiaries signed the Responsibility Certificate for Strictly Administering the Party in an All-round Way, which was systematically decomposed layer by layer, and a total of 5,014 main responsibility certificates were signed. The implementation of "two responsibility" will be included in the Group’s key work in 2016, and the party building work will be included in the 2016 key performance indicators assessment system for the principal responsible persons of subsidiaries.

  2. Improve grassroots party organizations. The Party Committee of the Group has made great efforts to solve the problem that the Party’s leadership lacks organizational support at the grassroots level, and strived to lay a solid foundation for Party building at the grassroots level. First, complete and improve the party committees of provincial branches. In view of the imperfection of some provincial-level institutions of PICC Life Insurance and PICC Health Insurance, in 2015, the Group selected 25 PICC P&C cadres to exchange with PICC Life Insurance and PICC Health Insurance. Nine provincial-level institutions with fewer members of PICC Life Insurance have all been equipped in place; People’s Insurance Company of China (PICC) still lacks a member of the Party Committee in Guangdong and Dalian branches, and is currently in communication and planning to exchange candidates. The second is to promote the full coverage of party organizations at the grassroots level. In view of the large number of branches in districts and counties and the imperfect party organizations, the Interim Provisions on the Construction of Joint Party Branches have been formulated to strengthen the effective coverage of party organizations in four-level institutions through the establishment of joint party branches. At present, the whole system should set up 1490 joint party branches, of which 1432 have been set up and 58 are being set up, and the coverage rate of established joint party branches reaches 96.11%. Organize the development and application of the "Party Building Cloud" platform to build an online community for party member, party workers, grassroots party branches and grassroots party committees to work, learn and communicate. Third, precisely regulate the development of grassroots party member. The Group issued the Notice on Regulating party member’s Development Structure and Perfecting Grassroots Party Organizations, requiring branches at all levels to implement targeted regulation and control on party member’s development, and increase efforts to develop party member in key positions.In 2016 and 2017, we will focus on the development of party member in municipal, district and county institutions, so as to realize the wide coverage of district and county institutions by Party organizations. The fourth is to formulate plans for the construction of grass-roots party organizations. The Group has formulated the "China People’s Insurance Group’s 2016-2018 Plan for Strictly Strengthening the Construction of Grass-roots Party Organizations", which systematically solves the outstanding problems in the construction of grass-roots party organizations from the aspects of improving ideological understanding, improving organizational support, strengthening system construction, strengthening the implementation of responsibilities, and strict assessment and supervision. It is clear that in 2018, the establishment of party committees in prefecture-level institutions will reach 100%, and the establishment of party branches in district and county institutions will reach more than 50%; It is required that 175 prefecture-level institutions with imperfect party committees of PICC Life Insurance should be fully equipped before the end of September 2016, and provincial, prefecture-level branches should study and formulate the working rules of party organizations at the corresponding level before the end of June 2016.

  3. Fully implement the "three majors and one big" decision-making system. The Party Committee of the Group strictly implements the system of "three majors and one big" in the whole system, and strengthens political discipline and rules. The first is to seriously rectify outstanding problems. In view of the problem that PICC P&C Subsidiary failed to issue and implement the Group’s implementation measures on the "three majors and one big" decision-making system in time, the Party Committee of PICC P&C Subsidiary was instructed to reflect deeply. The Party Committee of the company made a review and serious rectification, revised the Decision-making Measures of the Party Committee for Further Implementing the System of "Three Heavies and One Big", the Amount Standard of the Decision-making Items of the Party Committee and the Explanation of the Core Elements of the Meeting of the Party Committee, and further refined the scope standards, decision-making procedures, implementation requirements and supervision and accountability of the "Three Heavies and One Big". Revised the Manual of Power and Responsibility Norms (2016 edition) to further improve the relationship between collective decision-making and authorization management. In view of the problem that the top leaders of some provincial branches are not strict and standardized in complying with the relevant systems of "three majors and one big", the relevant subsidiaries are required to rectify within a time limit. PICC Life Insurance Company has revised the Implementation Measures for the "Triple and Big" Decision of the Party Committee of the Head Office and the Party Committee of the Provincial Branch.The "Measures for the Implementation of the" Three Heavy and One Big "Decision-making" has trained the party committee secretaries at provincial and prefecture levels in the "three heavy and one big" decision-making system and the scope of discussion, added the "three heavy and one big" decision-making information filing module of provincial branches in the OA system, and uploaded the meeting minutes of party committees as the daily management and off-site supervision platform of the head office to promote the standardized operation of the "three heavy and one big" decision-making matters of branches. The second is to continue to rectify universal problems. Before the inspection, the Party Committee of the Group organized all subsidiaries to conduct a comprehensive self-inspection of the implementation of the "three majors and one big" decision-making system. Members of the Party Committee of the Group led eight working groups to conduct spot checks on 22 provincial branches, and found 130 problems in the implementation of the "three majors and one big" decision-making system, put forward 51 rectification opinions, and the provincial branches formulated 206 rectification measures. During the inspection and rectification, focusing on the common problems found in self-inspection and spot checks, the Group continued to follow up and supervise the implementation of rectification in three aspects: system construction, implementation of basic procedures, supervision and accountability, and severely dealt with and notified those who violated discipline.

  4. Make overall plans to promote party building. The Party Committee of the Group firmly established the concept of "doing a good job in Party building is the greatest achievement" and enhanced the consciousness of implementing the main responsibility of strictly administering the Party in an all-round way. First, clearly and regularly study the party building work system. The Party Committee clearly holds a special meeting of the Party Committee at least once a month to study the party building work, and requires the party committees of all subsidiaries to establish a system of special research on the party building work. Party committee secretaries at all levels teach party classes at least once a year. The second is to comprehensively coordinate the party building work. Incorporate the party building work into the Outline of the Group’s "Thirteenth Five-Year Development Plan", and comprehensively coordinate the party building work from four aspects: strengthening the implementation of "one post and two responsibilities", improving the organizational system, institutional system and supervision and evaluation system of party building work. The third is to carry out the education of strictly administering the party. Grasp the learning system of the Central Committee of the Party Committee, formulate and implement the "Learning Plan for the Central Committee of the Party Committee of the Group in 2016", and deploy and study the spirit of the previous central meetings since the 18 th National Congress of the Communist Party of China and the spirit of the series of speeches by the General Secretary of the Supreme Leader. Grasping the backbone education, 460 people, including the group headquarters, members of the party committees of subsidiaries, and discipline inspection cadres of provincial branches, have been organized to conduct centralized training on party building and discipline inspection and supervision in enterprises. Grasp the education in party member, plan and promote the "two studies and one work" study and education, and promote the comprehensive and strict management of the party to the grassroots. Grasping the discipline education of employees, the Commission for Discipline Inspection of the Group has formulated the "Red Line Manual for Integrity", which defines the "red line" in nine aspects.On this basis, guide all subsidiaries to formulate the company’s "red line manual", form a "1+N" series of teaching materials, and carry out discipline education for all employees.

  (two) strict rules and procedures, standardize the rectification of the organization and personnel work.

  On February 23, 2016, the Party Committee of the Group organized a meeting on personnel rectification of the Group, focusing on the whole process of selecting and employing people.

  1 resolutely investigate and deal with illegal employment problems, and seriously organize personnel work discipline. Comprehensive verification, resolutely correct and correct, and seriously investigate the responsibility of relevant personnel. Dismissal and re-arrangement of two relatives of the head of the branch who were promoted in violation of regulations; The labor contract was terminated for one relative transferred in violation of regulations, and one person was reassigned; Of the 19 cadres who were promoted in violation of regulations, one who did not meet the requirements has been dismissed, and the remaining 18 have been evaluated democratically, and will put forward treatment opinions in combination with performance appraisal; Serious accountability was given to those responsible for the appointment and dismissal of cadres by online office countersignature without the study of the party Committee; Of the two cadres who were "promoted with illness", one was given a serious warning and administrative dismissal within the party, and the other was cancelled; Administrative dismissal of one person whose original treatment was not in place. Those responsible for employing people in violation of regulations were investigated for responsibility, and 4 people were given disciplinary sanctions by the party and government.

  2. Standardize the procedures for selecting and employing people and broaden the channels for selecting and employing people. From the first step of selecting and employing people, the Group formulated and promulgated the Detailed Rules for the Brewing of the Proposal for Selecting and Appointing Cadres to standardize the brewing process of the proposal for selecting and appointing cadres and the recommendation motion behavior of leading cadres, especially the "top leaders"; Broaden the horizons of selecting and employing people, formulate and implement the "Implementation Measures for Competitive Posts for Managers in Group Headquarters", and pay attention to selecting and transferring cadres from the grassroots level; The Interim Measures for Employees’ Post Training was issued, and the two-way exchange between the headquarters and subsidiaries of the Group was continued. By improving the openness and transparency of the selection and employment of personnel at the headquarters, the guiding role under the above rate was brought into play.

  3. Strengthen the management of the selection and employment process, and put an end to the phenomenon of "illegal promotion or even promotion of cadres despite illness". Issued the "Detailed Rules for the Implementation of the Request for Filing of the Selection and Appointment of Leaders of Subsidiaries", which made more detailed audit requirements for leapfrog promotion and exceptional promotion; The "Documentary Essentials of Cadre Selection and Appointment" was formulated, and the qualification conditions, nomination brewing, recommendation, inspection, research decision, publicity, appointment and dismissal of cadres were recorded in the whole process; The detailed rules for the implementation of pre-appointment talks for newly promoted cadres were issued by the group headquarters to strengthen the propaganda of cadre education and supervision policies.

  4. Improve the cadre supervision system and strengthen the supervision of selecting and employing people. The headquarters of the Group has set up a separate cadre supervision office, each subsidiary has set up a cadre supervision office separately or jointly, and the provincial organizations and personnel departments of the three major insurance subsidiaries have set up cadre supervision posts. Deepen the implementation of the Group’s Guiding Opinions on Strengthening the Supervision of Cadres, and urge major subsidiaries to formulate the Implementation Measures for the Supervision of the Selection and Appointment of Cadres. The "Ten Must-Check Notice" was issued to clarify the necessary checks and checks in the selection and appointment procedures of cadres, so as to prevent "promotion with illness" and "taking up posts with illness". The Special Inspection Measures for the Selection and Employment of Subsidiaries and the Detailed Rules for the Implementation of "One Report and Two Comments" for the Selection and Employment of Subsidiaries were issued to strengthen the penetrating inspection of the selection and employment of institutions at all levels of the system and strengthen the supervision of the selection and employment.

  5. Strictly implement the reporting system for personal matters, in order to solve the problem of "‘ Everything must be nuclear ’ The implementation is not strict. The Group issued the Notice on Doing a Good Job in Reporting Personal Matters by Leading Cadres in 2016, clarifying that the scope of reporting personal matters is extended to the heads of the headquarters departments of the Group and subsidiaries, the heads of the headquarters departments of provincial institutions, and the personnel above the members of the municipal institutions; Complete the configuration of the report system software and the input and summary equipment of the institutions above the provincial level; Formulated the "Detailed Rules for the Implementation of the Group’s" All Mention Must Be Checked "to standardize the whole system’s" All Mention Must Be Checked "work. During the inspection, two leading cadres of branches who failed to report personal matters as required were dismissed and dismissed respectively, and were notified on the website of the Supervision Department of the Central Commission for Discipline Inspection. For the problem that the heads of the headquarters departments of provincial institutions and the members of the municipal institutions failed to "check everything before promotion", the relevant subsidiaries were instructed to carry out supplementary verification of personal matters. In March, the supplementary verification information of personal matters of all 1,552 people was reported to the Cadre Supervision Bureau of the Central Organization Department.

  6. Implement the work of "defining departmental responsibilities, internal organs and staffing" and solve the problem of "overstaffed cadres". Before the end of June, 2016, formulate the Human Resources Plan for the Group Headquarters, revise the Measures for the Management of Sequential Personnel and the Measures for the Management of Professional Sequential Personnel, and clarify the positions of heads of departments and offices at the headquarters. At present, 24 of the 47 cadres who have been checked out by themselves have been digested, and 14 departmental management posts of 7 provincial-level institutions and 9 team members of 4 prefecture-level institutions have not been adjusted. In March 2016, PICC P&C issued a "military order" that was digested before the end of the year. The Notice on Strictly Managing the Positions of Leaders in Subsidiaries was issued, urging subsidiaries to carry out the "three-fixed" work, and requiring subsidiaries with company-level executives to issue the "Regulations on the Management of Senior Management Positions" before the end of April 2016, so as to plug the loopholes in arbitrarily setting job names and company-level executives from the source.

  7. Carry out special work to solve the problem of "rampant nepotism". The headquarters of the Group has been expanded everywhere to find out the position of relatives of leading cadres in the system. According to the unified deployment of the Group, PICC P&C has carried out the second round of thorough investigation, and investigated 233 cases that need to be avoided, and rectified the cases that should be avoided within a time limit; PICC Life Insurance has completely rectified 52 people who violated the avoidance of relatives; Other subsidiaries have also earnestly implemented the rectification requirements. Taking the headquarters of the Group as a pilot, we will establish a commitment mechanism for avoiding employment in recruitment, verify the employment status of close relatives in the system in the process of comprehensively promoting recruitment in the Group, and refuse to hire those who should be avoided, so as to prevent nepotism from the source.

  8. Improve the system and mechanism, and plug the management loopholes of "lax implementation of retirement policies", "spamming subsidies", "going abroad illegally for private reasons (territory) and going abroad without approval". The regulations on the dismissal and retirement of people who have reached the age have been strictly defined, and the rectification plan for the problem that the members of the PICC P&C insurance team have not retired has been formulated and is being implemented. The Notice on Strengthening the Management of Total Wages was issued, which standardized the channels for paying salaries and strictly implemented the provisions on deferred payment of salaries. Improve the Interim Measures for Welfare Management of Group Companies and strengthen the welfare management of the group. Revised the Group’s Interim Measures for the Administration of Going Abroad for Private Purposes, and further tightened the management of certificates for going abroad, examination and approval authority and procedures, and accountability. The verification mechanism for accepting and reporting cases of letters and visits by selecting and employing people was further improved, and 8 cases were verified in March, exceeding the number in previous years.

  (3) Rectification of strict rules and regulations and strengthening supervision and accountability.

  The Party Committee of the Group fully supports the work of the Commission for Discipline Inspection, improves the organizational system of discipline inspection and supervision, strictly and promptly investigates and deals with violations of discipline according to discipline, and resolutely stands up discipline and rules.

  1. Focus on disciplinary review to form a deterrent. The Party Committee of the Group attaches great importance to the problem clues assigned by the Central Leading Group for Inspection Work and letters and visits from the masses. The Secretary of the Party Committee personally supervises, and the Secretary of the Discipline Inspection Commission directs, uniformly deploys personnel, and concentrates on disciplinary review, strengthening discipline and establishing rules. During the inspection, the Group seriously investigated and dealt with 32 clues, of which 24 were assigned by the Central Inspection Team and 8 were self-inspected. It also dealt with 75 people who violated the rules and went abroad for private reasons. A total of 133 person-times were investigated for responsibility, of which 23 were punished by Party discipline, 10 by political discipline and 100 by organization. The broad masses of cadres and employees of the group responded strongly and played a deterrent role. During the rectification period, the accountability for discipline has not diminished, and the scale is not loose. We will continue to be strict and realistic, and consolidate the results of inspection and rectification. A total of 2 batches of 208 letters and visits handed over by the Central Inspection Team were verified. Among them, the Commission for Discipline Inspection of the Group organized 14 letters and visits by itself, and the rotor company handled 194 letters and visits. At present, the initial verification of all the letters and visits has been completed. In view of the verified problems, there are 128 persons who violate the rules and regulations (34 disciplinary actions, 34 disciplinary actions, and 60 organizational handling and criticism and education), involving 26 group management cadres or employees of the group headquarters. Among them, there are 14 clues about mental problems that violate the eight central regulations, and 30 people who violate the rules and regulations have been dealt with and entered the processing procedure (17 disciplinary actions, 2 disciplinary actions, and 11 organizational handling and criticism and education);There are 3 clues about violations of political discipline that have been verified, and 3 people who have been dealt with and entered the handling procedures (1 person was disciplined by the party and 2 people were organized to deal with it).

  2. Deepen the rectification of the four winds issue. First, seriously carry out the "four winds" rectification and "look back". We comprehensively sorted out the "four winds" problem and its rectification found by the feedback from the central inspection, the party’s mass line education practice activities, the "three strictness and three realities" special education activities, the feedback from the Commission for Discipline Inspection to the party committees at the same level, and the clues of letters and visits, and formed a list of rectification problems step by step, so that all the items were settled. The "four winds" problem fed back by the Central Leading Group for Inspection Work has been decomposed and implemented 161 times in the system (including the data of rectification and implementation of the same problem in different subsidiaries and institutions at different levels, the same below), and 136 times have been rectified; 6,193 other "four winds" problems found and rectified, 5,182 have been rectified, 1,010 are being rectified, and 1 listed plan has not been rectified; The Central Leading Group for Inspection Work assigned 62 clues to the "four winds" problem, 61 of which have been completed and 1 is being rectified; 112 other clues involving the "four winds" issue have been completed; The Group and its subsidiaries took the lead in carrying out 13 special rectification activities on "four winds". The second is to standardize salary and benefits. Regarding the problem of illegal and over-standard payment of salaries and expenses under various pretexts,Instruct the parties to return the payment, and thus strictly enforce the rigid provisions and disciplinary requirements of salary and welfare. In strict accordance with the Ministry of Finance’s "Administrative Measures for the Audit of the Remuneration of Heads of Central Financial Enterprises", we will fully recover the salaries that three leading cadres have received in violation of regulations. According to the requirements of the Group, all subsidiaries shall comprehensively clean up the subsidized projects in Tianjin, and stop issuing benefits such as meal allowance, communication fee and holiday fee; Completely stop insuring for "small groups" at ultra-low rates, and the premium rate in the later period is in line with the market price level, and the previous premium has been paid back, and personal income tax has been paid back gradually; Strictly dispose of vehicles that exceed the standard. After the release of the eight central regulations, the whole system purchased 73 official vehicles that exceed the standard. Through the evaluation of professional institutions, 56 vehicles have been publicly auctioned, and other vehicles are being processed; Further improve the business management system, improve the management regulations of brokerage agency business, standardize the avoidance of relatives of leading cadres in business operations, and resolutely put an end to nepotism and related transactions. The third is the outstanding problem of special rectification. Comprehensively self-examine the problem of going abroad (abroad) illegally, and ask 75 leading cadres involved to make a review at the democratic life meeting and informed criticism. Two people were dismissed from their posts in the Party, three were given warnings in the Party, two were given administrative warnings, one was removed from his post and restricted from leaving the country for one year, four were restricted from leaving the country for one year, 24 were admonished, two were given warnings in the Party and one was removed from his post. Revise and improve the Interim Measures for the Administration of Group Going Abroad for Private Purposes, and will go abroad.The centralized management of certificates has been expanded from department level to all levels, and the approval module for going abroad for personal reasons has been added to the office system to standardize the approval process. The whole system has centralized management of 3058 certificates for going abroad for personal reasons.

  3. Strong governance of illegal business problems. In view of the illegal business problems such as false intermediary, false expenses, false underwriting of agricultural insurance and claims settlement, we will increase accountability. The first is to comprehensively start the rectification of agricultural insurance problems. For 67 judicial cases of agricultural insurance that occurred since 2013, we will strengthen the accountability and correction of relevant responsible personnel. Of the 76 people involved in the case who have been concluded by the judicial organs, 59 have been held accountable, including 19 disciplinary actions, 37 disciplinary actions and 22 organizational actions. For the false claim of planting insurance of a company in Henan Province in 2013, the relevant personnel were investigated step by step, and a total of 13 people were held accountable. On February 26th, 2016, the Group held the 10th system-wide rural insurance work conference to implement the spirit of Document No.1 of the Central Committee, requiring the whole system to treat the rural insurance from the perspective of serving the transformation of government functions, innovating social governance and people’s livelihood, and to continuously expand the rural insurance with new measures such as improving management and control mode, strengthening platform construction and improving service and support capabilities. PICC P&C was instructed to formulate the Inspection and Rectification Plan of the Agricultural Insurance Division, and issued the Notice on Implementing the Feedback from the Central Inspection to Carry out Agricultural Insurance Rectification in an All-round Way, so as to carry out agricultural insurance rectification in a comprehensive, systematic and in-depth manner, implement the whole process business management of agricultural insurance, realize the close interaction and risk balance between agricultural insurance underwriting and claims, and effectively control the behavior of false underwriting and claims. Second, in-depth rectification in the fields of intermediary management and expense management. Up to now, the amount of false intermediaries has been rectified by measures such as account adjustment and fund recovery, totaling 140 million yuan;Through measures such as increasing the taxable income of enterprise income tax, recovering funds, and paying back personal income tax, the amount of fictitious expenses has been rectified by 480 million yuan. And further improve the long-term rectification measures: in strengthening expense management, formulate a standardized financial system for expenses, optimize various expense allocation systems, and improve the salary quota allocation model; In terms of strictly controlling the withdrawal of funds through fictitious intermediary business, we should improve the internal control system of intermediary business management, seriously examine and manage the intermediary qualification access, and strictly monitor and inspect the intermediary business process. The third is to focus on strengthening the special governance of violations of laws and regulations by grassroots branches. On March 3rd, the Group held a kick-off meeting on the construction of internal control system for branches at the prefecture, county and district levels, and implemented the framework model of internal control system in all institutions at the prefecture, county and district levels of three insurance companies. Grass-roots internal control model will bring integrity risk into the control scope, and accelerate the construction of a strict and standardized operation control system for processes including people, finance and materials. By improving the control system and strengthening accountability, the problem of frequent cases in grass-roots branches can be solved.

  4. Strengthen the construction of discipline inspection and supervision organization system. Implement the regulations of party constitution, return to the responsibility of discipline inspection and supervision, effectively promote the work of "three changes" and build a discipline inspection and supervision team with iron discipline. The first is to improve the discipline inspection and supervision organization. In February, 2016, the Supervision and Audit Department of the Group was formally set up and operated independently, which increased the number of offices and establishments in the discipline inspection and supervision department. Instructed the headquarters of six major subsidiaries to set up independent supervision departments, and the setting work was basically in place. It is explicitly required that qualified provincial branches independently set up discipline inspection and supervision departments, and all provincial branches of insurance subsidiaries are equipped with full-time discipline inspection and supervision cadres. Since the inspection, the system has added 52 full-time supervisors. The second is to increase the clean-up efforts of the secretary of the Disciplinary Committee. At present, the secretary of the Disciplinary Committee of the Group, subsidiaries and provincial branches all quit from the responsibilities related to people, finance and materials, and only take charge of the functional departments related to supervision, such as discipline inspection and supervision, auditing, compliance and risk management, and focus on the main business of supervision, discipline and accountability. For provincial branches with too few team members and it is difficult to form a separation of powers when the secretary of the Disciplinary Committee withdraws from business management, the relevant subsidiaries have been instructed to formulate a work plan for the staffing of provincial institutions and adjusting the division of work of the secretary of the Disciplinary Committee to solve the problem within a time limit. The Group’s 2016 discipline inspection and supervision meeting has clearly put forward targeted measures and requirements for the problem of insufficient discipline inspection and supervision power of prefecture-level institutions. Up to now, PICC P&C Insurance, PICC Health Insurance and PICC Life Insurance have formulated specific plans for the staffing of local branches and the division of labor among disciplinary committee secretaries and submitted them to the Group Disciplinary Committee.According to the documents issued by the Party Committee and the Commission for Discipline Inspection of the Group, the whole system is establishing and improving the evaluation mechanism for the secretary of the Commission for Discipline Inspection, which is mainly based on the higher-level Commission for Discipline Inspection and the organization of personnel departments. The third is to improve the ability of supervision and discipline. The Group has issued the Manual of Integrity Education in the Whole Process of Hierarchical Classification, which distinguishes different levels and posts, and defines the key contents, methods and frequencies of integrity education. The Commission for Discipline Inspection of the Group organized and wrote five practical courseware, such as "Discipline Inspection", "Letters and Visits Check" and "Integrity Risk Prevention and Control", which were distributed to the whole system for training. Before February 21, the first batch of training for disciplinary Committee secretaries and discipline inspection and supervision backbones of institutions above the provincial level was completed. During the inspection and rectification, the Commission for Discipline Inspection of the Group established a collective research system for problem clue handling and disciplinary review, which provided a basis for the problem clue handling of the Group and its subsidiaries and further standardized the problem clue handling. The Commission for Discipline Inspection of the Group regularly organizes the departments of audit, compliance, risk management and investment, finance and business development to communicate information, and feeds back the management problems found by the discipline inspection and supervision departments to the relevant functional departments to build a collaborative supervision mechanism.

  5. Strengthen grasping early and grasping small. Revise and issue the Regulations on Inspection Work of PICC China Group, and formulate the Group’s Inspection Work Plan for 2016. On the basis of full coverage of subsidiaries’ inspections, focus on key matters and key people, and carry out special inspections for provincial branches with many problems, so as to play the role of the sword of inspections and promote the comprehensive and strict management of the party to the grassroots. The Group has formulated and promulgated the Interim Provisions on Standardizing the Handling of Reminding Conversations, Admonishing Conversations and Letters and Inquiries, which will institutionalize and normalize early grasping and small grasping. In the disciplinary review, the system of "double investigation of one case" was strengthened, focusing on "one post and two responsibilities" to carry out "double investigation of one case", highlighting accountability, and forcing leading cadres in party member to assume the main responsibility of building a clean and honest party style. People’s Insurance Company of China held a special party committee to deeply reflect on the problem of poor reporting and handling measures of Hebei and Liaoning branches, and made an in-depth analysis of this problem as a typical example of the party committee’s failure to perform its duties as the main responsibility. The party committee of People’s Insurance Company of China specially reported the inspection report to the party committee of the group. During the inspection and rectification period, a total of five people were investigated by party discipline and political discipline because their main responsibilities and supervisory responsibilities were not in place. The secretary of the Party Committee of the Group directly interviewed the secretary of the Disciplinary Committee of a subsidiary that approved the report letter to the reporter. In order to deal with one education, a major case notification system has been established. Since the central inspection, institutions at all levels of the system have carried out various warning education for 261 times, covering more than 270,000 cadres and employees.

  (four) on strengthening the awareness of reform and promoting the development of rectification.

  Focusing on the key tasks such as implementing the central decision-making and deployment, implementing the overall strategy of the Group, and integrating internal resources, the Party Committee of the Group exerts the positive energy brought by the central inspection, forcing reform and improving the management level of the Group.

  1 resolutely implement the central decision-making and deployment, and actively fulfill political, economic and social responsibilities. The Party Committee of the Group further improved its political acumen, insisted on positioning the insurance and investment business from the height of stressing politics and taking care of the overall situation, and consciously fulfilled its social responsibilities. First, implement the party’s policy of strengthening agriculture, benefiting farmers and enriching farmers. PICC P&C is required to take the reform of the Agricultural Insurance Division as the starting point, improve the business model and management model, and carry out in-depth rectification of agricultural insurance. Increase the development of aquaculture insurance business, and turn it into a profit-oriented development value-oriented one. Improve the compensation ability of agricultural insurance products, and reduce the starting point of compensation for drought and pest losses from 70% to 30% in 2015 to ensure that more farmers can get insurance compensation after the disaster. Focusing on the implementation of the State Council’s opinions on promoting health service industry and accelerating the development of modern insurance service industry, we will actively develop long-term care insurance products and cooperate in the pilot project in Haidian District, Beijing to provide long-term care guarantee for disabled people; Actively develop rural inclusive insurance products, and successively launched 18 micro-insurance products, forming a relatively complete rural micro-insurance product system; Launched the sales of insurance products for a better life in Dalian pension community, and further explored the mode of combining pension community with insurance products; In view of the national health insurance personal tax preferential policy, actively participate in the personal tax preferential health insurance pilot, develop personal tax preferential health insurance products, and take the lead in launching in the whole industry; Focusing on the scientific and technological innovation of insurance services, we will increase the development of scientific and technological insurance products and gradually establish a sound scientific and technological insurance system.The Group is formulating the Supervision System on Implementing the Central Economic Work Principles and Policies, which will implement a series of important arrangements made by the CPC Central Committee, the State Council and the industry supervision departments on insurance to support economic and social development, and will be incorporated into the Group’s business supervision system for subsidiaries, which will be supervised on a monthly basis. Second, the Party Committee of the Group strengthens the organization and leadership of medium and long-term planning. The Group set up a leading group headed by the Party Secretary and attended by other team members, initiated the preparation of the Group’s 13th Five-Year Plan, and strengthened the Party Committee’s research and decision-making on the Group’s overall, long-term and fundamental major issues. We established and implemented the annual business plan and key work arrangement system, issued the 2016 Key Work Arrangement Table, and established 109 annual key work items in 7 categories of the Group, which transformed the major strategy and deployment of the Party Committee of the Group into concrete measures. Third, the Party Committee of the Group strengthened its duties and responsibilities. Resolutely implement the central government’s decision-making and deployment, and study and introduce relevant measures around key areas of economy, society and people’s livelihood, such as serving agriculture, rural areas and farmers, catastrophe protection, social governance, and medical security: building a more professional, open and effective insurance platform for agriculture, rural areas and farmers, vigorously developing rural inclusive finance, and extending rural insurance service chain and value chain; Continue to promote the pilot project of catastrophe insurance and supplement and improve the disaster relief system; Actively develop comprehensive public security, medical liability insurance, food safety liability insurance, environmental pollution liability insurance and other types of insurance related to the national economy and people’s livelihood to better protect and improve people’s livelihood; Set up a social medical insurance center from top to bottom, and establish and improve the franchise mechanism. Adhere to the problem orientation,Study and promote the pilot project of housing reverse mortgage pension insurance. Actively explore the old-age insurance security model combining medical care with nursing care, and build a healthy old-age industrial chain model with people’s insurance characteristics.

  2. Strengthen internal control and promote the integration of the Group. The Party Committee of the Group seized the bull’s nose of strategic management and control, led the integration construction of the whole group, and made efforts to solve the problems such as "the management chain of the Group is too long, the management and control power is poor, the resource integration is not in place, and the core competitiveness is not strong". First, strengthen the organic connection between the group strategy and the subsidiary strategy. Organize all subsidiaries to formulate and improve their own strategies according to the Group’s 13th Five-Year Plan, so as to ensure that the goals of the whole group are consistent and mutually supportive, and avoid the disconnection between the upper and lower levels and the out-of-control strategy. Promote the relevant functional departments of the Group to prepare functional plans such as human resources, capital management, business development, strategic asset allocation, information construction, brand building and risk management, refine the action plan, and realize the organic combination of the overall planning and special functional planning of the Group. Prepare a three-year rolling plan and adjust the medium and long-term strategy in a timely manner. Conduct a strategic implementation evaluation once a year, and instruct all subsidiaries and relevant functional departments to submit planning implementation evaluation reports on an annual basis, and rectify problems in time to ensure that the development of each business unit is always consistent with the strategic direction of the Group. The second is to promote the resource integration of the Group with the construction of four platforms as the starting point. Firmly and steadily promote integration, focus on organizing and coordinating the "four platforms" projects of unified big data platform, unified customer sharing platform, unified e-commerce platform and unified health management platform, start the formulation of unified security policy, promote mobile internet projects, and unify incremental and integrated stocks.Comprehensively improve the level of information sharing and centralized management and control of the Group. The Management Measures for the Group’s Unified Information Security Strategy was formulated and issued. The infrastructure of the Group’s unified big data platform and the Group’s unified customer sharing platform have been basically completed. The Group’s unified e-commerce platform has achieved initial results relying on PICC P&C Insurance, and the Group’s unified health management platform has entered the construction and implementation stage relying on PICC Health. The third is to promote the construction of an integrated comprehensive risk management system with the focus on three projects. In order to meet the actual needs of the Group’s overall listing and consolidated risk management, the Group launched three projects, namely, risk preference system, economic capital model and risk basic data platform phase II, which were accepted on March 22nd. Through the gradual downward decomposition of the group’s overall risk preference (total risk), the risk budget is formed, and the risk management responsibility is implemented at all levels of the group company and subsidiaries, forming visible and tangible risk constraints, and unifying the decentralized risk management work under the two-level corporate governance structure of the group to the overall strategic objectives of the group. The completion of the three projects has unified the risk management policies of the whole group and improved the professional and technical level of risk management of the group.

  3. Strengthen business collaboration and enhance the overall competitiveness of the Group. Taking solving the cross-cutting problem of medical insurance business as the breakthrough point, we will focus on strengthening the cooperation between PICC P&C Insurance and PICC Health Business, promoting the cross-interaction among the three subsidiaries of Production, Health and Life Insurance, establishing a cooperative mechanism between the insurance sector and the investment sector, and enhancing the group’s joint efforts. First, vigorously rectify the lack of coordination in medical insurance business between PICC P&C Insurance and PICC Health. The Group has successively formulated and issued Opinions on Standardizing the Benefit Distribution Mechanism of Cross-selling, Cooperation Agreement on Jointly Carrying out Serious Illness Insurance for Urban and Rural Residents, and Notice on Further Strengthening the Cooperation of Serious Illness Insurance Business, resulting in malicious competition in informed criticism. The Plan of Health Insurance Reorganization and Integration of China People’s Insurance Group was formulated and implemented, which promoted the integration of medical insurance business through equity integration, and promoted the two subsidiaries of PICC P&C Insurance and PICC Health to deepen resource sharing and strengthen business collaboration in the fields of government-commissioned business such as medical insurance and health industry chain expansion. Formulate institutional measures to eliminate cross-business conflicts, clarify the responsibilities and rights of all parties, and reduce internal disorderly competition. The second is to strengthen the synergy mechanism between the investment sector and the insurance sector. The Group has established the Investment Committee for Strategic Asset Allocation, which serves as the investment decision support platform at the group level, with the participation of insurance companies and investment sectors, to collectively study and coordinate major issues such as major strategic investments and strategic asset allocation. The Group took the lead in establishing a regular roadshow mechanism for internal asset management products and building a communication platform between insurance companies and investment companies.Implement task decomposition and index assessment for the investment sector to drive the growth of insurance business. The investment assets of the three insurance subsidiaries in the group have all been entrusted, forming a unified investment standard. The third is to promote the development of cross-interactive business. Vigorously promote key projects such as the Group’s unified customer sharing platform, customer grouping management and in-depth analysis, and the Group’s integrated sales support platform, and constantly consolidate the foundation of customers and sales channels for cross-interaction. Focusing on the construction and improvement of key mechanisms such as "unified job number", cross-selling commission settlement and cross-selling into the basic law assessment, it has promoted the optimization of business processes and the establishment of interest mechanisms related to cross-interaction among the three subsidiaries of Production, Health and Life. Actively promote the co-construction and sharing of rural power grids and community stores, provide integrated insurance services rooted in the community, and build an efficient coordinated development mechanism. In 2015, China PICC Group realized cross-interaction premium income of 26.175 billion yuan, up 13.8% year-on-year.

  Third, take the opportunity of inspection and rectification to comprehensively deepen the strict management of the party and promote the sustained and healthy development of PICC Group.

  Two months’ comprehensive rectification has achieved phased results, but this is only a new starting point for China PICC Group to strictly manage the party in an all-round way. The Party Committee of the Group will continue to give full play to the positive energy of the special inspection by the Central Committee, thoroughly study and implement the spirit of the series of important speeches by the Supreme Leader General Secretary, further strengthen the main responsibility of managing the party and the party, and turn the positive energy inspired by the inspection and rectification work into a strong driving force for the Group’s reform and development with a more energetic spirit.

  (1) Strengthen responsibility and comprehensively promote the strict administration of the party.

  The Party Committee of the Group will further enhance its political consciousness, overall situation consciousness, core consciousness and conformity consciousness, strengthen its main responsibility, give full play to the leading core role of the Party Committee, and resolutely shoulder the "hard task" of managing the Party. Conscientiously implement the "one post and two responsibilities", deploy, implement and check the party building and the group management together, strengthen the accountability of assessment, and do a good job in the debriefing of party Committee secretaries and the evaluation of party building work, so as to truly turn the main responsibility into a "hard indicator". Improve and perfect the grass-roots party organizations, promote the standardization of grass-roots party building work, and put an end to the gradual weakening of party building work within the group. Adhere to the problem-oriented, "learning" should be guided by problem learning, and "doing" should be changed according to the problem. The study and education of "two studies and one doing" should be carried out in two levels, namely, the headquarters of groups and subsidiaries, provincial and lower branches, so as to effectively consolidate educational practice activities and the achievements of "three strictness and three realities" special education, promote the comprehensive and strict management of the party to the grassroots level, and provide a strong organizational guarantee for the integrated construction and customer-centered transformation and development of PICC Group.

  (2) Strengthen the accountability of supervision and discipline, and resolutely stand up discipline.

  Respect party constitution, strictly implement the Code of Integrity and Self-discipline in the Communist Party of China (CPC) and the Regulations on Disciplinary Actions in the Communist Party of China (CPC), effectively get rid of the idea of "enterprise particularity", adhere to discipline before the law, and resolutely put discipline and rules ahead. Make full use of the patrol sword and audit sharp weapon, use the "four forms", increase serious accountability, keep a close eye on the new forms and trends of "four winds", persistently implement the spirit of the eight central regulations, and resolutely prevent the "four winds" issue from rebounding. Adhere to the "double investigation of one case", and seriously investigate the responsibility of the parties, the main responsibility and the supervision responsibility of the units and departments that have serious violations of discipline. Carry out centralized rectification to solve the problem of frequent violations at the grassroots level. We should make great efforts to catch early and catch small, strengthen warning education, educate people around us with cases around us, let party member cadres always feel the power of organization and supervision, awaken and strengthen the sense of discipline and rules of all party member cadres in the Group, and strictly implement various rules of honesty and self-discipline. Conduct a party discipline education throughout the system, integrate discipline education into business work, and penetrate into all aspects of business management. Make full use of the "Handbook of Integrity Education in the Whole Process of Hierarchical Classification" and the "Handbook of Integrity Practice Red Line" compiled and distributed, strengthen the education of professional ethics and industry norms, raise the awareness of risk prevention and integrity practice, and let the cadres and employees be alert, clear the bottom line and know awe.Consciously obey the rules and discipline, resist corruption and prevent change.

  (3) Strengthen institutional mechanisms and consolidate the results of inspection and rectification.

  2016 is the "year of comprehensive rectification" determined by the Party Committee of China People’s Insurance Group, mainly to comprehensively implement the rectification tasks such as the special inspection of the central government, the audit of the National Audit Office, and the "review" of the rectification of the "four winds" by the Central Commission for Discipline Inspection, so as to comprehensively rectify and consolidate the results of the inspection and rectification. We will persist in the efforts of rectification, do a good job in the continuous promotion and "looking back" of inspection and rectification, and earnestly consolidate and improve. Adhere to the combination of governing the party according to regulations and governing enterprises according to law, and continuously improve various rules and regulations. The established system, with process management, procedural provisions, information means to improve the effectiveness of the system, enhance the implementation of the system; If the system is not perfect, it should be problem-oriented, focusing on the root cause and prevention. Strengthen and improve the daily supervision and special inspection of system implementation, improve the accountability mechanism and enhance the authority of the system. With the help of the risk preference system, the economic capital model and the second phase of the risk basic data platform, through the implementation of the internal control system framework model, we will establish a thorough supervision mechanism, build an integrated comprehensive risk management system with people’s insurance characteristics, tie up and tighten the system cage including the construction of party style and clean government, standardize business behavior fundamentally, and consolidate the management foundation of the group.

  (D) Strengthen the ability to implement the strategy and serve the country’s economic and social development.

  During the "Twelfth Five-Year Plan" period, by strengthening the party building work and continuously consolidating the political advantages of the group, a new pattern of China People’s Insurance Group was formed to strengthen the leadership of the party and promote scientific development. Guided by the spirit of the series of important speeches by the Supreme Leader General Secretary, the Party Committee of China PICC Group will firmly establish the development concept of innovation, coordination, green, openness and sharing, scientifically plan and implement the Group’s "Thirteenth Five-Year Plan" development blueprint, strictly manage the Party in an all-round way, continue to promote customer-centered transformation, maintain steady growth, concentrate on reform and innovation, strengthen value creation, enhance professional ability, deepen transformation and development, and keep the risk bottom line. Firmly establish a big pattern thinking, give full play to the function of insurance, participate in, serve and promote economic and social development more firmly, and make new and greater contributions to building a well-off society in an all-round way.

  This special inspection tour of the Central Committee is of great significance to promoting the Party building and company development of PICC China Group. We will take this inspection and rectification as an opportunity, resolutely follow the requirements of the "five in one" overall layout and the "four comprehensive" strategic layout, earnestly shoulder the political responsibility of managing the party, earnestly strengthen the party’s leadership over enterprises, and promote the sustained and healthy development of the Group with tangible rectification results.

  Cadres and the masses are welcome to supervise the implementation of inspection and rectification. If you have any comments, please report them to us in time.

  Tel: 010— 62616611 to 2061

  Address: Supervision Department of PICC Group, No.28 Tsinghua West Road, Haidian District, Beijing.

  Postal code: 100084

  Email: jubao@picc.com.cn

  Committee of China People’s Insurance Group Co., Ltd.

  April 25, 2016

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Announcement of Beijing Local Taxation Bureau and Beijing Environmental Protection Bureau on Issuing the Interim Measures for the Verification and Calculation of Beijing Environmental Protection Tax

No.3 of 2018

  The Interim Measures for the Verification and Calculation of Beijing Environmental Protection Tax are hereby promulgated and shall come into force as of January 1, 2018.

  It is hereby announced.

  Annex: 1. Table of Characteristic Value Coefficient of Sewage Discharge of Some Small Tertiary Industries (omitted)

     2. Water pollution equivalent value of livestock breeding, small enterprises and tertiary industry (omitted)

     3. Adjustment coefficient of dust emission from construction site (omitted)

     4. Construction site dust management grade standard (omitted)

     5. Policy Interpretation on the Announcement of Beijing Municipal Environmental Protection Bureau of Beijing Local Taxation Bureau on Issuing the Interim Measures for the Verification and Calculation of Beijing Environmental Protection Tax (omitted)

  Note: The attachment can be found on the official website of Beijing Local Taxation Bureau (www.tax861.gov.cn).

Beijing Local Taxation Bureau    

Beijing Municipal Environmental Protection Bureau    

March 29, 2018  

Interim Measures of Beijing Municipality on the Verification and Calculation of Environmental Protection Tax

Chapter I General Principles

  the first In order to improve the environmental quality of this Municipality, give full play to the role of taxation in promoting pollution control and emission reduction, and strengthen the collection and management of environmental protection tax, these measures are formulated in accordance with the provisions of People’s Republic of China (PRC) Environmental Protection Tax Law, People’s Republic of China (PRC) Tax Collection and Management Law and its implementation rules and other relevant laws and regulations.

  the second Taxpayers within the scope of this Municipality who cannot calculate the tax payable of air pollutants and water pollutants in accordance with the methods specified in Items 1 to 3 of Article 10 of the People’s Republic of China (PRC) Environmental Protection Tax Law shall verify and calculate the tax payable in accordance with the provisions of these Measures.

  The air pollutants and water pollutants mentioned in the preceding paragraph refer to air and water pollutants discharged by livestock breeding, small enterprises and some tertiary industries, dust (general dust, the same below) generated by construction sites, and sulfur dioxide generated by municipal gas facilities (burning municipal pipeline natural gas).

  Article The local tax authorities at all levels and the competent department of environmental protection shall establish a cooperation mechanism for the verification and calculation of environmental protection tax according to these Measures, and carry out the verification and calculation of environmental protection tax in an orderly manner according to the responsibilities of the departments.

  Article 4 Local tax authorities shall perform the following duties:

  (1) Incorporating taxpayers who meet the approved calculation into tax administration;

  (two) according to the latest pollution characteristic coefficient issued by the competent department of environmental protection, timely maintenance and adjustment of the approved tax-related data;

  (three) to supervise, verify and inspect the basic data of taxpayers’ production and operation, the basic situation of pollutant discharge and the payable amount of environmental protection tax.

  Article 5 The competent department of environmental protection shall perform the following duties:

  (a) the municipal environmental protection department is responsible for formulating and adjusting the sampling measurement methods of this Municipality; To supervise and control the sewage discharge of taxpayers approved for calculation;

  (two) responsible for providing the relevant information obtained in the supervision and management of environmental protection to the district tax authorities;

  (three) to cooperate with the tax authorities to implement the tax inspection of environmental protection tax according to law.

Chapter II Calculation Methods

  Article 6 Taxable amount of pollutants generated by catering industry (without sewage discharge metering equipment), accommodation industry, washing and dyeing service industry (clothing), beauty salon and health care industry, bathing industry (foot washing and bathing), automobile and motorcycle repair and maintenance industry, photography and printing service industry and independent coal-fired boiler that cannot be verified and calculated according to the methods specified in Item 1 to Item 3 of Article 10 of People’s Republic of China (PRC) Environmental Protection Tax Law is:

  Taxable amount = characteristic index value × pollutant discharge characteristic coefficient × specific applicable tax amount

  The characteristic coefficient of emission shall be implemented in accordance with the Table of Characteristic Coefficient of Sewage Discharge of Some Small Tertiary Industries attached to these Measures (see Annex 1). The specific applicable tax amount is the applicable tax amount of taxable pollutants in Beijing.

  Article 7 The taxable amount of water pollutants in livestock breeding, small enterprises, catering and entertainment services (with sewage discharge metering equipment) and hospitals that cannot be calculated according to the methods specified in Items 1 to 3 of Article 10 of People’s Republic of China (PRC) Environmental Protection Tax Law is:

  Taxable amount = pollution equivalent number × specific applicable tax amount

  The pollution equivalent number is calculated by dividing the characteristic value of pollution discharge by the pollution equivalent value, which shall be implemented in accordance with the Water Pollution Equivalent Value of Livestock Breeding, Small Enterprises and Tertiary Industry (see Annex 2) attached to these Measures. The specific applicable tax amount is the applicable tax amount of taxable water pollutants in Beijing.

  Article 8 The taxable amount of dust generated by the construction site of the construction project is:

  Taxable amount = land area of construction site × 0.065 × construction period × adjustment coefficient of dust emission of construction site × specific applicable tax amount.

  The land area of the construction site of the construction project is the land area of the construction unit (including the agent). The construction period shall be calculated on a monthly basis. If the construction period is less than one month, the construction period shall be converted according to the actual construction days in different construction stages divided by the actual days in the current month. The adjustment coefficient of dust emission on the construction site shall be implemented in accordance with the Adjustment Coefficient of Dust Emission on the Construction Site attached to these Measures (see Annex 3). The specific applicable tax amount is the applicable tax amount of taxable air pollutants in Beijing.

  ninthstrip Construction sites include housing construction sites (including industrial plants), decoration sites, municipal infrastructure sites, demolition sites, greening sites, water sites, highway sites, railway sites, etc. within the administrative area of this Municipality.

  Article 10 The construction unit (including the agent) construction land area is determined according to the following methods:

  (a) according to the land, planning, housing and urban-rural construction departments issued by the state-owned land use certificate, the construction project planning conditions from the construction land planning permit (the construction project planning permit from building construction permits), the house ownership certificate or the immovable property certificate, as well as the approval documents of the administrative departments with approval authority or other relevant materials;

  (two) the main technical parameters such as length, width and pipe diameter should be provided when the area of linear projects such as highways, railways, water affairs and pipe networks is approved;

  (three) there is no relevant approval documents to prove the construction area of the project, the construction unit shall calculate the construction area according to the actual land area.

  Article 11 If the construction site of a construction project meets the Class II standard in the Grade Standard for Dust Management of Construction Sites attached to these Measures (see Annex 4) and meets the Class I standard, the tax payable shall be calculated according to the reduction factor of 50%; If it only meets the second-class standard, the tax payable shall be calculated according to the reduction factor of 100%; If the second-class standard is not met, the tax payable shall be calculated according to the reduction factor of 200%.

  If there is grade standard information in the dust management of the relevant government departments in the construction site of the construction project, the tax authorities shall determine the reduction coefficient based on this information.

  Article 12 The taxable amount of sulfur dioxide generated by gas facilities (burning municipal pipeline natural gas) that cannot be actually monitored is:

Taxable amount of sulfur dioxide

Chapter III Approval Methods

  Article 13 Taxpayers who meet the approved calculation conditions should fill in the Basic Information Collection Form of Environmental Protection Tax when registering the tax source of environmental protection tax for the first time, submit it to the competent tax authorities, and be responsible for the authenticity of the application materials.

  Article 14 Taxpayers who implement the approved calculation meet the calculation conditions of taxable pollutants stipulated in Items 1 to 3 of Article 10 of the People’s Republic of China (PRC) Environmental Protection Tax Law by installing, monitoring and measuring the emissions of atmospheric and water pollutants. If these measures are no longer applicable, they should re-fill in the Basic Information Collection Form of Environmental Protection Tax in the next month after the change, and make tax returns according to law.

  Article 15 When taxpayers file tax returns, they shall file and fill in the tax returns according to the following circumstances:

  (1) Taxpayers who are subject to the provisions of Article 12 of these Measures shall fill in the Environmental Protection Tax Declaration Form (Form A) to declare and pay taxes.

  (2) Taxpayers who apply other methods of these Measures shall fill in the Environmental Protection Tax Declaration Form (Form B) to declare and pay taxes.

  Article 16 These Measures shall be interpreted by Beijing Local Taxation Bureau and Beijing Environmental Protection Bureau.

  seventeenthArticle These Measures shall come into force as of January 1, 2018.

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A number of convenient services smooth the flow of Spring Festival travel rush logistics "artery" China is full of vitality

  CCTV News:In 2024, in Spring Festival travel rush, the proportion of cross-regional personnel mobility and self-driving travel will reach a record high, and the business passenger traffic will rebound in an all-round way. On January 16th, the Ministry of Transport said that it would take countermeasures in advance to ensure the organization, service and safety of passenger and freight transportation in Spring Festival travel rush.

  Li Yang, Vice Minister of the Ministry of Transport, said that during his stay in Spring Festival travel rush, he would strengthen the synergy between different modes of transport, promote the optimization of security inspection procedures for railways, civil aviation and urban rail transit, vigorously develop intermodal transport service products such as air-rail combined transport and Komba combined transport, and enhance the comprehensive transport service capacity.

  The transportation department will also strengthen the tracking and monitoring of key scenic spots, strengthen the information sharing of passenger flow and transportation capacity, and increase the transportation capacity in a targeted manner. At the same time, we will increase the care and attention of key groups such as "old and young, sick and pregnant", refine the implementation of humanized service measures such as ticket purchase and waiting, and comprehensively promote services such as online ticket purchase and self-service ticket inspection.

  Ensure the efficient and convenient passage of people’s livelihood materials

  During the period of Spring Festival travel rush, there is a strong demand for transportation of key materials, such as warm energy and people’s livelihood materials. The Ministry of Transport said on January 16 that it will comprehensively implement policies to ensure the smooth and orderly transportation of key materials and people’s livelihood materials.

  The Ministry of Transport has formulated a transportation guarantee plan to strengthen the emergency transportation capacity reserve to ensure the orderly transportation of key materials and people’s livelihood materials in emergencies. Strictly implement the "green channel" policy for the transportation of fresh agricultural products to ensure the efficient and convenient passage of all kinds of vegetables, fruits and other livelihood materials.

  The demand for new year’s goods increased, and there was a small peak in pre-holiday delivery.

  The State Post Bureau said on January 16th that the demand for delivery services fluctuated greatly during Spring Festival travel rush. On the eve of the Spring Festival, with the growth of the demand for new year’s goods delivery, there will be a small peak of business volume higher than the daily level. During the Spring Festival holiday, due to a large number of people returning home for the New Year and traveling abroad, the public’s demand for delivery services will be significantly reduced, and the business volume is also in a low season. After the Spring Festival holiday, the demand for delivery services will recover rapidly, and the business volume will gradually return to the daily level.

  During the Spring Festival, on the one hand, the State Post Bureau urged postal enterprises to continue to provide universal postal services. On the other hand, guide express delivery enterprises to scientifically predict the changes in business demand during the Spring Festival, ensure the maintenance of basic service capabilities during the Spring Festival, rationally arrange production and operation, timely announce service arrangements to the public and strictly fulfill the contents of announcements and commitments.

  The State Post Bureau will also strengthen the dynamic monitoring of post-holiday personnel’s return to work, actively help delivery enterprises to supplement their personnel strength in various ways, and urge terminal outlets and distribution centers to quickly restore their normal service capabilities to ensure the normal operation of the delivery service network as soon as possible.

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Is cell therapy reliable in treating cancer? CAR-T leads the world, and 10 popular and emerging cellular immunotherapy show their magical powers!

The incidence of malignant tumor is increasing year by year, which has become a common problem faced by human beings. Traditional treatment methods such as surgery, traditional chemotherapy and radiotherapy have always played a leading role in cancer treatment, but the effects of these treatments are limited. In particular, it is difficult for advanced patients to benefit from these treatments for a long time, nor can they fundamentally solve or change their quality of life. Therefore, researchers are increasingly focusing on the field of immunotherapy. Immunotherapy has brought new opportunities and hopes for the treatment of tumors, among which Immunocheckpoint inhibitors, therapeutic antibodies, tumor vaccines, immunomodulators, adoptive cell therapy, etc. Significantly improved the prognosis of cancer patients, and some patients with advanced cancer obtained long-term survival. In the past two years, many cellular immunotherapy have emerged and developed rapidly, which undoubtedly set off a wave of cancer treatment. So, is cell therapy reliable in treating cancer? In fact, immunotherapy has a history of more than 100 years, and it has only gradually entered the public’s field of vision in the last two years, and it has been absolutely recognized by the world oncology community.   

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A milestone in the history of cancer immunotherapy In 2013, Science magazine ranked the top ten scientific breakthroughs of the year, and immunotherapy topped the list. In recent years, immunotherapy is one of the hot spots in the research field of tumor treatment at home and abroad, and a large number of clinical studies have shown exciting results. Among them, Cellular immunotherapy uses the self-protection and killing ability of human immune system to achieve anti-tumor effect. Cells with immune function in patients are cultured and proliferated in vitro, and they are given the ability to attack tumor cells by technical means, and then they are imported into patients to realize their own anti-cancer. This therapyAgainst immune cells, not cancer cells.It is not as harmful to the patient’s health as surgery, radiotherapy and chemotherapy. Patients with early cancer can be treated directly, especially with the attack on residual cancer cells after surgery. Judging from the rapid development in scientific research and clinic in recent years, cellular immunotherapy is expected to become the fourth pillar of anticancer therapy in terms of accuracy, effectiveness and safety. Next, the small series of Cancer-free Home gives a general introduction and inventory of a variety of popular and emerging cellular immunotherapy in the biomedical industry, hoping to give cancer friends a general understanding of the general development process of this cancer treatment field. 

0one  CAR-T cell therapy

CAR-T therapy is chimeric antigen receptor T cell immunotherapy, which is a new precise targeted therapy for treating tumors. T cells are activated by genetic engineering technology, and the positioning navigation device CAR (tumor chimeric antigen receptor) is installed to transform the ordinary "warrior" of T cells into "super warrior" CAR-T cells, Specially identify tumor cells in vivo and kill tumor cells efficiently. So as to achieve the purpose of treating malignant tumors. At present, with 2021, Aquilencel injection, Regioscel injection. It was approved for listing in China, in 2022.Cedarchiorense was approved for listing by FDA.CAR-T therapy is expected to enter the blowout period. Indeed, CAR-T technology has shown good curative effect in many hematological tumors, such as leukemia, lymphoma and multiple myeloma, and more than half of hematologic cancer patients who are on the verge of despair and have no cure have achieved good curative effect.  

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CAR-T cell therapy has been listed at home and abroad at present.

Although the clinical effect of CAR-T therapy on solid tumors is not satisfactory, and it has even been sung down by some people, in recent years, CAR-T therapy has made outstanding progress in the fields of gastric cancer, liver cancer and pancreatic cancer. Scholars at home and abroad have made various modifications to CAR-T, and constantly found new targets for the treatment of various solid tumors.    

Clinical study on CAR-T therapy is out of the loop.

0one Gastric cancer and pancreatic cancer As the first CAR-T cell targeting Claudin18.2 in the world, CT041 emerged as early as the ASCO annual meeting in 2019. At that time, the total objective remission rate was 33.3%, which already surprised the world. Now the more remarkable curative effect is undoubtedly the icing on the cake! This clinical data shows a good treatment prospect for digestive system tumors!

Domestic CAR-T therapy CT041 first appeared in ESMO

Developed by Keji Pharmaceutical at the annual meeting of the European Society of Oncology (ESMO) in 2021.Targeting Claudin18.2(CLDN18.2)Autologous CAR-T candidate productsCT041Showing its presenceDigestive system tumorThe outstanding curative effect can be described as brilliant!

The research data is particularly eye-catching!

1. All patients’The objective remission rate was 48.6%, and the disease control rate was 73%.All patients with gastric cancerThe total objective remission rate was 57.1%.

2. Patients with gastric cancer who failed to receive at least 2 lines of treatment in the past:The objective remission rate was 61.1%, and the disease control rate was 83.3%.

3. And the overall tolerance is good!

As of March 3, 2022,CT041 became the first and only CAR-T cell candidate product in the world for the treatment of solid tumors, which entered the confirmatory phase II clinical trial.This is a milestone for CAR-T to conquer the solid tumor field. Congratulations!

In addition, there are many CAR-T cell therapies targeting CLDN18.2.0 2 liver cancer At present, the clinical trial targets of CAR-T in the treatment of liver cancer are mainlyGPC3 (phosphatidylinositol proteoglycan 3). The breakthrough research results completed by Professor Zhai Bo, director of the Department of Tumor Interventions, Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine, were published in the international authoritative journal Clinical Cancer Research on May 5, 2020. By July 24th, 2019, 13 patients had received CAR-GPC3 T cells with a median value of 19.9×108. All the patients are GPC3 positive, and they have received surgical treatment, local treatment or systemic treatment, and they all carry hepatitis B virus (HBV). Two patients achieved partial remission (PR). The 6-month, 1-year and 3-year survival rates of all patients were 50.3%, 42.0% and 10.5% respectively, and the median survival time (OS) was 278 days (39.7 weeks). At the ASCO annual meeting in 2021, Chinese medical researchers published the latest clinical research data of CAR-T drug targeting GPC3 (Ori-CAR-001) in the treatment of recurrent/refractory hepatocellular carcinoma for the first time. As of March 10, 2021, a total of 11 recurrent subjects who received cell infusion were included.All the subjects had advanced hepatocellular carcinoma, and none of them were effective after chemotherapy, TACE (transcatheter arterial chemoembolization) and targeted therapy.Of the 9 evaluable subjects,4 cases achieved partial remission (PR), 3 cases achieved disease stability (SD) and 2 cases developed disease progression (PD).The objective remission rate was 44%, and the disease control rate reached 78%.. 

02  Treatment of tumor infiltrating lymphocytes (TIL)

TILs therapy, simply speaking, is to separate and purify the lymphocytes in the tumor tissue after surgery, select the lymphocytes that can specifically resist cancer, and then amplify and activate them and reinfusion them. This kind of therapy has a history of more than 30 years, and it was first used for malignant melanoma. In recent years, it has given good data in many solid tumors such as cervical cancer and lung cancer.

This therapy is equivalent to pulling back veterans with combat experience directly from the battlefield. After a round of "political review" and "big competition" in professional ability, the spies and traitors are eliminated as far as possible, leaving the ones with the strongest fighting capacity, providing supplies, and then sending them back to the battlefield to continue fighting. Looking at the whole industry, the voice of "innovative therapy based on Tiles cells LN-144 (Lifelecel) is expected to be approved in 2022" is particularly loud. Tiles therapy, as an "ancient" cell therapy, is expected to usher in the first approved product this year, and its great potential in treating solid tumors can not be underestimated, with strong strength and relatively "out of the circle". TILs domain key node event     In 1982  

Steven A.Rosenberg and others discovered for the first time that TILs can inhibit the metastasis of melanoma cells in patients.

  1988  

The earliest attempt of TILs in clinical treatment: TILs therapy for metastatic melanoma achieved an objective remission rate of 60%.

  In 2011  

Steven A.Rosenberg and others published a phase II clinical research data in Clinical Cancer Research: the objective remission rate (ORR) and complete remission rate (CR) of patients with melanoma treated by TILs were 56% and 24% respectively.

  In 2012  

Melinda Bachini, a patient with advanced intrahepatic cholangiocarcinoma, is called the first patient to achieve complete remission (CR) after TILs therapy.

  2019  

At the ASCO meeting, the clinical results of innovative therapies LN-145 and LN-144(Lifileucel) based on TILS cells in the treatment of cervical cancer and melanoma have attracted wide attention in the medical field.FDA awarded LN-145 breakthrough therapy recognition.

  In 2021  

Phase I clinical results of TILs cell therapy at AACR meeting: among 12 evaluable patients.Non-small cell lung cancer patientsMedium,TIL therapy can achieve a total remission rate of 25%, among whichTwo patients achieved lasting complete remission.

  In 2021  

At the annual meeting of tumor immunotherapy association (SITC), the clinical research results of LN-145 in the treatment of metastatic non-small cell lung cancer (mNSCLC) showed that in 28 cases,In patients with recurrent/refractory mNSCLC,After LN-145 monotherapy,The overall remission rate (ORR) was 21.4%(1 case of CR and 5 cases of PR, including 2 cases of PD-L1 negative tumors), 12 cases were stable, and the disease control rate (DCR) was 64.3%.

03  TCR-T therapy

CAR-T cells and TCR-T cells belong to T cells modified by genetic engineering technology.Compared with CAR-T therapy, TCR-T therapy has unique advantages in the field of solid tumor treatment. TCR-T cell therapy can identify tumor-specific antigens from cell membrane surface or intracellular sources, and has entered clinical application from the initial basic immune research, showing initial efficacy in solid tumors, and has become the most likely T cell immunotherapy to make a breakthrough in the field of solid tumors! 

1、 TCR-T cell therapy in China has been approved for clinical use and has become a potential new therapy for HBV-related hepatocellular carcinoma!

At present, in addition to the global TCR-T in full swing in the research and development and clinical verification stage, China is also constantly breaking through innovation.

On December 22nd, 2021, CDE (Drug Evaluation Center) official website was able to inquire about the clinical application of "SCG101 Autologous T Cell Injection", which is a TCR-T cell therapy for specific hepatitis B virus (HBV) epitopes and a potential new therapy for HBV-related hepatocellular carcinoma (HCC).

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▲ Image source: CDE official website

2、 Advanced liver cancer ushered in a new dawn! TCR-T therapy makes cancer patients completely relieved.

As early as 2020 International Hepatology Conference (ILC), ADP-A2AFP, a new TCR-T therapy for liver cancer based on T cells, caused quite a stir, and also made a new breakthrough in the new therapy for liver cancer.

Among the included patients,One patient showed a complete remission (CR) in cancer progression, and the AFP of the other participants also decreased to varying degrees.This means that the experiment has made progress, and it also shows that this therapy is effective for the treatment of advanced liver cancer.

             

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All the 9 patients involved had undergone surgery and conventional radiotherapy and chemotherapy, but failed or became intolerant. Among the 4 patients who received the highest dose of treatment,One patient achieved complete remission, and CT scan showed that all the lesions in the patient disappeared, and it has lasted for more than half a year without any recurrence!

The best response of other patients (cohort 1, cohort 2) is stable. 1 patient in queue 2After one month of treatment, the volume of the primary lesion did not decrease, but the volume of mediastinal lymph node metastasis decreased obviously!       

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Therefore, TCR-T therapy targeting AFP (alpha-fetoprotein) can kill tumor cells expressing AFP. Based on the positive results of this study, researchers are expected to expand the maximum dose to 5 billion cells, and we look forward to the publication of updated data of this study!

04  CAR-NK therapy

In recent two years, in addition to CAR-T therapy, another new cancer cell therapy- Natural killer (NK) cell therapy It has also gradually attracted attention. The researchers said, NK cell As a cell anticancer therapy, it has more potential, and it may be safer, cheaper and faster. CAR-NK is to add a chimeric antibody to NK cells by genetic engineering that can recognize tumor cells and activate NK cells to kill tumor cells at the same time. 

one   The first "spot" CAR-NK clinical trial in China was approved by the Food and Drug Administration. On November 11, 2021, National Medical Products Administration Drug Evaluation Center passed an independent research and development in China. Mesothelin (MSLN) chimeric antigen receptor NK cells (CAR-NK) injection for the treatment of advanced epithelial ovarian cancer. Application for clinical trial of CAR-NK injection. According to the cancer-free home, This product is the first "spot" CAR-NK product of foreign origin in China. This also marks a new milestone in the research of immune cell drugs in the treatment of solid tumors in China! 

2  The 1-year survival rate doubled, and the curative effect of CAR-NK therapy in solid tumor increased sharply.

Recently, the journal Clinical Oncology Research published a phase II clinical trial for lung cancer. Heat shock protein 70(Hsp70) is highly expressed in about 70% of middle and advanced lung cancer. NK cells are activated by Hsp70 in vitro, which is equivalent to making NK cells meet their future enemies in vitro, "making enemies" first, and then returning them to patients, so that NK cells can formally fight with cancer cells in vivo. This method of stimulating NK cells with antigen peptides in vitro and giving them certain specificity is a hot topic in recent years.

A total of 16 patients with stage III non-small cell lung cancer were enrolled in this clinical trial. One group received traditional chemotherapy combined with radiotherapy and chemotherapy, and the other group received chemotherapy combined with Hsp70 pre-stimulated NK cell reinfusion.

The results show that:The one-year survival rate can be doubled from 33% to 67% by Hsp70 pre-stimulated NK cell reinfusion therapy combined with traditional radiotherapy and chemotherapy, and the preliminary results are encouraging.

Next, Xiaobian shows a typical successful case in combination therapy, as shown in the figure:After 1~2 months of treatment, the lung tumor completely disappeared and the curative effect has been maintained for 18 months.

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In addition to the above-mentioned clinical studies at home and abroad, CAR-NK cells also have a good effect on glioblastoma and neuroblastoma, specifically recognizing and killing breast cancer cells with high efficiency, and have a remarkable effect on multiple myeloma.

05  Dendritic cell vaccine

Cancer vaccine is a form of immunotherapy, which can prevent cancer from developing or kill existing tumors by stimulating or restoring the human immune system. Dendritic cell (DC) vaccine is a new biological therapy for malignant tumor in recent years, which has been paid more and more attention and recognized by oncologists. As an important member of the human immune defense system, Dendritic cells have the strongest antigen presenting function and are known as "sentinels" of the immune system. It is named because its cells extend outward with many dendritic protrusions. It mainly uses modern high-tech biotechnology to collect the peripheral blood of tumor patients, induce and cultivate a large number of dendritic cells in a short time in vitro, and equip them with immune cells that patients do not have, so as to accurately "target" and kill cancer cells. Not only that, It can also induce immune memory in patients, so that patients can obtain long-term anti-cancer effect.

DCVAC/LuCa is a dendritic cell vaccine developed by the United States for patients with non-small cell lung cancer.In a study on the first-line treatment of advanced lung cancer announced at the ASCO conference in 2019, DCVAC/LuCa vaccine combined with chemotherapy groupThe objective remission rate is 45%,The median overall survival time was 15.5 months, and the median progression-free survival time was 6.74 months.Reduce the risk of death by 46%!

In the Phase II clinical study of the latest novel dendritic cell vaccine DCVAC/LuCa (lung cancer dendritic cell vaccine) combined with standard carboplatin/pemetrexed in the treatment of advanced non-squamous cell (nsq) non-small cell lung cancer in 2022,The 1-year survival rate was 72.73% and the 2-year survival rate was 52.57%.By the time the data was published, the median overall survival time had not been reached. The median progression-free survival time was 8.0 months, and the objective remission rate was 31.82%.

  Prostate cancer-Provenge vaccine  

Provenge is the first vaccine approved for treatment in the United States, which initiated a new era of cancer immunotherapy.This is an autologous cell immunotherapy, which was approved by FDA on April 29, 2010 to treat asymptomatic or mild mCRPC. This approval marks the success of 20 years of unremitting efforts.In the United States, Provenge is the only FDA-approved immunotherapy for prostate cancer made from patients’ own immune cells.

  Ovarian cancer-dcvac/ovca vaccine  

At the 50th annual meeting of the Society of Gynecological Oncology (SGO) in 2019, the final result of SOV02, a phase II clinical trial, was announced: DCVAC/OvCa, an immunotherapy based on dendritic cells, was added to standard carboplatin and gemcitabine schemes for patients with recurrent, platinum-sensitive and epithelial ovarian cancer.It can prolong the overall survival (OS) of patients with advanced recurrent ovarian cancer by more than one year.andDCVAC/OvCa reduced the death risk of second-line treatment of ovarian cancer by 62%. The overall survival (OS) increased significantly by 13.4 months. The median progression-free survival rate (mPFS) increased by 1.8 months. The global phase III study will be launched soon.

Melanoma-TLPLDC vaccine

The subgroup analysis results of the phase IIb clinical trial of TLPLDC vaccine in the treatment of melanoma were published at the ASCO-SITC Clinical Immunooncology Conference in 2020.

In that population analysis follow the clinical research protocol (PT), compared with the comfort unit,The 24-month disease-free survival rate in TLPLDC treatment group was significantly improved (62.9% vs 34.8%), indicating that the relative risk of disease recurrence was reduced by nearly 50%.

In the population analysis of Intentional Treatment (ITT),There was no significant improvement in 24-month disease-free survival between TLPLDC treatment group and placebo group (38.5%) vs 27%),But in this analysis,The improvement trend of 24-month overall survival rate (OS) was stronger (86.4% vs 75.1%)..

  Kidney Cancer-Ilixadencel Vaccine  

Ilixadencel is an allogeneic dendritic cell (DC) vaccine. Research shows that,Ilixadencel combined with targeted anticancer drug sunitinib(Sotan, common name: sunitinib)First-line treatment of newly diagnosed advanced metastatic renal cell carcinoma(mRCC)Compared with patients treated with sunitinib alone, the total remission rate is doubled, the complete remission rate is higher and the remission is more lasting!

  Glioblastoma-AV-GBM-1 vaccine   On June 8, 2021, well-known foreign biomedical companies announced the release of phase II clinical trial data of their personalized cancer vaccine AV-GBM-1. The research shows that this new vaccine has great potential for prolonging the overall survival of newly diagnosed glioblastoma patients in the medium term. The median progression-free survival time of patients was 10.4 months, which was about 50% higher than the median progression-free survival time of 6.9 months in the landmark STUPP study, and established a nursing standard for newly diagnosed glioblastoma patients.     Non-small cell lung cancer-tedopi vaccine  

On April 1st, 2020, a new anti-cancer vaccine, TEDPI, achieved positive results in the phase III clinical trial of non-small cell lung cancer. After the immune checkpoint inhibitor (PD-1) was resistant or failed, all patients in the group used TEDPI vaccine in the second or third line, and the overall survival rate for one year reached 46%, far exceeding the preset 25%!

A 54-year-old patient with advanced lung cancer has rapidly shrunk (from 39mm to 23mm) after five injections of the new lung cancer vaccine. At the time of reporting, his survival time has exceeded 20.6 months, and he is still being followed up.

06  CIK cell therapy

  CIK cells, that is, Cytokine-Induced Killer (CIK), are a new type of immunocompetent cells, which have strong proliferative ability and cytotoxicity, and have certain immune characteristics. Because this cell expresses both CD3 and CD56 membrane protein molecules, it is also called NK cell (natural killer cell)-like T lymphocyte, which has both the strong anti-tumor activity of T lymphocyte and the non-MHC-limited anti-tumor advantage of NK cell. If NK cells are the "first line of defense" to protect human health, then CIK cells are undoubtedly the "precision missiles" to kill tumor cells. Especially for patients after surgery or radiotherapy and chemotherapy, it can eliminate residual tiny metastatic lesions, prevent cancer cells from spreading and recurring, and improve immunity. Therefore, CIK cells are considered as the first choice for a new generation of adoptive cellular immunotherapy for tumors. Research progress of representative CIK cell therapy     

nasal pharyngeal cancer  

Among 137 patients with nasopharyngeal carcinoma treated by CIK, 50% of them improved their survival time by 6-9 months, and among 137 patients treated by CIK, 50% of them delayed their tumor progression by 6-7 months.

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  liver cancer  

Among the 819 patients with liver cancer treated by CIK, 50% of them improved their survival time by 13~25 months, and among the 819 patients treated by CIK, 50% of them delayed their tumor progression by 4~7 months.

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  ovarian cancer  

Among 72 patients with ovarian cancer treated by CIK, 50% of them have improved their survival time by 24 months. Among 72 cases of ovarian cancer treated by CIK, 50% of ovarian cancer patients delayed their tumor progression by 14.5 months.

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carcinoma of colon

Among 126 patients with colon cancer treated by CIK, 50% of them have a longer survival time of 30 months. Among 126 patients with colon cancer treated by CIK, 50% of them delayed their tumor progression by 14.5 months.

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  breast cancer  

The probability that the survival time of 150 breast cancer patients treated with CIK can reach 5 years is increased to 85.7%; The probability of keeping breast cancer from recurring in 150 breast cancer patients treated with CIK within 5 years increased to 72.3%.88231650935357798

  Solid tumor  

Of the 31 patients treated with PD-1 antibody combined with DC-CIK, 2 patients’ tumors completely subsided and 5 patients’ tumors partially subsided. Of the above 7 patients, 6 patients’ effects can be maintained for 5 months. The tumors of the other 13 patients remained stable.

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  renal carcinoma  

Among 43 patients with advanced renal cell carcinoma treated by CIK, 50% of them can delay the tumor progression to 14.7 months.

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07  CAR-M therapy 

In recent years, the study of macrophages has also been paid attention to by the industry. How to activate the anti-tumor activity of these macrophages is the direction that immunologists have been working hard. CD47, an immune checkpoint on macrophages, has become a very promising hot target in the field of tumor immunotherapy.

In a recent study published in Nature Biotechnology, researchers from perelman Medical College of the University of Pennsylvania and other research institutions may have an alternative to T cell therapy to overcome these challenges. Their research shows that genetic modification of macrophages (an immune cell that devours intruders in vivo) may be the key to developing effective cell therapy for solid tumors. They were able to confirm these genetically modified expressions. The macrophages of CAR (CAR-M) can kill tumors in human samples and mouse models in the laboratory and prolong their life.   

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CAR-M therapy is centered on macrophages, which devour invading cells instead of destroying them like T cells. T cells are more like Space Invaders games, while macrophages are more like Pac-Man games. Another major difference between macrophages and T cells is that they are the first responders of the body to virus infection. Historically, this poses a challenge in trying to genetically modify them to attack cancer, because macrophages are not easily transfected by standard viral vectors used in gene therapy and cell therapy.

In this experiment, the research team used genetic engineering technology to transform macrophages. They not only expressed CAR targeting HER2 antigen, but also were activated and differentiated into M1 macrophage types that promoted inflammation. In this way,These CAR-M cells can not only target tumor cells, but also change the microenvironment near tumors by secreting pro-inflammatory cytokines. They can also present tumor antigens to T cells and activate T cells’ immune response to tumors, which can be described as "killing three birds with one stone".

On March 18th, 2021, Carisma Company of the United States announced the completion of the first drug delivery to the subjects of CAR-M therapy (CT-0508) targeting Her2, marking a new era of CAR-M transformation therapy for solid tumors. In a word, taking macrophages as effector cells transformed by CAR is expected to reverse the tumor inhibitory microenvironment, so as to break through the obstacles of immune cell therapy in solid tumors. 

08  CTL (cytotoxic T lymphocyte) therapy

What cell therapy can be used as an adjuvant therapy for the majority of patients with inoperable advanced cancer? In recent years, researchers have been developing new immunotherapy schemes for these patients, including CTL(cytotoxic T lymphocytes) technology. This technology mainly uses protein, which is unique to cancer cells and has no or low content in normal cells, as bait to select the truly anticancer lymphocytes in peripheral blood, and then further improve and amplify them in vitro, and then return them to patients. MTCA-CTL immunotherapy is a new generation of biological immunotherapy model introduced in China. While ensuring the expansion of non-MHC-restricted killer NK-T cells, directional expansion of HC-restricted CD8++specific CTL cells can make its proportion in cell products reach 60% ~ 70%. The combined effect of this killer cell makes the efficiency of killing tumor cells higher.  

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At present, the multi-target compound antigen peptide biological immunotherapy technology, which is undergoing the second phase of clinical trials in the Cancer Hospital of China Academy of Medical Sciences, is the fifth and brand-new generation of cellular immunotherapy technology, which can optimize the activation method of DC (dendritic cells) to enhance the killing effect of immune cells on tumor cells. At present, it has achieved good clinical results and I believe it will really benefit cancer patients.

Mainly suitable for solid tumors.Head and neck tumor, esophageal cancer, lung cancer, gastric cancer, breast cancer, liver cancer, membranous adenocarcinoma, colorectal cancer, ovarian cancer, uterine cancer, coma cancer, prostate cancer, malignant melanoma, sarcoma and partial malignant lymphoma.

If economic conditions permit and you want to consult MTCA-CTL therapy, you can contact.Cancer-free Home Medical Department (400-626-9916), a detailed assessment of the condition.

09  CAR-NKT therapy

  Natural killer T cells (NKT) are a group of special T cell subsets that express both T cell receptors (TCR) and NK cell receptors on the cell surface, and can produce a large number of cytokines. Such as IL-4 and INFγ. These cells can not only directly dissolve and kill tumor cells, but also play an anti-tumor role through indirect ways (secreted cytokines, activated immune cells, etc.). Recently, a phase I clinical trial jointly conducted by Baylor Medical College in Houston and Texas Children’s Hospital is evaluating a new treatment for children with recurrent neuroblastoma –CAR-NKT cell therapy is expected to break through this bottleneck. Phase I trial, code-named GINAKIT2, used CAR-NKT cells for the first time to treat recurrent neuroblastoma. Eleven children (1~21 years old, with an average age of 7 years old) were all recurrent/refractory high-risk neuroblastoma, with extensive metastasis and no better treatment plan in clinic. The results are very encouraging: Of the 11 advanced patients, The condition of 4 patients was stable, 2 patients achieved partial remission (tumor was obviously reduced), and one of them had complete remission (CR) after receiving the second CAR-NKT cell infusion. In safety, CAR-NKT is safer than CAR-T therapy. No dose-limiting toxicity was observed in the first 28 days after infusion. 

10  Compound immune cell therapy

This technology will alsoSix kinds of cells, such as γδT cells, NK cells, NKT cells, killer T cells, dendritic cells and helper T cells.Activate, multiply 10 million to 20 million cells to 2 billion to 5 billion cells, and then inject them into patients. Cultivating such important immune cells at the same time greatly improves the therapeutic effect compared with single treatment.

Except for some leukemia and malignant lymphoma,It can be used for the treatment of most cancers, and has a good effect in refractory cancer types and advanced cancers. Besides,Compound immune cells also play a great role in improving immunity and strengthening the body.

Xiaobian has something to say

In recent years, due to the development of medical level, new cancer treatment methods have appeared one after another, among which cellular immunotherapy is in full swing, which brings new hope to cancer patients. According to the latest statistics, compared with patients with advanced lung cancer, gastric cancer and liver cancer who only receive surgery, radiotherapy and chemotherapy, adjuvant cellular immunotherapy can prolong the survival time of patients and significantly improve the data effect. In fact, tumor treatment is actually a complex "project", and it is difficult to achieve good results by relying solely on a certain treatment method. Tumor treatment needs the cooperation of various treatment methods to achieve the final victory in the fight against cancer. 

通过admin

Beijing issued a policy notice on optimizing the medical insurance for patients infected with Covid-19.

"Beijing Medical Insurance" WeChat WeChat official account issued the "Policy Notice on Optimizing the Medical Insurance for the Treatment Expenses of Infected Patients in novel coronavirus". In order to conscientiously implement the decision-making arrangements of the CPC Central Committee, the State Council, the Municipal Party Committee and the Municipal Government, and according to the requirements of the Notice of the National Medical Insurance Bureau, the Ministry of Finance, the National Health and Wellness Commission and the National Disease Control Bureau on Optimizing the Medical Insurance Related Policies for the Treatment Expenses of Infected Patients in novel coronavirus after the Implementation of "Class B Management" (No.1 of Medical Insurance Fa [2023]), this Municipality has optimized and adjusted the medical insurance related policies to ensure that the people can spend the peak period of infection smoothly.

  First, hospitalization reimbursement

  Novel coronavirus infected patients in all medical institutions, in line with the novel coronavirus infection diagnosis and treatment plan formulated by the health department of hospitalization medical expenses, the implementation of the pre-cost security policy, by the basic medical insurance, serious illness insurance, medical assistance and other reimbursement, personal burden part of the financial subsidies. This policy is based on the time of admission of patients and will be implemented until March 31, 2023.

  Second, outpatient and emergency reimbursement

  Novel coronavirus infection and 11 kinds of suspected symptoms (fever, dry cough, fatigue, pharyngalgia, decreased sense of smell/taste, stuffy nose, runny nose, conjunctivitis, myalgia and diarrhea) of the insured patients occurred in the designated medical institutions at or below the second level in this city, and the related emergency expenses were specially guaranteed, with no deductible line and no capping line, and the reimbursement ratio was 90%, which was implemented first until March 31, 2023.

  Due to the policy adjustment, when the insured patients seek medical treatment in the outpatient and emergency departments of the designated medical institutions at or below the second level in this city, the medical expenses incurred will be reimbursed first according to the previous medical insurance policy, and the reimbursement difference will be automatically made up through the information system in April according to the medical information of the insured patients uploaded by the medical institutions (from January 8 to March 31). The make-up fee will be directly paid to the personal entrusted bank account registered by the insured, and the insured personnel need not declare it by themselves.

  Third, others

  The outpatient and emergency expenses of novel coronavirus infection treatment for insured patients in other medical institutions shall be implemented in accordance with the medical insurance policies for other Class B infectious diseases.

通过admin

Store 26 in RT Mart is open normally, and the first store has been closed! How does the 100 billion-level "supermarket brother" turn over against the wind?

Recently, the news that RT Mart has closed stores in Jiangsu, Sichuan and other places has attracted attention. According to incomplete statistics, 13 stores have been closed in RT Mart since 2023. Among them, RT Mart Real Estate Plaza Store in Minhang District also closed in November last year.

Although a small number of closed stores belong to the normal business adjustment of enterprises, the situation that once "a brother of supermarkets" has now been transformed into a prostitute is also a silhouette of the loneliness of hypermarkets. The tide of Internet capital has receded, and traditional hypermarkets are still struggling to "save themselves for the second time".

26 stores in Shanghai are operating normally.

At 10 o’clock in the morning, the reporter came to RT Mart Daduhe Store in Putuo District. In the morning of working days, the popularity of Shangchao, where the supermarket is located, was generally not high, and the flow of people in RT Mart, which is located in the lower-level square, was relatively dull.

RT Mart Daduhe branch

Just entering the door, the reporter heard the salesperson at the door selling the stored-value card of "buy more and send more". Many middle-aged and elderly people chose dishes in the fresh fruit and vegetable area, and the weighing area was also lively. In contrast, there are almost no customers in snacks, grain and oil, department stores and other areas, and only a small number of shop assistants pick goods for online orders. When asked whether the closure of foreign stores affected the Shanghai store, the clerk expressed surprise: "This store is newly opened, and it is impossible to close it so soon."

The reporter learned that RT Mart Daduhe Store belongs to RT Mart Super format and belongs to a medium-sized community store. It just opened on December 28th last year, and it is the first supermarket in Putuo and the second supermarket in Shanghai.

The store covers an area of about 1,500 square meters, and its business categories mainly cover 5,300 SKUs (the smallest inventory unit) such as vegetables and fruits, grain and oil seasoning, drinks, etc. It belongs to the "mini version" of RT Mart. Compared with large supermarkets, the types of goods are greatly reduced, but they are much richer than those in community supermarkets such as Box Horse and Qingmei. In addition, the store’s online home service has been launched, and citizens place orders through channels such as RT Mart Youxian and Hungry, covering residential areas within 5 kilometers.

In response to the recent news of intensive store closures in RT Mart, RT Mart said that this is a normal business strategy adjustment in various regions, and both store closures and store opening are normal business actions. The closure of many stores in Jiangsu and Sichuan, on the one hand, is due to the property, on the other hand, it is the adjustment of local operation strategy, such as the transformation and upgrading to M member stores.

"RT Mart’s 26 stores in Shanghai are operating normally." Relevant persons in RT Mart told reporters that the closure of stores in other places did not affect Shanghai. However, the reporter learned that the RT Mart Real Estate Plaza store on Dongchuan Road closed in November last year due to the expiration of the lease.

It is understood that RT Mart opened its first large supermarket in Shanghai in 1998. At present, there are 26 stores in Shanghai, including 24 in RT Mart and 2 in RT Mart.

Embrace internet capital

RT Mart, under the leadership of founder Huang Mingduan, once created a "legend" of not closing stores for 19 years. The number of stores expanded from 1 to 500+, and the sales once exceeded 100 billion yuan, which was called "the first brother of supermarkets".

RT Mart official website shows that by 2021, RT Mart has successfully opened nearly 500 comprehensive large-scale supermarkets in Chinese mainland, covering five major regions of East China, North China, Northeast China, Central China and South China, serving more than 230 cities in 29 provinces (autonomous regions and municipalities), with more than 100,000 employees and more than 100,000 shopping guides, and serving more than 5 million customers every day.

However, with the end of the era of supermarkets, RT Mart’s "highlight moment" has gradually faded. Although RT Mart explored the e-commerce platform "flying cow net" early, its development was not as good as expected and it was at a loss for a long time. Especially in 2016, the revenue of RT Mart stores gradually declined. Almost at the same time, Ma Yun put forward the concept of "new retail" and advocated the integration of physical commerce and online platforms, which was Huang Mingduan’s dream that he wanted to do but failed to achieve.

Under the manipulation of Zhang Yong, in November 2017, Alibaba took a stake of HK$ 22.4 billion, directly and indirectly holding 36.16% of the shares of Gaoxin Retail (the parent company of RT Mart), and won the seat of the second shareholder. In October 2020, Alibaba invested HK$ 28 billion and continued to increase its 72% stake in Gaoxin Retail. Since then, Alibaba has become the controlling shareholder of RT Mart. Subsequently, Alibaba Vice President Lin Xiaohai served as CEO of RT Mart, reporting directly to Zhang Yong.

In a store in RT Mart, citizens are waiting in line to weigh.

Gaoxin Retail, Intime Department Store and Box Horse have become the three most critical pieces in Ali’s new retail matrix. At that time, Alibaba also announced that 484 stores of Gaoxin Retail in RT Mart and Auchan Supermarket had been fully online, and they were connected to Hungry, Taoxianda and Tmall Supermarket to share the inventory business. All stores provide one-hour delivery within 5 kilometers of the store, of which 180 stores support half-day delivery within 20 kilometers.

However, no matter how perfect the "marriage" is, it is hard to compete with the changes in the economic cycle.

After more than six years of integration into the Ali family, Gaoxin Retail has been in the channel of declining revenue. The net profit loss of returning to the mother in fiscal year 2022 expanded to 739 million yuan. In fiscal year 2023, the net profit of returning to the mother turned losses into profits, hovering near the breakeven line. Then, the semi-annual report of fiscal year 2024 showed that Gaoxin’s retail performance turned losses again. Not only that, the share price of Gaoxin Retail has plummeted in recent years, and its market value has shrunk by more than 70 billion yuan.

Bet on the "second growth curve"

RT Mart is by no means the only one in the throes of the curtain call in the era of hypermarkets. After the 2023 earnings season, domestic retail listed companies are even more "wailing".

Everyone in the "First Share of Private Supermarket" warned that the net assets at the end of 2023 are expected to be negative. According to relevant regulations, the company’s shares may be warned of delisting risks. Renrenle explained that due to the superposition of many unfavorable factors in the external market and internal operation, the income continued to decline and the operating performance was less than expected.

Backgammon, a leading retail enterprise in Hunan, also announced that it is estimated that the net profit attributable to shareholders of listed companies will be 1.32 billion yuan to 1.96 billion yuan in 2023, and there is still the risk that the company will be declared bankrupt by the court due to the failure of reorganization.

Carrefour’s business in China continued to be weak, which caused serious performance losses in Suning.cn. According to the disclosure, Carrefour China’s "slimming" brought about a sharp year-on-year decline in sales revenue, and increased the amount of compensation and other expenses incurred by the closure of the store. At the same time, it conducted impairment tests on long-term assets including goodwill. "Limited by the financial situation of Suning Tesco, it is difficult to quickly solve the liquidity problem of Carrefour China, and it needs to be adjusted and planned from a longer-term perspective."

Wal-Mart, an international giant, can’t escape the situation of "losing the hypermarket". Since 2016, Wal-Mart, which has more than 440 stores in China, has gradually reduced its stores in China, closing dozens of stores every year, and has closed 15 stores since 2023.

If you are poor, you will change, and if you change, you will pass. After the warehouse-style member stores such as Costco (Market Opening Guest) and Sam Member Store became a hit, the "Apprentice" Box Horse X Member Store also expanded rapidly, which made the traditional hypermarkets find a "lifeline" and RT Mart is also carrying out the second "self-help".

In the Daduhe Road store in RT Mart, citizens are shopping for goods.

It is understood that M member store is a high-end paid membership store under Gaoxin Retail, and it is also the second growth curve of Gaoxin Retail. There are about 3,000 pieces of goods in M member stores, more than 10% of which are self-owned brand products. At the same time, it also provides delivery service within 5 kilometers of the store.

Since the opening of the first store in Yangzhou in April last year, the total number of M member stores has reached 120,000. At present, three stores have been opened in Yangzhou, Changzhou and Nanjing, but they have not yet entered the first-tier cities such as Beishangguangshen and Shenzhen.

"Starting in March, RT Mart will open stores in Sichuan, Hubei, Jiangsu, Shandong, Zhejiang, Guangdong and Hainan provinces and cities, and reinstall and upgrade the old stores. This is another acceleration of Gaoxin Retail after opening 12 new stores in 10 cities across the country in January this year. " RT Mart replied in writing that it will open 21 new stores nationwide, complete the reconstruction of version 2.0 of 90 stores which have been rebuilt in RT Mart for more than 10 years, and some of them will be directly upgraded into M-member stores. In the future, Gaoxin Retail will continue to increase investment in member stores and accelerate the expansion of stores. It is estimated that five new stores will be opened in FY 2025, and 15 stores are expected to be opened within three years.

Lin Xiaohai has publicly stated for many times that "multi-format omni-channel" is the company’s long-term development strategy, and the accelerated opening of its M member stores and medium-sized supermarket Super does not mean the contraction of the hypermarket format in RT Mart.

"Now we are back!" In recent days, Alibaba’s foreign propaganda shows confidence, but time is running out for RT Mart.