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　　2021 is the first year for Jiangsu to implement the reform of the new college entrance examination. How to take the exam and how is the total cultural score made up? Jiangsu Education Examinations Institute announced the answers to key questions of Jiangsu 2021 college entrance examination.

　　1. When will the college entrance examination registration start in 2021?

　　A: The registration time for the 2021 college entrance examination is from November 11 to 14, 2020, and the deadline for information confirmation is November 17.

　　2. Who can register for the college entrance examination?

　　A: People who have registered in Jiangsu Province and meet the following conditions can apply for registration:

　　(1) Abide by the Constitution and laws of People’s Republic of China (PRC);

　　(2) graduated from a senior secondary education school or equivalent;

　　(3) Physical condition meets relevant requirements.

　　The children of migrant workers who are not registered in Jiangsu Province (hereinafter referred to as migrant children) who apply to take the college entrance examination in Jiangsu Province must meet the following conditions in addition to the above conditions:

　　(1) Obtaining a student status in an ordinary high school in Jiangsu Province and having a complete study experience in an ordinary high school;

　　(2) His guardian has a legally stable occupation and a legally stable residence (including lease) in Jiangsu Province.

　　Foreign nationals who have settled in Jiangsu Province and meet the registration requirements may apply for registration with the "Permanent Residence Identity Card of Foreigners of the People’s Republic of China" issued by the public security organ.

　　3. Who can’t register for the college entrance examination?

　　A: (1) College students with higher education qualifications, or students who have been admitted to colleges and universities and retain their admission qualifications;

　　(2) students who have not graduated from senior secondary education schools this year;

　　(3) fresh graduates who signed up by fraudulent means in the non-graduation year of senior secondary education and illegally participated in the entrance examination of ordinary colleges and universities (including the national unified examination, the provincial unified examination and the entrance examination organized by colleges and universities separately, hereinafter referred to as the entrance examination of colleges and universities);

　　(4) Persons who have been suspended from taking the college entrance examination due to violation of the national education examination regulations and are in the suspension period;

　　(5) Those who have been taken compulsory measures by the relevant departments or are serving sentences for violating the criminal law.

　　4. How do fresh graduates from senior secondary education schools register?

　　A: The fresh graduates of senior secondary education schools must follow the principle of "the college entrance examination and the ordinary high school level examination are registered in the same territory" and go through the registration procedures at the places designated by the enrollment examination institutions of the cities, counties (cities, districts).

　　5. How do previous students, social candidates and registered candidates from other provinces register?

　　A: Former students, social candidates and Jiangsu household registration candidates who borrow from other provinces should go through the registration procedures at the places designated by the admissions examination institutions in the cities and counties (cities, districts) where their household registration is located. All previous students, social candidates, Jiangsu household registration candidates who have borrowed from other provinces, and other non-ordinary high school graduates, etc., before the registration begins, all will be qualified by the staff of the admissions examination institutions before they can register online. Candidates who have been admitted to ordinary colleges and universities but have not reported or dropped out after reporting must hand in the admission notice of the relevant colleges and universities or provide proof of dropping out.

　　6. How to sign up for the accompanying children studying in our province?

　　Candidates with accompanying children must submit the Application Form for the College Entrance Examination of Migrant Workers and Employed Persons in Soviet Union in 2021 to the current middle school, which will be summarized and reported to the education administrative department of the school and the county (city, district) for enrollment, and the relevant registration procedures can be handled only after the examination. The following supporting materials shall be submitted at the time of registration:

　　(1) identification. The original and photocopy of the candidate’s second-generation ID card and household registration book.

　　(2) proof of stable residence. The originals and photocopies of the house title certificate, house sales contract and lease contract of the candidate himself or his guardian, or the temporary residence permit (residence permit) of the candidate and his guardian in Jiangsu Province.

　　(3) the guardian’s employment certificate. Original employment certificate issued by the guardian’s employment unit or community (village Committee) in Jiangsu Province.

　　7. What subjects can candidates apply for?

　　A: Candidates are divided into general categories, sports categories and art categories.

　　8. What are the exam subjects in 2021?

　　A: The main mode of the new round of college entrance examination reform in Jiangsu Province is "3+1+2".

　　Among them, "3" refers to the three subjects of Chinese, mathematics and foreign language in the unified college entrance examination; "1" refers to one subject selected by candidates in two optional examination subjects: physics and history; "2" refers to two subjects selected by candidates in four optional examination subjects: ideology and politics, geography, chemistry and biology.

　　Since 2021, the three unified examination subjects of Chinese, mathematics and foreign languages have adopted national unified proposition papers; According to the regulations of the Ministry of Education, the elective examination subjects are organized by the provinces themselves.

　　9. What are the subjects of cultural examination for sports and art candidates?

　　A: According to the needs of talent selection in colleges and universities, and referring to the consistent practices of other provinces, the cultural examination for physical education and art candidates in Jiangsu Province should not only take three unified examination subjects, such as Chinese, mathematics and foreign languages, but also choose one subject from two subjects, namely, physics and history, and then two subjects from four subjects, namely, ideology, politics, geography, chemistry and biology, according to their own interests and college enrollment requirements.

　　10. If you take the exam outside the number of languages in the unified college entrance examination, do you still need to take the qualification exam outside the number of languages?

　　A: Students who take the unified college entrance examination can use the unified college entrance examination of Chinese, mathematics and foreign languages to replace the qualification examination of the corresponding subjects.

　　11. How to arrange the examination time for the college entrance examination?

　　A: The examination time for three unified subjects, namely Chinese, Mathematics and Foreign Languages, and optional subjects is arranged in June each year. The foreign language subject examination consists of two parts: listening and written examination.

　　12. What is the total score of the college entrance examination culture?

　　A: The total score of the college entrance examination is set to 750. The total score of candidates consists of three subjects of Chinese, mathematics and foreign language in the national unified college entrance examination and three subjects of academic level selective examination selected by candidates.

　　Chinese, mathematics and foreign languages are three unified examination subjects, each with 150 points, of which foreign language subjects include 30 points for listening test. All subjects are included in the total score of candidates with original scores.

　　100 points for each of the 3 elective examination subjects. Among them, physics and history are included in the total score with the original score. The other four subjects (ideological and political, geography, chemistry, biology) are included in the total score with grades. For the elective examination subjects selected by students, the qualified test scores of the selected subjects must be qualified.

　　13. What are the combinations of elective examination subjects?

　　A: There are theoretically 12 combinations of elective examination subjects, and the specific combinations are as follows:

　　14. After successful online registration, can I modify the registration information?

　　A: Once the candidate’s registration information is printed and confirmed, no one can change it without authorization. If it is really necessary to modify the information due to special circumstances, the candidate himself shall apply to the registration point. After approval, the information shall be modified by the registration point, and it shall be re-printed and confirmed.

　　15. How to register for the provincial unified examination of art majors in 2021?

　　A: Candidates who apply for the provincial unified examination for art majors in colleges and universities in Jiangsu Province in 2021 must confirm and pay the information of the provincial unified examination for art majors from November 11 to 17. The deadline for information confirmation and payment of candidates is 17: 00 on November 17th.

　　After completing online payment, candidates must return to the system to check the payment status. When the payment status is "paid", the professional examination information confirmation form can be printed.

　　16. When will the provincial unified examination for music majors be held in 2021?

　　A: The written examination of the provincial unified examination for music majors is scheduled to be held on December 5, 2020, and the interview will be held from December 7. Among them, the written test center is located in Xianlin Campus of Nanjing Normal University, and the interview test center is located in Suiyuan Campus of Nanjing Normal University.

　　17. When will the provincial unified examination for fine arts majors be held in 2021?

　　A: The provincial unified examination for fine arts majors is scheduled for December 6, 2020. All 13 cities in Jiangsu Province have set up examination areas, and all candidates take the examination in the cities where the college entrance examination is registered.

　　18. What is the difference between a high-level art troupe and an art class?

　　A: High-level art troupes are enrolled in general classes. After being admitted to colleges and universities, they study in general classes. While studying this major, they take part in the school’s literary rehearsals and performances in their spare time. Art candidates apply for art, and according to the different majors, they will study art, music, dance or performance after admission.

　　In terms of examinations, the professional tests of high-level art troupes are organized by relevant institutions. Art professional examinations are divided into provincial unified examinations and college examinations. The provincial unified examination is organized by the Provincial Education Examinations Institute, including music, art and design, and radio and television editing and directing majors. The professional examinations organized by the enrollment institutions themselves are arranged by the enrollment institutions themselves.

　　19. What is the difference between high-level sports teams and sports?

　　A: The subjects of high-level sports teams are general, and they study in general majors after being admitted to colleges and universities. It is for ordinary colleges and universities to recruit candidates with sports expertise in order to enliven the campus sports atmosphere and meet the team-building needs of university sports meetings. Sports candidates apply for sports, and after being admitted to colleges and universities, they study sports majors such as physical education and social sports.

　　In terms of examination, according to the regulations of the Ministry of Education, the professional examination of high-level sports teams is organized by combining national unified examination, college entrance examination and college examination, and the examination implementation plan is formulated by the Science and Education Department of the State Sports General Administration. Sports candidates must take the provincial unified examination for sports majors.

　　20. Are the scores of compulsory subjects in the ordinary high school level test valid in the 2021 college entrance examination?

　　A: According to the "08 College Entrance Examination Scheme" of Jiangsu Province, the scores of compulsory subjects in the academic proficiency test of ordinary high schools are counted from the year of the college entrance examination and are valid for three years.

　　Candidates’ achievements in the compulsory subjects of the academic proficiency test from 2018 to 2020 are regarded as the academic proficiency qualification test results of the corresponding subjects, that is, if the candidates obtain "A, B, C" or "Qualified" in the compulsory subjects of the academic proficiency test in 2018 and beyond, they are regarded as qualified in the academic proficiency qualification test; If the score of the required course of learning and testing is "D" or "unqualified", it will be deemed that the subject is unqualified in the academic level qualification examination. (CCTV reporter Wu Rui)

Every reporter Sun Lei, every editor Pei Jianru

Out of the ICU, but not ashore yet. This is the evaluation of Xpeng Motors’s 2023 financial report by many people in the industry.

On March 19th, the latest data disclosed by Xpeng Motors showed that in 2023, the company’s total revenue was 30.68 billion yuan, a year-on-year increase of 14.2%. In terms of delivery volume, Xpeng Motors delivered 141,600 new cars in 2023, a year-on-year increase of 17%.

Although both revenue and delivery have increased, Xpeng Motors has not yet got rid of losses. In 2023, the net loss of Xpeng Motors was 10.38 billion yuan, which was 13.6% larger than that of 2022 (loss of 9.14 billion yuan). The gross profit margin of automobiles for the whole year was -1.6%.

The adjustment was effective, but it did not get rid of the annual loss.

Throughout the whole year of 2023, Xpeng Motors’s financial performance improved in the fourth quarter of that year, but it was under pressure due to the performance in the first three quarters.

The financial report shows that in the fourth quarter of 2023, the gross profit margin of automobiles in Xpeng Motors was 4.1%, while in the third quarter it was -6.1%, and the gross profit margin turned from negative to positive. In 2023, the gross profit rate of automobiles in Xpeng Motors was -1.6%, and in 2022 it was 9.4%.

It is reported that although Xpeng Motors has adopted discount and preferential policies for its models in order to meet the year-end sales, the change of sales structure and the change of average bicycle price have made Xpeng Motors improve its gross profit margin. In terms of sales structure, the proportion of Tucki G9 with higher unit price increased from 7% in the third quarter of 2023 to 26% in the fourth quarter.

In terms of bicycle cost, in the fourth quarter of 2023, the bicycle cost in Xpeng Motors was 191,000 yuan (excluding the impact of deduction), a decrease of 11,000 yuan from the previous month. The reason is that although the price of the new Tucki G9 is lower than that of the old one, the gross profit margin exceeds that of the old one under the technical cost reduction. At the same time, the price of lithium carbonate continued to decline, which naturally reduced the cost of vehicles in Xpeng Motors.

In fact, the above data changes are the result of Xpeng Motors’s continuous adjustment for more than a year. Since October, 2022, Xpeng Motors has made adjustments in its organizational structure. Especially after Wang Fengying joined Xpeng Motors as president, he tried to achieve the goal of cost reduction by streamlining SKUs, eliminating inefficient stores, merging sales theaters and optimizing purchasing strategies.

According to the financial report data, "saving money" has become one of the key directions of Xpeng Motors in 2023. This year, the number of employees in Xpeng Motors decreased from 15,829 in the same period last year to 13,550. At the same time, in terms of R&D, Xpeng Motors only increased its expenditure by 1.2% in 2023, and the number of R&D personnel decreased from 6,313 in the same period last year to 5,401.

Thanks to various measures, although the situation in Xpeng Motors has improved, it is still not completely "out of trouble". According to the financial report data, in the fourth quarter of 2023, Xpeng Motors’s net loss was 1.35 billion yuan, compared with 2.36 billion yuan in the same period last year and 3.89 billion yuan in the previous quarter. In 2023, Xpeng Motors’s net loss was 10.38 billion yuan, while in 2022, its net loss was 9.14 billion yuan, showing an expanding trend.

He Xiaopeng, Chairman and CEO of Xpeng Motors, said, "Xpeng Motors has integrated the intelligence, powertrain and vehicle platform into a large intelligent platform, so as to realize the maximum common sharing among all vehicles. Platform-based R&D and scale effect not only reduce the supply chain cost and manufacturing cost, but also greatly improve the efficiency of R&D iteration, thus enabling Tucki to accelerate the goal of reducing costs by 25%.

Want to challenge BYD with smart driving?

Looking forward to the first quarter of 2024, Xpeng Motors expects its car delivery to be between 21,000 and 22,500, an increase of about 15.2% to 23.4% year-on-year; The total revenue will be between 5.8 billion yuan and 6.2 billion yuan, increasing by about 43.8% to 53.7% year-on-year.

Data show that from January to February this year, Xpeng Motors delivered nearly 12,800 new cars. According to the delivery guideline for the first quarter, the delivery volume of Xpeng Motors in March may be less than 10,000 vehicles.

Investors are also cautious about Xpeng Motors’s future sales prospects and profit plans. "In addition to paying attention to the sales prospects in the first quarter of 2024, investors are also interested in the ‘ that Xpeng Motors plans to launch next month; Cheaper ’ The detailed plan of the model sub-brand is full of curiosity. " Qu Ke, an international analyst at CCB, said.

He Xiaopeng revealed in the earnings conference call: "During the 2024 Beijing Auto Show, Xpeng Motors will officially launch a brand-new brand for the level of 100,000 ~ 150,000 yuan. The first model of the brand new brand will be listed and delivered in the third quarter of this year. "

Gu Hongdi, honorary vice chairman and co-president of Xpeng Motors, said that the new brand will be sold first from the C-end, and then sold in the B-end and other channels a few months after being recognized by consumers. "The new brand model will be successful if it sells more than 10,000 vehicles per month. At present, our production capacity can support this goal." Gu Hongdi said.

It is worth noting that for the market segment of 100,000 ~ 150,000 yuan, new brands such as Wenjie, Ideality and Weilai have not been involved, while traditional brands such as BYD and Geely have not formed the advantage of intelligent driving. Therefore, the industry believes that He Xiaopeng has successfully found the breakthrough point in the cracks — — Play new brands with cost performance, and play traditional brands with smart driving.

National business daily reporter learned that the first model of Xpeng Motors’s new brand will cancel the lidar to reduce the cost of intelligent driving. At the same time, according to He Xiaopeng’s financial report conference call, Xpeng Motors has excellent cost control ability in intelligent driving, and it is expected to achieve the goal of reducing the cost of intelligent driving by 50% in 2024.

However, some people believe that consumers who buy cars in the price range of 150,000 yuan pay more attention to the cost performance, and the ability of intelligent driving has not yet entered the top five decisive factors affecting car purchase. In 2022, Xpeng Motors once put the intelligent driving function in the urban area on the P5 model in Tucki, but the purchase ratio of the actual intelligent driving version was not high.

The number of sales stores will increase to 600 in the third quarter.

In He Xiaopeng’s view, from 2024 to 2027, the elimination of smart electric vehicles officially began. "Xpeng Motors will enter the big product cycle of launching more than 10 new models in the next three years. Together with globalization and upgraded models, the total number of SOP models will reach 30." He Xiaopeng said in the earnings conference call.

When talking about the impact of the intensive release of new products on old products, He Xiaopeng said that the first thing to do after Wang Fengying joined Xpeng Motors at the beginning of last year was to solve this problem. "In order to avoid ‘ Infighting ’ Xpeng Motors will try to avoid the same type of products and there will be fewer car categories. " He Xiaopeng said.

Xpeng Motors’s product planning is regarded as similar to Wang Fengying’s product strategy of "having more children and fighting" when he worked for Great Wall Motor. It is reported that at the beginning of this year, Wang Fengying led a new round of organizational restructuring in Xpeng Motors, which involved product planning. According to industry analysts, Xpeng Motors may sell these models in a way similar to BYD’s sub-network, which is what Wang Fengying is good at.

From the channel point of view, Xpeng Motors is also moving closer to the field that Wang Fengying is good at. It is understood that Xpeng Motors launched the "Jupiter Plan" in July last year, releasing the franchise authorization of dealers and transferring some direct stores in Xpeng Motors to dealers for operation. By December 31st, 2023, there were 500 stores in Xpeng Motors, covering 181 cities.

He Xiaopeng said in the earnings conference call that Xpeng Motors completed a round of channel upgrade in 2023, eliminated more than 130 stores at the end, and introduced more than 160 dealers through "Jupiter Plan". Most of the new dealer stores have been open since the end of last year. It is estimated that the incubation period will take 3-4 months, which will make a significant contribution to the overall sales from April.

In addition, the reporter learned that since the second quarter of this year, Xpeng Motors has set up a channel inventory for about half a month to speed up terminal delivery. "Xpeng Motors will further expand the sales network coverage and accelerate the channel sinking. It is planned that by the third quarter of 2024, the number of sales stores will increase to 600, and it will continue to expand after the listing of new brands to accelerate sales growth. " He Xiaopeng said.

It is worth mentioning that since Wang Fengying joined Xpeng Motors, He Xiaopeng gave full support and authorization to her work, which made the effect of Xpeng Motors’s adjustment appear initially. However, such achievements are only the beginning. Whether the reform led by Wang Fengying can finally help Xpeng Motors get rid of losses and successfully "land" remains to be answered by time and the market.

Cover Image Source: Every photo by reporter Kong Zesi (data map)

Topic: "Perception of China" in Israel.

　　1. RoshHashana The Jewish New Year is the beginning of the year of the Jewish calendar (lunar calendar). It is one of the most important festivals for Jews. During the festival, the whole country has a two-day holiday. In the church, the horn was blown to talk to God, hoping to get God’s blessing. Friends meet to say "ShanaTova". According to tradition, people eat apples dipped in honey during the New Year, which indicates that the new year is sweet and beautiful.

　　2. YomKippur Yom Kippur is the tenth day after the Jewish New Year and is an important religious festival. Jews set this festival to confess to God and ask for forgiveness. Judaism stipulates that during Yom Kippur, you should fast for one day and pray and meditate in the church. When people meet in church, they wish each other a good evaluation from God. Yom Kippur ended with the melodious sound of horns in the evening.

　　3. Sukkot (Sukkot) This festival is to commemorate the life of living in a hut during the 40-year exile in Sinai after the Jewish ancestor Moses led the Jews out of Egypt. Therefore, the festival is in the harvest season, so it is also called the harvest festival. It is the main feature of every household to build a straw shed during the festival. The festival is celebrated for eight days. During this period, the IDF usually holds tank exhibitions in Tel Aviv’s municipal square.

Israel’s "Tent Festival"

　　4. SimhatTorah It usually takes a year for Jews to read Jewish classics. The Simhattorah is designed to celebrate the completion of reading, and the religious atmosphere is strong. This festival is a happy festival, so people (mainly Christians) should sing, dance and eat sweets. In the celebration ceremony, an essential item is to take down the scroll and walk seven times in your hand.

　　5. Hanukah Festival is to commemorate the success of Macabies’s uprising against the Greek invaders and the freedom of Jews. Legend has it that during the Jewish temple period, the seven olive oil lamps in the temple kept on burning, but they were eventually broken due to the destruction of the Greek invaders. After the victory of Macabies Uprising, I hope to rekindle the oil lamp. People looked around and found only enough olive oil for one day, but this olive oil was miraculously ordered for eight days until the new olive matured and new oil was added. Since then, Jews have set up festivals to commemorate this day when God helped them. This festival lasts for eight days, with two days off at the beginning and the end. The main celebration ceremony is to light a candle every day. Candlesticks with nine candlesticks are specially designed for this festival. Among them, the higher one in the middle is designed to ignite the other eight. At the beginning of the festival, people eat a special potato cake and then exchange gifts.

　　6. Purim means drawing lots. It is said that a wicked official hated a Jew who had offended him and set a date for killing all Jews by drawing lots. A Jewish woman who became a queen executed the wicked official and saved the Jews by playing around. During festivals, theaters usually put on plays about this story. People (mainly children) also wear masks about the characters in the story to attend the party, so some people call it the masquerade festival. At the party, people usually eat a special triangle cookie, which symbolizes the ear or hat of a bad official.

　　7. The Passover (Pessah) originated from the Bible Exodus. When Moses led the Jews out of Egypt to the Red Sea, he raised his staff to separate the Red Sea, and the Jews walked out of the Red Sea smoothly, while the chasing Egyptian army was submerged in the sea. The festival is celebrated for eight days, with two days off at the beginning and the end. Before the festival, people should remove all fermented pasta from their homes. During the festival, it is forbidden to sell and eat fermented food, and only a special unleavened pancake called Matsa can be eaten to commemorate the day when Jews could not eat fermented cakes when they left Egypt because of time constraints.

The traditional family feast of Jews during Passover.

　　8. Holocaust Remembrance Day (also known as Holocaust Remembrance Day) In order to commemorate the six million Jews killed by the Nazis between 1933 and 1945, the Knesset passed a decree in 1951, establishing the 27th of the Jewish calendar (April in Gregorian calendar) as Holocaust Remembrance Day. During the festival, orthodox Jews all over the world will fast for one day. Every family lights candles and reads the Jewish scripture Kadish. In Israel, an assembly or procession attended by the President, the Prime Minister and other important figures will be held to mourn the victims and celebrate the survival of the Jewish nation. At 10 o’clock in the morning, the national whistle sounded for two minutes, and the people stopped all work and stood in silence for the victims.

　　9. IDFMemorialDay This festival is set on the day before Independence Day to commemorate the soldiers of the National Defence Force who have given their lives to protect national security since the War of Liberation. At 8 o’clock the night before the festival, the national whistle sounded for one minute, and the people stood in silence. The National Defence Force also held an official commemorative ceremony at 8: 00 on the same day, attended by the President. At eleven o’clock the next morning, whistle again for two minutes.

　　10. IndependentDay was established to commemorate Israel’s independence in 1948. At eight o’clock the night before the festival, the Knesset held a formal celebration ceremony in Mount Herzl, Jerusalem, with the participation of parliamentarians and cabinet members. The ceremony included lighting 12 torches and firing salutes. The main activities on the day of the festival include a parade of the National Defence Forces, an air show, a reception hosted by the President for diplomatic missions and outstanding soldiers, an international Bible contest and an Israel Prize awarding ceremony. In addition, municipal governments also hold entertainment parties and set off fireworks.

Independence Day

　　11. Lagba-Omer means the 33rd day after the first day of Passover. According to legend, the Jewish rabbi Akiva organized Jews to recapture Jerusalem from the Romans on this day and lit a bonfire to inform the surrounding villages. Since then, Jews have commemorated the story of Achiwarabi and his recapture of Jerusalem with bonfires.

　　12. Jerusalem Day is a festival to commemorate Israel’s unification of Jerusalem in 1967. During festivals, there are usually grand celebrations in Jerusalem. The main celebration ceremony was held in front of the Western Wall at sunset the day before. Before the ceremony began, eighteen candles were lit to commemorate the soldiers who died in the battle to recapture Yecheng, followed by a thanksgiving ceremony. On the day of the festival, mass parades and other celebrations are held.

　　13. The forty-ninth day after the first day of Pentecost Passover is the day to commemorate Moses’ acquisition of the Ten Commandments. Therefore, the festival is catching up with the harvest of wheat and fruit, so it is also called the harvest festival. This is a happy festival, people should decorate their homes with flowers, and have a rich holiday meal with milk and cheese the night before the festival. Read the Ten Commandments on the festival day. At present, this festival has basically evolved into a children’s festival.

　　14. Tesha b ‘av means the ninth day of the Jewish calendar. According to legend, the Jewish temple was destroyed twice on this day. Jews commemorated this sad day with fasting.

Editor: Wang Yilin

　　Core reading

　　A few days ago, the Ministry of Science and Technology and other six departments issued a document, focusing on creating a number of major scenarios and expanding the application of artificial intelligence. High-level scientific research activities are one of them. Nowadays, China’s artificial intelligence technology is developing rapidly, and it has advantages in data acquisition, experimental prediction and result analysis. Life science, mathematics, chemistry, space science and other disciplines have embraced artificial intelligence. Rich application scenarios also feed back the development of technology and promote the upgrading of industrial wisdom.

　　From daily life to scientific research, today, China’s artificial intelligence technology is developing rapidly, and data and computing resources are increasingly abundant. Application demand is an important driving force for technological progress, and new technologies are often constantly improved and matured in "use". In order to promote the landing of artificial intelligence, a few days ago, the Ministry of Science and Technology and other six departments jointly issued the "Guiding Opinions on Accelerating Scene Innovation and Promoting High-quality Economic Development with High-level Application of Artificial Intelligence", focusing on creating several major scenes and expanding the application of artificial intelligence. High-level scientific research activities are one of them.

　　As a means of empowerment, how can artificial intelligence bring new research methods, and how can economic development inject "wisdom kinetic energy"?

　　Close integration helps scientific research to be more efficient and accurate.

　　Among many disciplines, life science research and artificial intelligence are closely integrated, and one of the hot directions is to predict protein structure.

　　Protein has a three-dimensional structure, and its primary structure (sequence) is composed of several amino acids in series. The three-dimensional structure determines the function of protein in cells, and many diseases are caused by the important protein structural abnormality in the body. Therefore, only by drawing a "three-dimensional map" of important protein in human body can we find the target of drugs acting on human body, thus developing accurate and effective new drugs.

　　Traditionally, scientists have observed the three-dimensional structure of protein by means of cryoelectron microscopy, X-ray and nuclear magnetic resonance, but this process is time-consuming, laborious and expensive. "Taking the cryomicroscope as an example, it costs tens of millions of yuan to arrange an observation platform, and it will take a long time for researchers to draw the protein structure." He Jingzhou, head of Baidu’s propeller bio-computing platform, said.

　　Due to the high difficulty, long experimental period and high cost, the number of three-dimensional structures of protein observed by traditional methods is very limited. In contrast, amino acid sequencing is much easier. Why can’t we predict the structure of protein based on the amino acid sequence? As early as 1972, American biochemist Christian anfinsen put forward this idea in his Nobel Prize acceptance speech.

　　It is precisely artificial intelligence that accurately predicts the three-dimensional structure of proteins from their primary structure. However, human beings have made slow progress in trying to analyze protein Group. It is explained that, on the one hand, because the existing biological data is small in quantity and low in quality, deep learning lacks enough samples; On the other hand, because the artificial intelligence algorithm is mature, it also needs a process.

　　In recent years, with the sharp increase of biological data and the optimization of artificial intelligence technology, scientists have established more accurate prediction models. In December 2020, in a competition, the artificial intelligence program "Alpha Folding" shined brilliantly, and its predicted results were similar to most experimental data. This proves that artificial intelligence has been quite accurate in predicting the structure of protein.

　　Nowadays, with the help of artificial intelligence, the work that may have taken several years can now be completed in a few minutes, and some protein structures that cannot be observed by traditional methods can also be analyzed.

　　It is understood that using artificial intelligence, researchers have predicted the structure of more than 200 million protein species of about 1 million species, covering almost every protein that has been recorded by the scientific community. This will have a great impact on the field of structural biology, which may lead to a paradigm change in life science research and enhance human understanding of life.

　　It has broad prospects and plays a role in many fields such as life science.

　　Artificial intelligence has entered the field of vision of life science research, and the demand of biomedical industry is an important driving force. According to reports, in the biopharmaceutical industry, the types of drugs that can be developed for every $1 billion invested have been declining. The research and development of new drugs is becoming more and more difficult, and the cycle is getting longer and longer. There is an urgent need for new methods to break through, and artificial intelligence has high hopes.

　　Not only does it accelerate the research and development of new drugs, but artificial intelligence is playing an important role in more and more fields of life sciences.

　　At the beginning of this year, a protein prediction model run by Chengdu Center of National Supercomputing helped the team of Wheat Research Institute of Agricultural College of Sichuan Agricultural University successfully analyze the molecular mechanism of PGS1 regulating seed development and affecting yield, and provided theoretical basis for cultivating high-yield and high-quality wheat materials. Researchers say that without artificial intelligence, it is difficult to make this breakthrough efficiently.

　　Researchers also try to introduce artificial intelligence technology into vaccine design. For example, compared with protein vaccine and DNA vaccine, mRNA vaccine has the advantages of fast mass production and good anti-infectivity, but its stability and immunogenicity are relatively poor. To make up for these shortcomings, researchers have been hoping to optimize the sequence design of mRNA vaccine to make it more stable and more immunogenic. With higher efficiency and lower cost, the intervention of artificial intelligence is expected to provide new ideas for vaccine research and development.

　　Precision therapy is also a stage for the application of artificial intelligence. Through the method of machine learning, in theory, artificial intelligence can decode the human immune system and explore the complex immune laws of some diseases more accurately, thus helping people understand diseases and develop therapeutic drugs and methods more efficiently and pertinently.

　　With the increase of human data and knowledge accumulated in new drug research and development brought by genomics research, and the continuous iteration of machine learning algorithms, industry experts believe that artificial intelligence has broad prospects in the field of life sciences. Some researchers even imagine to build a unified knowledge map by relying on a powerful biological computing engine and using a large amount of biological data to promote the understanding of life and health.

　　Rich scenes, pushing the application to a higher level.

　　Walking into life science research, artificial intelligence brings new methods, and it is also expected to open a new era of biomedical industry.

　　Experts in the industry said that seizing the new opportunities of intelligent drug design and strengthening the layout of artificial intelligence and biomedicine will help us to take the lead in the new track of new drug research and development.

　　Although artificial intelligence+biomedicine has developed rapidly, it has just started on the whole. He Jingzhou believes that the biomedical industry has a history of hundreds of years, with mature and perfect research processes, industrial chains and division of labor. The improvement of artificial intelligence is only some of them. "Biomedical is related to life and health, and the development of the industry should be steadily advanced, maintaining rationality and awe." Up to now, there is no new drug discovered entirely by artificial intelligence in the world. Some products developed by artificial intelligence are still a long way from the real market.

　　Seeing the advantages of artificial intelligence technology in data acquisition, experimental prediction and result analysis, mathematics, chemistry, materials science and space science have also embraced artificial intelligence.

　　The performance of lithium batteries varies with different material compositions. In response to the demand for lithium batteries in a variety of scenarios, researchers hope to design a suitable lithium battery system by optimizing the material combination.

　　"In the past, the design of material systems mainly relied on manual experiments, which was very inefficient." Zhang Qiang, a professor at the Department of Chemical Engineering in Tsinghua University, said that at present, he is leading the team to predict molecular properties with artificial intelligence, so as to find energy materials more efficiently and accurately and design more valuable and safer battery systems.

　　According to estimates, the scale of China’s artificial intelligence core industry exceeds 400 billion yuan, and the number of enterprises exceeds 3,000. Thanks to the strong demand brought by massive data processing and the experimental soil provided by rich application scenarios, China is at the forefront of the world in the fields of computer vision and speech recognition.

　　Experts in the industry suggest that it is necessary to give full play to the advantages of rich application scenarios in China to promote the application of artificial intelligence to a higher level. Creating a major scene around high-level scientific research activities will promote the application of artificial intelligence in China and inject "wisdom and kinetic energy" into high-quality economic development.